In vivo tritium contamination effects on water exchange across the erythrocyte membranes: a nuclear magnetic resonance study

The inhibition of water diffusion across the rat erythrocyte membrane was studied by NMR using two basically different types of inhibitory agents: PCMB and in vivo irradiation. The contribution of lipid and protein to water permeability revealed the inhibitory effect of each pathway. Internal contamination with tritium (25-115 mGy) reduces water permeability due to protein modifications; for doses higher than 100 mGy the lipid mediated mechanism seems also to be impaired. The same procedure enables one to assess the extent to which the higher water permeability of rat, compared to human, erythrocyte is due to one of the two pathways.

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NMR study of the selective inhibition of water permeability of rat erythrocyte membrane

Petcu

Lupu

Grosescu

1995

Bioscience Reports

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Kinetics of electroinduced pores as a probe of membrane modification produced by ionizing radiation

Petcu

Fologea

Radu

1997

Bioelectrochemistry and Bioenergetics

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In vivo tritium contamination effects on water exchange across the erythrocyte membranes: a nuclear magnetic resonance study

Cited by 2 publications

References 24 publications

NMR study of the selective inhibition of water permeability of rat erythrocyte membrane

NMR study of the selective inhibition of water permeability of rat erythrocyte membrane

Kinetics of electroinduced pores as a probe of membrane modification produced by ionizing radiation

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