In vivo UHMWPE biodegradation of retrieved prosthesis

Costa, Luigi; Luda, M. P.; Trossarelli, L.; Prever, Elena Maria Brach Del; Crova, Maurizio; Gallinaro, Paolo

doi:10.1016/s0142-9612(98)00013-1

Cited by 142 publications

(97 citation statements)

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“…These residual free radicals can migrate to the crystalline/amorphous interface and cause oxidation and reduction of UHMWPE elongation at break, tensile strength, fracture toughness and fatigue crack propagation resistance [33][34][35][36][37][38]. Therefore, to improve the oxidation resistance and the mechanical and fatigue strengths of cross-linked UHMWPE, antioxidant vitamin E is used to stabilise the radiation-induced free radicals [39][40][41][42].…”

Section: Vitamin-e-stabilised Uhmwpementioning

confidence: 99%

Wear Performance of UHMWPE and Reinforced UHMWPE Composites in Arthroplasty Applications: A Review

2015

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Abstract:As the gold standard material for artificial joints, ultra-high-molecular-weight polyethylene (UHMWPE) generates wear debris when the material is used in arthroplasty applications. Due to the adverse reactions of UHMWPE wear debris with surrounding tissues, the life time of UHMWPE joints is often limited to 15-20 years. To improve the wear resistance and performance of the material, various attempts have been made in the past decades. This paper reviews existing improvements made to enhance its mechanical properties and wear resistance. They include using gamma irradiation to promote the cross-linked structure and to improve the wear resistance, blending vitamin E to protect the UHMWPE, filler incorporation to improve the mechanical and wear performance, and surface texturing to improve the lubrication condition and to reduce wear. Limitations of existing work and future studies are also identified.

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Section: Vitamin-e-stabilised Uhmwpementioning

confidence: 99%

Wear Performance of UHMWPE and Reinforced UHMWPE Composites in Arthroplasty Applications: A Review

2015

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“…The material was well on its way to oxidation, with a shelf life of over 5 years, and most manufacturers now include a last implantation date on their UHMWPE components to reduce the risk of oxidation during storage. Major advances in the field were prompted by the knowledge of the oxidation map in depth at the polyethylene components (Costa et al 1998a) by Fourier-transformed infrared spectroscopy (FTIR) and electron spin resonance (ESR). Furthermore, an oxidation index (OI) was established (ASTM-F2102) by comparing the fingerprint of chemical species related to oxidation (carbonyl peak) and a reference species (methyl/methylene peak).…”

Section: Uhmwpe Oxidationmentioning

confidence: 99%

Update on UHMWPE research From the bench to the bedside

et al. 2008

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“…Oxidation and subsequent embrittlement of UHMWPE decrease the abrasive wear resistance and increase the wear debris associated with the polymer [9,27,28,49]. Radiation crosslinking of UHMWPE reduces wear in vitro [48,50,51,53] and in vivo [29,47] but also induces free radicals, which can cause oxidation.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E-stabilized UHMWPE for Total Joint Implants: A Review

Bracco

Oral

2011

Clinical Orthopaedics &Amp; Related Research

256

162

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Background Osteolysis due to wear of UHMWPE limits the longevity of joint arthroplasty. Oxidative degradation of UHMWPE gamma-sterilized in air increases its wear while decreasing mechanical strength. Vitamin E stabilization of UHMWPE was proposed to improve oxidation resistance while maintaining wear resistance and fatigue strength. Questions/purposes We reviewed the preclinical research on the development and testing of vitamin E-stabilized UHMWPE with the following questions in mind: (1) What is the rationale behind protecting irradiated UHMWPE against oxidation by vitamin E? (2) What are the effects of vitamin E on the microstructure, tribologic, and mechanical properties of irradiated UHMWPE? (3) Is vitamin E expected to affect the periprosthetic tissue negatively? Methods We performed searches in PubMed, Scopus, and Science Citation Index to review the development of vitamin E-stabilized UHMWPEs and their feasibility as clinical implants.Results The rationale for using vitamin E in UHMWPE was twofold: improving oxidation resistance of irradiated UHMWPEs and fatigue strength of irradiated UHMWPEs with an alternative to postirradiation melting. Vitamin E-stabilized UHMWPE showed oxidation resistance superior to that of irradiated UHMWPEs with detectable residual free radicals. It showed equivalent wear and improved mechanical strength compared to irradiated and melted UHMWPE. The biocompatibility was confirmed by simulating elution, if any, of the antioxidant from implants.Conclusions Vitamin E-stabilized UHMWPE offers a joint arthroplasty technology with good mechanical, wear, and oxidation properties. Clinical Relevance Vitamin E-stabilized, irradiated UHMWPEs were recently introduced clinically. The rationale behind using vitamin E and in vitro tests comparing its performance to older materials are of great interest for improving longevity of joint arthroplasties.

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In vivo UHMWPE biodegradation of retrieved prosthesis

Cited by 142 publications

References 0 publications

Wear Performance of UHMWPE and Reinforced UHMWPE Composites in Arthroplasty Applications: A Review

Wear Performance of UHMWPE and Reinforced UHMWPE Composites in Arthroplasty Applications: A Review

Update on UHMWPE research From the bench to the bedside

Vitamin E-stabilized UHMWPE for Total Joint Implants: A Review

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