In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging

Vasa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability

“…Because the spatial resolution of current commercially available OCT, namely frequency-domain OCT (FD-OCT), is sharp enough to detect microvasculatures, recent studies have suggested that coronary VV and intraplaque neovessels could be detected as a microchannel in an FD-OCT image (7,8).…”

Viewpoint: Recent Advances in Intracoronary Imaging for Vasa Vasorum Visualisation

“…1 We were able to demonstrate for the first time that a second-generation OCT (Terumo) is capable of visualising the adventitial VV in porcine and human coronary arteries ex vivo and in vivo (Figure 3). 18,19 We also showed the accuracy of manual measurements for adventitial VV on cross-sectional OCT images. 19 In order to develop the measurement method, we defined adventitial area as 'area outside the external elastic lamina within a distance of the thickness of intima plus media -vessel area' and adventitial VV area as 'adventitial VV area / adventitial area'.…”

“…The formation of VV has been suggested to initiate the development of coronary atherosclerosis. 35 We recently demonstrated that 18 F-fluorodeoxyglucose (FDG) PET can accurately detect PCAT inflammation in pigs ex vivo and in vivo. 36 Further studies with multimodalities (e.g.…”

Accuracy of Optical Frequency Domain Imaging for Evaluation of Coronary Adventitial Vasa Vasorum Formation After Stent Implantation in Pigs and Humans – A Validation Study –

“…15 Although ex vivo micro-computed tomography 24 has been suggested for the volumetric measurement of coronary adventitial VV in pigs, current imaging techniques are still limited to precisely measure coronary adventitial VV area in humans. Enhanced formation of adventitial VV after coronary stent implantation in pigs 25 and rabbits 26 has been previously demonstrated.…”