In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope

Hosoe, Naoki; Kanai, Takanori; Bessho, Rieko; Takayama, Tetsuro; Inoue, Nagamu; Imaeda, Hiroyuki; Iwao, Yasushi; Kobayashi, Seiki; Mukai, Makio; Ogata, Haruhiko; Hibi, Toshifumi

doi:10.1016/j.gie.2010.04.031

Cited by 15 publications

(11 citation statements)

References 16 publications

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“…This device can facilitate the differentiation of neoplastic and non-neoplastic lesions, and it can also guide the observations of celiac disease, amebic colitis, serrated polyps, and rectal carcinoids [7][8][9][10][11][12][13][14] . Furthermore, a correlation between EC classification and paired histological sample findings in UC patients has been reported [15] .…”

Section: Introductionmentioning

confidence: 99%

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Maeda¹,

Ohtsuka²,

Kudo³

et al. 2015

WJG

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AIM:To assess the efficacy of endocytoscopic narrowband imaging (EC-NBI) for evaluating the severity of inflammation in ulcerative colitis (UC). METHODS:This retrospective study was conducted at a single tertiary care referral center. We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013. EC-NBI was performed, and the images were evaluated by assessing visibility, increased vascularization, and the increased calibers of capillaries and were classified as Obscure, Visible or Dilated. Obscure was indicative of inactive disease, while Visible and Dilated were indicative of acute inflammation. This study received Institutional Review Board approval. The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity. The conventional endoscopic images were classified according to the Mayo endoscopic score. A score of 0 or 1 indicated inactive disease, whereas a score of 2 indicated active disease. RESULTS:Fifty-two patients were enrolled. There was a strong correlation between the EC-NBI findings and the histological assessment (r = 0.871, P < 0.01).The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%, 100%, 87.1%, 100%, and 92.3%, respectively, while those for the Mayo endoscopic score were 100%, 40.7%, and accuracy (P < 0.001, P = 0.001 and P = 0.047, respectively). CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC.

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Section: Introductionmentioning

confidence: 99%

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Maeda¹,

Ohtsuka²,

Kudo³

et al. 2015

WJG

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“…Two devices are currently available that allow in vivo microscopic inspection of the microstructural mucosal features of the gastrointestinal tract: confocal laser endomicroscopy (CLE) (Pentax, Tokyo, Japan, and Mauna Kea Technologies, Paris, France) [1][2][3][4][5][6] and an endocytoscopy system (ECS) with an ultra-magnification light microscopy device (Olympus Medical Systems, Tokyo, Japan) [1,[7][8][9][10]. There are two types of each device, probe-based and integrated-scope types [6,11].…”

Section: Introductionmentioning

confidence: 99%

“…However, no such studies have been conducted for ECS. ECS can provide a real-time image, as with light microscopy, and facilitate rapid diagnosis [10]. The aims of the present study were: (1) to develop a new UC scoring system based on ECS and (2) to validate the pathological and clinical utility of this scoring system.…”

Section: Introductionmentioning

confidence: 99%

Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis

et al. 2011

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“…In addition, it was shown that endocytoscopy could visualize H. pylori and Staphylococcus aureus ex vivo. One recent study evaluated the potential of endocytoscopy for in vivo visualization of trophozoites in patients with amoebic colitis . In vivo diagnosis would be of interest, as routine diagnosis of amebic colitis usually requires multiple tests.…”

Section: Advanced Colonoscopic Imaging Using Endocytoscopymentioning

confidence: 99%

“…37 One recent study evaluated the potential of endocytoscopy for in vivo visualization of trophozoites in patients with amoebic colitis. 38 In vivo diagnosis would be of interest, as routine diagnosis of amebic colitis usually requires multiple tests. Five patients who were suspected to have amebic colitis were included.…”

Section: Infectious Colitismentioning

confidence: 99%

Advanced colonoscopic imaging using endocytoscopy

Neumann

Kudo

Kießlich

2014

Digestive Endoscopy

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Optical biopsy techniques were recently introduced to luminal gastrointestinal endoscopy. These include confocal laser endomicroscopy, spectroscopic imaging techniques and endocytoscopy. Optical biopsy techniques allow on demand in vivo histology during ongoing endoscopy, thereby potentially accelerating clinical diagnosis and specific therapy. In the present review, we focus on endocytoscopy as one of the rapidly emerging optical biopsy techniques. We provide technical details of currently available endocytoscopy systems and give tips on their use in clinical practice. We also summarize applications of endocytoscopy for colorectal pathologies.

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In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope

Cited by 15 publications

References 16 publications

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis

Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis

Advanced colonoscopic imaging using endocytoscopy

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