In young men sperm telomere length is related to sperm number and parental age

Ferlin, Alberto; Rampazzo, Enrica; Rocca, Maria Santa; Keppel, Sonia; Frigo, Anna Chiara; Rossi, Anita De

doi:10.1093/humrep/det392

Cited by 94 publications

(98 citation statements)

References 31 publications

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“…Moreover, STL is related to sperm count. However, the relationship between LTL and sperm count did not demonstrate a significant correlation [27] . Considering the role of telomeres in meiosis and maintenance of genome integrity, the telomere shortening might lead to impaired spermatogenesis, followed by germ cells death.…”

Section: Discussionmentioning

confidence: 84%

“…Our results showed that there was a promising association between telomere length and the occurrence of azoospermia even if the telomere size was evaluated in the blood leukocytes of azoospermic males. In a study by Ferlin et al [27] it has been found that LTL was significantly correlated with SLT. Moreover, STL is related to sperm count.…”

Section: Discussionmentioning

confidence: 93%

“…Although there are numerous reports about relationship between male infertility and STL [8,31,32] , the correlation between azoospermia and leukocyte telomere length (LTL) has not been examined yet. A previous study has shown that the LTL is significantly correlated with SLT [27] . In the present study, our aim was to elucidate the possible genetic association between the relative telomere length (RTL) of leukocytes and male infertility in Iranian males affected by azoospermia.…”

Section: Introductionmentioning

confidence: 89%

“…Sperm telomere length (SLT) has an association with sperm count and chromosome abnormality, and it is lower in oligozoospermic than normozoospermic semen. Furthermore, shorter telomeres have been observed in infertile than fertile males [27] . Currently, a survey has demonstrated that SLT is connected with the motility and vitality of sperm, as well as sperm DNA fragmentation [28] .…”

Section: Introductionmentioning

confidence: 99%

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An Association Study between Longitudinal Changes of Leukocyte Telomere and the Risk of Azoospermia in a Population of Iranian Infertile Men

Heidary

Pouresmaeili

Mirfakhraie

et al. 2018

IBJ

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Background: Telomeres are evolutionary, specialized terminal structures at the ends of eukaryotic chromosomes containing TTAGGG repeats in human. Several human diseases have been known to be associated with dramatic changes in telomere length. The aim of the present study was to assess the correlation between the relative leukocyte telomere length (LTL) and infertility in a group of Iranian azoospermic males. Methods: In this casecontrol pilot study, relative telomere length (RTL) of peripheral blood leukocytes from a total of 30 idiopathic nonobstructive azoospermic males and 30 healthy fertile males was evaluated using real-time PCR. RTL was calculated as T (telomere)/S (single copy gene) ratio and compared between infertile and fertile groups. Results: Patients with azoospermia showed significantly shorter RTL than fertile males (0.54 vs. 0.84, p < 0.05). The area under the receiver operating characteristic (ROC) curve was estimated to be 99.8%, suggesting LTL as a potential marker for the diagnosis of azoospermia. Conclusion: Our findings demonstrated a probable association between telomere shortening and azoospermia in a population of Iranian infertile men affected by idiopathic azoospermia.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An Association Study between Longitudinal Changes of Leukocyte Telomere and the Risk of Azoospermia in a Population of Iranian Infertile Men

Heidary

Pouresmaeili

Mirfakhraie

et al. 2018

IBJ

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show abstract

“…While most of the studies evaluated the relationship between paternal age and leucocytes telomere length, the positive correlation between paternal age and offspring sperm telomere length was for the first time reported in 2013 by a study evaluating a small sample (81 subjects) of young men (18-19 years old) [73]. However, in this study, the maternal age was also positively correlated to sperm telomere length, and the contribution of each parents' age was difficult to established due to the high correlation between parents age.…”

Section: Telomere Lengthmentioning

confidence: 99%

The Impact of Aging on Fertility: Similarities and Differences between Ovaries and Testes

Albu¹,

Albu²

2017

Testes and Ovaries - Functional and Clinical Differences and Similarities

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The increasing age seems to have a negative impact on reproductive functions not only in women but also in men. Therefore, our aim was to review the data available in the literature regarding the impact of advancing age on fertility and the mechanisms underlying this association in both genders. The available data suggest that the effects of age on ovarian function cause a decrease in fertility starting 13 years before menopause. Statistics show that 10% of women will have a decreased fertility starting with the age of 30. The impact of age on ovary is due to both decreased number and quality of the oocytes, resulting in a high rate of chromosomal aneuploidy in the embryo and mitochondria dysfunction. Assisted reproductive technologies aiming to identify competent embryo were created but for the moment the results are unsatisfactory. On the other hand, in men, the semen quality and testicular function were found to gradually decrease with age and most of the studies also describe a negative impact on fertility. The mechanisms underlying decreased fertility are mainly genetic and epigenetics changes. However, if the effects of age on male fertility in men can be overcome by assisted reproductive technologies is not clear yet as the results of the studies are inconsistent.

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Cross‐Generational Effects of Parental Age on Offspring Longevity: Are Telomeres an Important Underlying Mechanism?

Heidinger

Young

2020

BioEssays

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Parental age at offspring conception often influences offspring longevity, but the mechanisms underlying this link are poorly understood. One mechanism that may be important is telomeres, highly conserved, repetitive sections of non‐coding DNA that form protective caps at chromosome ends and are often positively associated with longevity. Here, the potential pathways by which the age of the parents at the time of conception may impact offspring telomeres are described first, including direct effects on parental gamete telomeres and indirect effects on offspring telomere loss during pre‐ or post‐natal development. Then a surge of recent studies demonstrating the effects of parental age on offspring telomeres in diverse taxa are reviewed. In doing so, important areas for future research and experimental approaches that will enhance the understanding of how and when these effects likely occur are highlighted. It is concluded by considering the potential evolutionary consequences of parental age on offspring telomeres.

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In young men sperm telomere length is related to sperm number and parental age

Abstract: This work was supported by the Italian Ministry of University and Research (grant no. 2009AMPA9C to C.F.) and Padova University (grant 2010 to A.D.R.). The authors have no competing interests to declare.

Cited by 94 publications

References 31 publications

An Association Study between Longitudinal Changes of Leukocyte Telomere and the Risk of Azoospermia in a Population of Iranian Infertile Men

An Association Study between Longitudinal Changes of Leukocyte Telomere and the Risk of Azoospermia in a Population of Iranian Infertile Men

The Impact of Aging on Fertility: Similarities and Differences between Ovaries and Testes

Cross‐Generational Effects of Parental Age on Offspring Longevity: Are Telomeres an Important Underlying Mechanism?

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