Inaccuracy of Fine Needle Aspiration Biopsy

Orbital Mass Lesions: US-guided Fine-Needle Aspiration Biopsy—Experience in 37 Patients

“…It is generally held that it is often difficult to separate patients with lymphoid hyperplasia in the pseudotumor group from those with low-grade malignant lymphomas; three of the fine-needle aspiration biopsies with negative results in our study were from chronic pseudotumors. In keeping with the previous reports (4,5,8,9,18), our results also show that negative fine-needle aspiration biopsy results mostly come from fibrous lesions with sparse or exceedingly cohesive cell population or inadequate samples from lymphoid lesions; of the eight patients with negative fine-needle aspiration biopsy results, three had chronic pseudotumors and one had fibrocollagenous tissue at histopathologic examination. In keeping with the previous reports (4,5,8,9,18), our results also show that negative fine-needle aspiration biopsy results mostly come from fibrous lesions with sparse or exceedingly cohesive cell population or inadequate samples from lymphoid lesions; of the eight patients with negative fine-needle aspiration biopsy results, three had chronic pseudotumors and one had fibrocollagenous tissue at histopathologic examination.…”

“…The role of fine-needle aspiration biopsy in the evaluation of patients suspected of having orbital pseudotumors remains controversial (3,5,8,18,19). It is generally held that it is often difficult to separate patients with lymphoid hyperplasia in the pseudotumor group from those with low-grade malignant lymphomas; three of the fine-needle aspiration biopsies with negative results in our study were from chronic pseudotumors.…”

DNA Cell Cycle Studies In Uveal Melanoma

“…While fine-needle biopsy has a number of problems, the most important being potential sampling errors, such studies could be important in at least four settings. [90][91][92] First, we have previously demonstrated that alterations in DNA content are more closely correlated with survival than either cell type or tumor size. 93 Fine-needle biopsy and assessment of DNA aneuploidy could be a useful technique to increase the accuracy ofpretreatment prognosis assessment of uveal melanoma patients who are not treated with enucleation.…”

Fine needle aspiration cytology of orbital and ocular adnexal lesions

“…[3] The reported diagnostic accuracy of this technique for orbital and adnexal lesions ranged from 47% to 100% and its diagnostic value has been increased with the help of various ancillary methods. [235678910] In a series by Nag et al,[11] the sensitivity and specificity of FNAC in the diagnosis of orbital lesions was 86.6% and 100%, respectively. Although no major surgical intervention should be planned only based on FNAC results, this technique can be beneficial for planning further medical or limited surgical management of the orbital and adnexal lesions.…”