Inactivation of 5-Fluorouracil by the Liver during Continuous Regional and Systemic Infusion in Pigs

Almersjö, O; Brandberg, A; Gustavsson, Bengt; Hafström, Larsolof; Seeman, T

doi:10.1159/000127895

Cited by 7 publications

References 2 publications

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Disposition of 5‐fluorouracil during chronic hepatic arterial infusion to patients with carcinoma in the liver and effect on circulating platelets

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Ruedy

Shaw³

et al. 1979

Biopharm & Drug Disp

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5-Fluorouracil was administered by continuous hepatic intra-arterial infusion to eight patients with the diagnosis of cancer of the gastrointestinal tract and hepatic metastases. Its elimination characteristics were investigated to see if they correlated with therapeutic effect or reduced clinical toxicity when the drug was given by this route. Urinary excretion of drug and metabolites was similar to findings after intravenous bolus doses. Disposition changes could not be correlated with therapeutic effect or clinical toxicity. A dose-related biphasic effect of 5-fluorouracil was found on circulating platelets. Doses greater than 6 mg kg-1 d-1 decreased the number of circulating platelets, while doses less than that resulted in an increase in circulating platelets. Further studies are required to determine the mechanism of the effect of 5-fluorouracil on platelets.

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Disposition of 5‐fluorouracil during chronic hepatic arterial infusion to patients with carcinoma in the liver and effect on circulating platelets

Sitar

Ruedy

Shaw³

et al. 1979

Biopharm & Drug Disp

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Nasolacrimal System Injuries

Rocca

Ahmad

Preechawi

et al. 2007

Atlas of Lacrimal Surgery

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Regional and systemic serum concentrations of 5-fluorouracil after portal and intravenous infusion: An experimental study in dogs

Gustavsson

Brandberg

Regårdh³

et al. 1979

Journal of Pharmacokinetics and Biopharmaceutics

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The serum and urinary concentrations of 5-FU after continuous portal and jugular infusion have been followed by means of a highly sensitive microbiological assay method. Our data indicate that more than 90% of 5-FU was eliminated in the liver after continuous portal infusion of 0.625 mg x kg-1 x hr-1, corresponding to a dose of 15 mg x kg-1 x 24 hr-1. Negligible amounts of intact 5-FU were excreted into the bile, and the urinary excretion was only a few percent of the amount infused. The arterial concentration was on average tenfold higher during the continuous jugular infusion than after the continuous portal infusion, indicating that the route of administration has a pronounced effect on the disposition of 5-FU. Twenty-three percent of the jugular dose reached the liver; 77% was degraded by extrahepatic metabolism. Of these, degradation in the prehepatic splanchnic area accounted for 15%.

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Inactivation of 5-Fluorouracil by the Liver during Continuous Regional and Systemic Infusion in Pigs

Cited by 7 publications

References 2 publications

Disposition of 5‐fluorouracil during chronic hepatic arterial infusion to patients with carcinoma in the liver and effect on circulating platelets

Disposition of 5‐fluorouracil during chronic hepatic arterial infusion to patients with carcinoma in the liver and effect on circulating platelets

Nasolacrimal System Injuries

Regional and systemic serum concentrations of 5-fluorouracil after portal and intravenous infusion: An experimental study in dogs

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