Inactivation of Hippocampus or Caudate Nucleus with Lidocaine Differentially Affects Expression of Place and Response Learning

Packard, Mark G.; McGaugh, James L.

doi:10.1006/nlme.1996.0007

Cited by 1,351 publications

(1,410 citation statements)

References 7 publications

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“…The second strategy has been shown to be hippocampal specific, while the first is striatal specific (Devan et al, 1996;Packard and McGaugh, 1996). We suggest that the PCP-treated male rats were impaired in their capacity to use efficiently spatial cues (allocentric strategy), and compensated this spatial learning deficit by using a striatal idiocentric strategy.…”

Section: Discussionmentioning

confidence: 83%

Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Andersen

Pouzet

2004

Neuropsychopharmacol

119

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It has been suggested that perinatal treatment with the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (PCP) induces transient neurodegeneration in the limbic and cortical structures of rats. Since dysfunction of these structures is associated with cognitive deficits in patients with schizophrenia, we studied the effects of subchronic treatment with PCP in perinatal rats with respect to spatial reference, reversal, and spatial working memories using the Morris water maze task in adulthood. In addition, we investigated the effect of D-serine, which has clinical relevance for the treatment of cognitive deficits in patients with schizophrenia. Our goal was to develop a neurodevelopmental model with predictive validity for the cognitive dysfunction described in patients with schizophrenia. Male and female Sprague-Dawley rats were treated with either saline or PCP (8.7 mg/kg s.c.) on days 7, 9, and 11, postnatal, and the long-term behavioral effects were investigated in adulthood. Male PCP-treated rats were slightly impaired during the spatial reference memory task, but strongly impaired during the reversal and spatial working memory tasks. Female rats were not significantly affected by this treatment. This cognitive deficit was reversed by chronic treatment with D-serine. We suggest that this model mimics some of the cognitive deficits of patients with schizophrenia and might be appropriate for the screening of putative antipsychotic agents for the treatment of these cognitive deficits.

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Section: Discussionmentioning

confidence: 83%

Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Andersen

Pouzet

2004

Neuropsychopharmacol

119

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“…A previous study suggested that the number of training days has an 432 effect on whether an animal uses a place or response strategy for navigation 433 (Packard & McGaugh 1996). This study found that rats were more likely to 434 choose a response over a place strategy when they had more training in the 435 experimental set-up.…”

Section: (Zebrafish) 344mentioning

confidence: 77%

Place versus response learning in fish: a comparison between species

2015

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26Place learning is thought to be an adaptive and flexible facet of navigation. 27Due to the flexibility of this learning, it is thought to be more complex than the 28 simpler strategies such as learning a particular route or navigating through the 29 use of cues. Place learning is crucial in a familiar environment as it allows an 30 individual to successfully navigate to the same endpoint, regardless of where 31 in the environment the journey begins. Much of the research to date focusing 32 on different strategies employed for navigation has used human subjects or 33 other mammals such as rodents. In this series of experiments, the spatial 34 memory of four different species of fish (goldfish, killifish, zebrafish and 35Siamese fighting fish) was analysed using a plus maze set-up. Results 36 suggest that three of the species showed a significant preference for the 37 adoption of a place strategy during this task whereas zebrafish showed no 38 significant preference. Furthermore, zebrafish took significantly longer to learn 39 the task than the other species. Finally, results suggest that zebrafish took the 40 least amount of time (seconds) to complete trials both during training and 41 probe. 42

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“…In memory, declarative strategies are learned quickly, allow extensive flexibility, and involve the hippocampus [33,104,120], while procedural strategies are learned slowly, are inflexible, and involve the basal ganglia [91,120,192]. In navigation, locale navigation is learned quickly, allows extensive flexibility, and involves the hippocampus [126,150,173], while taxon navigation is learned slowly, is inflexible, and involves the caudate nucleus (part of the basal ganglia) [105,160,173].…”

Section: Resultsmentioning

confidence: 99%

The hippocampal debate: are we asking the right questions?

Redish

2001

Behavioural Brain Research

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For years, the debate has been: 'Is the hippocampus the cognitive map?' or 'Is the hippocampus the core of memory?' These two hypotheses derived their original power from two key experiments-the cognitive map theory from the remarkable spatial correlates seen in recordings of hippocampal pyramidal cells and the memory theory from the profound amnesias seen in the patient H.M. Both of these key experiments have been reinterpreted over the years: hippocampal cells are correlated with much more than place and H.M. is missing much more than just his hippocampus. However, both theories are still debated today. The hippocampus clearly plays a role in both navigation and memory processing. The question that must be addressed is rather: 'What is the role played by the hippocampus in the navigation and memory systems?' By looking at the navigation system as a whole, one can identify the major role played by the hippocampus as correcting for accumulation errors that occur within idiothetic navigation systems. This is most clearly experimentally evident as reorientation when an animal is lost. Carrying this over to a more general process, this becomes a role of recalling a context, bridging a contextual gap, or, in other words, it becomes a form of recognition memory. I will review recent experimental data which seems to support this theory over the more general spatial or memory theories traditionally applied to hippocampus.

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Inactivation of Hippocampus or Caudate Nucleus with Lidocaine Differentially Affects Expression of Place and Response Learning

Cited by 1,351 publications

References 7 publications

Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Spatial Memory Deficits Induced by Perinatal Treatment of Rats with PCP and Reversal Effect of D-Serine

Place versus response learning in fish: a comparison between species

The hippocampal debate: are we asking the right questions?

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