Inactivation of Pulmonary Surfactant by Lysophosphatidylcholine

Abstract

The aim of the study is to examine the influence of the lysophosphatidylcholine (lysoPC) to surface properties of INFASURF, a replacement lung surfactant, using the methods of thin foam films and Wilhelmy method. By the latter it is shown the change of surface tension (γ, mN/m) during time of the pure INFASURF and their mixture with lysoPC. Foam films are an efficient and useful model for the study of many surface phenomena especially for investigating the surface properties of pulmonary surfactant. Formation and stability of common black foam films (CBF) of pure INFASURF and of mixtures with various concentrations of lysoPC indicate the influence of low concentrations of lysoPC for the stability of CBF from INFASURF. It is proved that the curve W/C (where W is probability and C -concentration) is shifted to the lower concentrations.