Inactivation of SARS-CoV-2 on surfaces and in solution with Virusend (TX-10), a novel disinfectant

Anderson, Enyia R; Hughes, Grant L; Patterson, Edward I

doi:10.1099/acmi.0.000228

Cited by 12 publications

(12 citation statements)

References 22 publications

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“…UVC efficacy ranges from 36.4% to 100%. 29 , 30 , 34 , 48 , 60 , 61 Efficacy variability is attributed to the mode of usage as reported by the studies. 30 , 45 …”

Section: Resultsmentioning

confidence: 79%

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Retracted: Evaluating the effects of air disinfectants in decontamination of COVID‐19 aerosols

Dehghani

SeyedAlinaghi

Afroughi

et al. 2023

Health Science Reports

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Introduction Airborne transmission is the most  crucial mode of COVID‐19 transmission. Therefore, disinfecting the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) aerosols float can have important implications in limiting COVID‐19 transmission. Herein, we aimed to review the studies that utilized various disinfectants to decontaminate and inactivate the SARS‐CoV‐2 aerosols. Methods This study was a review that studied related articles published between December 1, 2019 and August 23, 2022. We searched the online databases of PubMed, Scopus, Web of Science, Cochrane, on August 23, 2021. The studies were downloaded into the EndNote software, duplicates were removed, and then the studies were screened based on the inclusion/exclusion criteria. The screening process involved two steps; first, the studies were screened based on their title and abstract and then their full texts. The included studies were used for the qualitative analysis. Results From 664 retrieved records, only 31 met the inclusion criteria and were included in the final qualitative analysis. Various materials like Ozone, H 2 O 2 , alcohol, and TiO 2 and methods like heating and using Ultraviolet were described in these studies to disinfect places contaminated by COVID‐19. It appeared that the efficacy of these disinfectants varies considerably depending on the situation, time, and ultimately their mode of application. Conclusion Following reliable protocols in combination with the proper selection of disinfectant agents for each purpose would serve to achieve desired elimination of the SARS‐CoV‐2 transmission.

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“…UVC efficacy ranges from 36.4% to 100%. 29 , 30 , 34 , 48 , 60 , 61 Efficacy variability is attributed to the mode of usage as reported by the studies. 30 , 45 …”

Section: Resultsmentioning

confidence: 79%

“…As a new method, it could be explored further for wide‐scale applications. 60 Electrostatic disinfectors and elastomeric respirators have also been reported to have high disinfection and filtration efficiency, respectively. They both present highly efficient methods of terminating aerosol viral transmission.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Evaluating the effects of air disinfectants in decontamination of COVID‐19 aerosols

Dehghani

SeyedAlinaghi

Afroughi

et al. 2023

Health Science Reports

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“…All experiments were carried out in triplicates. SARS-CoV-2 titre was calculated using standard plaque assays as previously described [ 33 ]. Briefly, samples were serially diluted in DMEM containing 2 % FBS and incubated with Vero cells for 1 h. After incubation, an overlay with DMEM 2 % FBS, 0.1 % gentamycin and 0.4 % agarose was applied to the cells.…”

Section: Methodsmentioning

confidence: 99%

CPC-containing oral rinses inactivate SARS-CoV-2 variants and are active in the presence of human saliva

Anderson

Patterson

Richards

et al. 2022

Journal of Medical Microbiology

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Introduction. The importance of human saliva in aerosol-based transmission of SARS-CoV-2 is now widely recognized. However, little is known about the efficacy of virucidal mouthwash formulations against emergent SARS-CoV-2 variants of concern and in the presence of saliva. Hypothesis. Mouthwashes containing virucidal actives will have similar inactivation effects against multiple SARS-CoV-2 variants of concern and will retain efficacy in the presence of human saliva. Aim. To examine in vitro efficacy of mouthwash formulations to inactivate SARS-CoV-2 variants. Methodology. Inactivation of SARS-CoV-2 variants by mouthwash formulations in the presence or absence of human saliva was assayed using ASTM International Standard E1052-20 methodology. Results. Appropriately formulated mouthwashes containing 0.07 % cetylpyridinium chloride but not 0.2 % chlorhexidine completely inactivated SARS-CoV-2 (USA-WA1/2020, Alpha, Beta, Gamma, Delta) up to the limit of detection in suspension assays. Tests using USA-WA1/2020 indicates that efficacy is maintained in the presence of human saliva. Conclusions. Together these data suggest cetylpyridinium chloride-based mouthwashes are effective at inactivating SARS-CoV-2 variants. This indicates potential to reduce viral load in the oral cavity and mitigate transmission via salivary aerosols.

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“…A spray-based disinfectant was developed by the British Army in the early days of the pandemic to provide protection for its service people. The spray demonstrated efficacy against the COVID-19 virus at a level required by British and European standards for surface disinfectants used in the medical settings (Anderson et al, 2021 ), and proof of concept field trials conducted by the Army confirmed the spray technology delivered rapid, high-density coverage. The Army was keen to make this technology available in the healthcare setting to help protect patients and healthcare workers.…”

Section: Introductionmentioning

confidence: 92%

Rapid qualitative analysis in a mixed-methods evaluation of an infection prevention intervention in a UK hospital setting during the COVID-19 pandemic: A discussion of the CLEAN study methodology

Higham

Pini²,

Quyn³

et al. 2022

Front. Sociol.

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The COVID-19 pandemic created an urgent need for high-quality rapid research. One clinical challenge was how to minimise the risk of transmission in the hospital setting. The CLEAN study conducted a rapid evaluation of the potential utility of a spray-based disinfectant in a hospital setting. The study was undertaken between December 2020 and March 2021 and involved the implementation of the spray in 10 different clinical areas in one UK teaching hospital. A mixed-methods approach was adopted (including observations, surveys, and qualitative interviews) informed by the theories for understanding the implementation of new healthcare technologies. The evaluation found that while the spray had a number of perceived benefits when added to existing disinfection processes, other factors limited its potential utility. These findings informed a number of recommendations for future adoption within hospital settings. This paper describes and reflects on the rapid methodology that allowed us to undertake the study and deliver results in a short space of time. We experienced a number of pressures during set-up and fieldwork due to the challenging conditions caused by the pandemic, and the methodological approach had to evolve throughout the study because of the changing clinical context. The involvement of clinicians from the research setting as full members of the research team was key to the rapid delivery of the research. They provided an essential link to the implementation environment, and their experiential knowledge of the setting added an important perspective to the analysis. Balancing their involvement with their clinical roles was challenging, however, as was coordinating a large and diverse team of interviewers in such a short space of time. Overall, the study highlighted the value of rapid research to inform urgent healthcare decisions in a pandemic. Although our experience suggests that conducting such research requires some practical and methodological trade-offs, we found that there were also numerous benefits of using rapid methods and identified various opportunities to ensure their robustness.

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Inactivation of SARS-CoV-2 on surfaces and in solution with Virusend (TX-10), a novel disinfectant

Cited by 12 publications

References 22 publications

Retracted: Evaluating the effects of air disinfectants in decontamination of COVID‐19 aerosols

Retracted: Evaluating the effects of air disinfectants in decontamination of COVID‐19 aerosols

CPC-containing oral rinses inactivate SARS-CoV-2 variants and are active in the presence of human saliva

Rapid qualitative analysis in a mixed-methods evaluation of an infection prevention intervention in a UK hospital setting during the COVID-19 pandemic: A discussion of the CLEAN study methodology

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