2003
DOI: 10.1038/sj.leu.2403026
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Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma

Abstract: Chromosomal band 1p34-36 is a commonly rearranged locus in many types of cancers. We cloned the breakpoint region of a chromosomal translocation, t(1;14)(p34;q32), found in the human multiple myeloma (MM) cell line, ODA. This rearrangement occurred between the nearby switch region of the immunoglobulin heavy chain (IgH) gene (Sc3) at 14q32 and the first intron of the human retinoic acid-inducible E3 protein (E3)/lysosomeassociated protein, transmembrane-5 (LAPTm5) gene at the 1p34 locus. Consequently, the E3 g… Show more

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Cited by 30 publications
(19 citation statements)
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“…GCD-10, the LAPTm5 ortholog in rats, was found to be activated in response to neuronal apoptosis (Origasa et al 2001). Recently, inactivation of the LAPTm5 gene was observed in human multiple myeloma (Hayami et al 2003). Although this protein is structurally related to a family of lysosomal transporter proteins that regulate cellular multidrug resistance (Cabrita et al 1999), its function remained unknown.…”
Section: Discussionmentioning
confidence: 99%
“…GCD-10, the LAPTm5 ortholog in rats, was found to be activated in response to neuronal apoptosis (Origasa et al 2001). Recently, inactivation of the LAPTm5 gene was observed in human multiple myeloma (Hayami et al 2003). Although this protein is structurally related to a family of lysosomal transporter proteins that regulate cellular multidrug resistance (Cabrita et al 1999), its function remained unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Are there any human immunodeficiencies or autoimmune diseases that are associated with dysregulated LAPTM5 function? It is interesting to note that Laptm5 gene is inactivated by either chromosomal deletion or promoter methylation in four cases of human multiple myeloma (Hayami et al, 2003), raising the possibility that LAPTM5 may also have a tumor-suppressor function in humans.…”
Section: Pathway Is Not Limited By Other Proteins and Is Independentlmentioning
confidence: 99%
“…Of these, three -the duplicated LAPTM5 and HSH2D (ALX) and the hemizygously deleted CD28 -have been shown to be involved in hematopoiesis and/ or hematologic malignancies. 32,33 In conclusion, the present array CGH analysis revealed cryptic chromosome changes in nine of 10 AML/MDS cases with trisomy 8 as the sole cytogenetic abnormality. Excluding imbalances overlapping with previously described CNPs, novel -and possibly leukemia-associated -aberrations were found in four (40%) of the cases.…”
Section: Gli3mentioning
confidence: 99%