Inactivation of the human papillomavirus-16 e6 oncoprotein by organic disulfides

Disulfides – Effective radical generators for flame retardancy of polypropylene

“…were supplied by BASF, products 1, 2, 4, 6, 10, 12, 13 were purchased from Sigma Aldrich Corporation and compounds 5 [52], 7 [53], 8 [54], 9 [55] were prepared according to previously described procedures. For comparison a commercial alkoxyamine Flamestab®NOR116 (supplier BASF SE) was used.…”

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

“…This process is followed by ejection of the metal ion from the zinc finger that occurs as a result of the destabilized Zn(II) ion coordination sphere. A similar pharmacological approach has been taken to target the oncogenic human papilloma virus HPV-16 by disrupting the E6 oncoprotein containing two Cys-[X] 2 -Cys-[X] 29 -Cys-[X] 2 -Cys zinc fingers (23). In a large series of redox-active di-and polysulfides, including 4,4 0 -dithiodimorpholine-derivatives, potent anti-HPV compounds were identified that produced a release of zinc from E6 with induction of cytotoxicity selective for the HPV-infected cells.…”

“…The selectivity of electrophilic agents toward zinc fingers depends on multiple physicochemical parameters including redox potential, reactive proximity, and noncovalent ligandbinding affinity (23,52,361). For example, electrochemical analysis of the Sp1 zinc finger by cyclic voltammetry revealed a redox potential that thermodynamically favors preferential oxidative disruption of this particular thiol target by redox cycler prototype organochalcogens in oxidatively stressed cells with lowered glutathione content (128).…”

Antibacterial Role of SO42−, NO3−, C2O42− and CH3CO2− Anions onCu(II) and Zn(II) Complexes of a Thiadiazole‐derived PyrrolylSchiff Base

“…The charge transfer band at 28665-28850 cm was assigned 32 to 2Eg 2T2g transitions possibly in an octahedral environment (Fig 2). [10][11][12][13][14] (45-64 %); +++, [14][15][16][17][18] (64-82 %); ++++, [18][19][20][21][22] (82-100 %). Percent inhibition values are relative to inhibition zone (22 mm) of the most active compound with 100 % inhibition.…”

“…These compounds possess such interesting biological properties that may be conferred to them by their strong aromatic ring system .A s ligands, they also provide many potential 12 14 binding sites for complexation and have obtained a diversified biological activity by the result of such chelation. It has been suggested 6 that the interaction of the metal ion with potentially biologically active compounds lead to destroy or greatly help to diminish [7][8][9][10][11][12][13][14][15][16][17][18][19] the role of bacteria-/virus-/cancer-associated organisms and therefore, represent a significant route for designing and establishing novel metal-based antibacterial, antiviral and anticancer therapies2. In previous works we have explored the biological properties of thiadiazole-derived compounds and the effect of chelation on their bactericidal properties2.…”