Inactivation of the pseudorabies virus by dithiothreitol

Gainer, Joseph H.; Long, John C.; Hill, Paul R.; Capps, Worth I.

doi:10.1016/0042-6822(71)90116-4

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…Kinetics of inactivation by DTT. Gainer et al (6) showed that the rate of inactivation of pseudorabies virus by DTT was temperature dependent under mild alkaline conditions, being more rapid as the temperature was raised from 30 to 41 C.…”

Section: Resultsmentioning

confidence: 99%

“…At present, the strain differences in sensitivity to DTT are difficult to explain. In studies on another herpesvirus, the pseudorabies virus, Gainer et al (6) tried to explain the mechanism of inactivation by this drug. The main effect of DTT as determined by electron microscopy is disruption of the coat of the virion, probably due to cleavage of S-S linkages in cystine.…”

Section: Discussionmentioning

confidence: 99%

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Equine Abortion (Herpes) Virus: Strain Differences in Susceptibility to Inactivation by Dithiothreitol

Klingeborn¹,

Dinter²

1972

Applied Microbiology

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The infectivity of equine abortion (herpes) virus (EAV) was inactivated by treatment with reduced dithiothreitol (DTT). According to their susceptibility to DTT, the EAV strains could be divided into three groups. The vaccine strain RAC-H (419) proved to be more resistant to DTT than all of the other 14 strains tested. The hemagglutinin of EAV was also inactivated by DTT; no strain differences were observed in this respect.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%