Inactivation of viruses on surfaces by infrared techniques

Karaböce, Baki; Saban, Evren; Böyük, Ahsen Aydın; Durmus, Huseyin Okan; Hamid, Rauf; Baş, Ahmet

doi:10.1016/j.ijthermalsci.2022.107595

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…They have also been successfully inactivated by UV [5] , [26] and advanced treatment processes such as photocatalysis, ozonation, and chlorination [5] , [26] , [30] , [31] , [32] . The same is true for phi6, which has been shown to be susceptible to inactivation by advanced treatments such as UV irradiation (200 – 320 nm) [7] , [18] , [23] , IR radiation [22] and free chlorine [21] , [23] .…”

Section: Introductionmentioning

confidence: 81%

“…The bacteriophage phi6 is often used as a surrogate for enveloped viruses such as Ebola virus, influenza viruses, or CoVs [3] , [4] , [7] , [9] , because of its similar size (∼ 80-100 nm), and lipid envelope with spike proteins [17] , [18] , [19] . It has often been used as a surrogate for enveloped viruses to either learn about their fate in the environment under various conditions [3] , [4] , [9] , [20] , [21] or their susceptibility to inactivation by advanced treatment processes [7] , [18] , [21] , [22] , [23] or materials [19] , [24] . Due to their lipid bilayer, enveloped viruses are susceptible to inactivation by chemical agents [25] , [26] , [27] , [28] as well as harsher environmental conditions such as elevated temperatures [3] , [4] , [20] , [21] or high humidity [20] , [29] .…”

Section: Introductionmentioning

confidence: 99%

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Inactivation of the enveloped virus phi6 with hydrodynamic cavitation

Zupanc

Zevnik

Filipić

et al. 2023

Ultrasonics Sonochemistry

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Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Inactivation of the enveloped virus phi6 with hydrodynamic cavitation

Zupanc

Zevnik

Filipić

et al. 2023

Ultrasonics Sonochemistry

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“…In turn, phage P001 42 is sensitive to changes in pressure. Radiation—infrared and microwaves—leads to inactivation of phage Φ6 43 and T4, T7, λ, MS2 phages, respectively. Another physical method which causes a loss in titer in the case of MS2 and M13 is the use of columns of microplastic 44 .…”

Section: Discussionmentioning

confidence: 99%

Stability study in selected conditions and biofilm-reducing activity of phages active against drug-resistant Acinetobacter baumannii

Bagińska,

Grygiel,

Orwat

et al. 2024

Sci Rep

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Acinetobacter baumannii is currently a serious threat to human health, especially to people with immunodeficiency as well as patients with prolonged hospital stays and those undergoing invasive medical procedures. The ever-increasing percentage of strains characterized by multidrug resistance to widely used antibiotics and their ability to form biofilms make it difficult to fight infections with traditional antibiotic therapy. In view of the above, phage therapy seems to be extremely attractive. Therefore, phages with good storage stability are recommended for therapeutic purposes. In this work, we present the results of studies on the stability of 12 phages specific for A. baumannii under different conditions (including temperature, different pH values, commercially available disinfectants, essential oils, and surfactants) and in the urine of patients with urinary tract infections (UTIs). Based on our long-term stability studies, the most optimal storage method for the A. baumannii phage turned out to be − 70 °C. In contrast, 60 °C caused a significant decrease in phage activity after 1 h of incubation. The tested phages were the most stable at a pH from 7.0 to 9.0, with the most inactivating pH being strongly acidic. Interestingly, ethanol-based disinfectants caused a significant decrease in phage titers even after 30 s of incubation. Moreover, copper and silver nanoparticle solutions also caused a decrease in phage titers (which was statistically significant, except for the Acba_3 phage incubated in silver solution), but to a much lesser extent than disinfectants. However, bacteriophages incubated for 24 h in essential oils (cinnamon and eucalyptus) can be considered stable.

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“…Phi6 is a dsRNA lytic bacteriophage of the Cystoviridae virus family which infects Pseudomonas bacteria ( 40 , 41 ). It possesses similarities to that of coronaviruses, namely, it is of similar size, has spike proteins and is enveloped by a lipid membrane ( 40 , 41 , 42 ), and thus has been suggested and utilized as a surrogate for the study of SARS‐CoV‐2 in multiple publications ( 35 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ).…”

Section: Discussionmentioning

confidence: 99%

Viricidal Efficacy of a 405‐nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS‐CoV‐2

Sinclair

Ilieva

Morris

et al. 2023

Photochem & Photobiology

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The highly transmittable nature of SARS-CoV-2 has increased the necessity for novel strategies to safely decontaminate public areas. This study investigates the efficacy of a low irradiance 405-nm light environmental decontamination system for the inactivation of bacteriophage phi6 as a surrogate for SARS-CoV-2. Bacteriophage phi6 was exposed to increasing doses of low irradiance (~0.5 mW cm À2 ) 405nm light while suspended in SM buffer and artificial human saliva at low (~10 3-4 PFU mL À1 ) and high (~10 7-8 PFU mL À1 ) seeding densities, to determine system efficacy for SARS-CoV-2 inactivation and establish the influence of biologically relevant suspension media on viral susceptibility. Complete/near-complete (≥99.4%) inactivation was demonstrated in all cases, with significantly enhanced reductions observed in biologically relevant media (P < 0.05). Doses of 43.2 and 172.8 J cm À2 were required to achieve ~3 log 10 reductions at low density, and 97.2 and 259.2 J cm À2 achieved ~6 log 10 reductions at high density, in saliva and SM buffer, respectively: 2.6-4 times less dose was required when suspended in saliva compared to SM buffer. Comparative exposure to higher irradiance (~50 mW cm À2 ) 405-nm light indicated that, on a per unit dose basis, 0.5 mW cm À2 treatments were capable of achieving up to 5.8 greater log 10 reductions with up to 28-fold greater germicidal efficiency than that of 50 mW cm À2 treatments. These findings establish the efficacy of low irradiance 405-nm light systems for inactivation of a SARS-CoV-2 surrogate and demonstrate the significant enhancement in susceptibility when suspended in saliva, which is a major vector in COVID-19 transmission.

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Inactivation of viruses on surfaces by infrared techniques

Cited by 7 publications

References 39 publications

Inactivation of the enveloped virus phi6 with hydrodynamic cavitation

Inactivation of the enveloped virus phi6 with hydrodynamic cavitation

Stability study in selected conditions and biofilm-reducing activity of phages active against drug-resistant Acinetobacter baumannii

Viricidal Efficacy of a 405‐nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS‐CoV‐2

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