Inactive Renin in Rabbit Plasma: Effect of Haemorrhage

Richards, Hugh K.; Grace, S A; Noble, A. R.; Munday, K. A.

doi:10.1042/cs0560105

Cited by 18 publications

(17 citation statements)

References 11 publications

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“…1979;Richards et al 1979). Figure 2 shows similar data for haemorrhage-induced increases in plasma active renin in anaesthetized sheep.…”

Section: Discussionsupporting

confidence: 79%

Haemorrhage‐induced Secretion of Active and Inactive Renin in Conscious and Pentobarbitone‐anaesthetized Sheep

Mzail¹,

Noble²

1986

Clin Exp Pharma Physio

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The response of plasma levels of active and inactive renin to haemorrhage was investigated in sheep with indwelling artery and vein catheters. In conscious animals, loss of 10% of estimated blood volume over a 5 min period increased plasma active renin by a mean of 59%, a surprisingly small change. Plasma inactive renin also increased, but only by 86%. Maximum increases in both forms of renin occurred within 1 h of the haemorrhage. The effects of an equivalent blood loss were investigated in pentobarbitone-anaesthetized sheep maintained in an upright posture using padded slings. Anaesthesia per se had no effect on plasma active or inactive renin. In anaesthetized sheep, 3 h after haemorrhage, plasma active renin had increased by 403% and inactive renin by 299% above control values, but a plateau (maximum) response was not reached during this time. In both conscious and anaesthetized animals the haemorrhage-induced increases in active and inactive renin occurred in parallel. It appears that haemorrhage of this intensity is a comparatively mild stimulus to increase plasma renin concentration in conscious sheep but is much more effective in anaesthetized animals. This may be linked to anaesthetic-induced increases in prostaglandin synthesis within the kidney.

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“…1979;Richards et al 1979). Figure 2 shows similar data for haemorrhage-induced increases in plasma active renin in anaesthetized sheep.…”

Section: Discussionsupporting

confidence: 79%

Haemorrhage‐induced Secretion of Active and Inactive Renin in Conscious and Pentobarbitone‐anaesthetized Sheep

Mzail¹,

Noble²

1986

Clin Exp Pharma Physio

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“…1966; Hall & Hodge 1971;Feuerstein et al 1982;Coli et al 1981;Richards et al 1979). In rabbits APRC and IPRC rose with mild haemorrhage (Richards et a/.…”

Section: Discussionmentioning

confidence: 94%

Active and Inactive Renin in Critically Ill Patients

Thatcher

Butty

Whitworth

et al. 1985

Clin Exp Pharma Physio

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The relationship between active (A) and inactive (I) plasma renin concentrations (PRC) was examined in critically ill patients to test for intravascular renin activation in states of shock and tissue damage. Critically ill patients had significantly elevated APRC and lowered IPRC:APRC ratio compared with age and sex matched healthy subjects. IPRC in the critically ill was similar to the control group. During blood donation normal volunteers showed a twofold increase in APRC. The rise in APRC was proportionately greater than for IPRC, with a subsequent fall in IPRC:APRC ratio. In both critically ill patients and blood donors elevated APRC was associated with decreased IPRC:APRC ratio, consistent with either consumption of the inactive renin zymogen or preferential secretion of the active form. Individual critically ill patients displayed markedly depressed ratios but with only moderately elevated APRC, a pattern suggestive of intravascular renin activation. Consistent evidence for intravascular or extravascular activation of renin was not apparent.

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“…1 Cooper, 1978), rat (Morris & Johnston, 1976), rabbit (Richards, Grace, Noble & Munday, 1979). mouse (Poulsen, 1979) and hog (Bailie, Derkx & Schalekamp, 1979) plasma using acid or tryptic activation.…”

Section: Discussionmentioning

confidence: 98%

Cryoactivation Fails to Augment Plasma Renin Activity in the Cat

Golin

Morganti

Busnardo

et al. 1982

Clin Exp Pharmacol Physiol

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1. Active and cryoactivated renin (plasma renin) activity after incubation at -5 degrees C for 4 days, were measured in cat plasma sampled before and during the following procedures: suprarenal aortic stenosis, electrical stimulation of the pons and mild hypotensive haemorrhage. 2. Under all experimental conditions the values of plasma renin activity for both the activated and non-activated samples were similar. 3. The absence of a cryoactivatable aliquot of renin suggests that in cat plasma the inactive form of the enzyme either is actually absent or has a liability to the action of cold different than in other animal species.

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Inactive Renin in Rabbit Plasma: Effect of Haemorrhage

Cited by 18 publications

References 11 publications

Haemorrhage‐induced Secretion of Active and Inactive Renin in Conscious and Pentobarbitone‐anaesthetized Sheep

Haemorrhage‐induced Secretion of Active and Inactive Renin in Conscious and Pentobarbitone‐anaesthetized Sheep

Active and Inactive Renin in Critically Ill Patients

Cryoactivation Fails to Augment Plasma Renin Activity in the Cat

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