“…This value was derived from a study by Jansen and colleagues [11] where the costs associated with 467 major bypass procedures, which included aortobifemoral, iliofemoral, femorofemoral, femoropopliteal, femoroinfrapopliteal, and popliteoinfrapopliteal bypasses, were evaluated. This cost is comparable to that reported by others for major lower extremity reconstructions [12,13]. In the TOPAS trial, the number of major surgical procedures performed was 116 in the thrombolysis group and 193 in the surgery group.…”