“Inapparent” hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease

Zignego, Anna Linda; Foschi, Marco; Laffi, Giacomo; Monti, Monica; Careccia, Grazia; Romanelli, Roberto Giulio; Majo, E. De; Mazzanti, Roberto; Buzzelli, G; Villa, Giorgio La; Geñtilini, Paolo

doi:10.1002/hep.1840190306

Cited by 45 publications

(17 citation statements)

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“…In this study, occult HBV infection was not observed in the evaluated patients, and these results are in accordance with those found by ZIGNEGO et al (5) who showed that occult HBV infection is rare in Italian HBsAg-negative alcoholic patients. These same results, however, are different from those found by NALPAS et al (3) who reported a high percentage of serum positive HBV DNA in alcoholics who were negative for HBsAg and even in some who had none of the usual HBV infection markers.…”

Section: Discussionsupporting

confidence: 93%

Detection of hepatitis B virus DNA in sera from 18 alcoholic carriers of "anti-HBc alone" and response to a single dose of hepatitis B vaccine

Oliveira

Abrahão

Amorim

2008

Arq. Gastroenterol.

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-To evaluate the possibility of occult hepatitis B virus (HBV) infection in alcoholics carriers of "anti-HBc alone", and to verify the behavior of this serological pattern after a single dose of hepatitis B vaccine, 18 alcoholics who had this serological profile were evaluated by the polymerase chain reaction method, and 17 of them were vaccined. All were negative for HBV DNA. Nine (52.9%) of those vaccined had anamnestic response, mainly those with positive anti-HBe (8/10; 80%). "Anti-HBc alone" was compatible with low levels of anti-HBs in half of the patients, and probably with false positive results for anti-HBc in the others. HEADINGS -Hepatitis B, immunology. Hepatitis B virus. Alcoholism. Hepatitis B core antigens.

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Section: Discussionsupporting

confidence: 93%

Detection of hepatitis B virus DNA in sera from 18 alcoholic carriers of "anti-HBc alone" and response to a single dose of hepatitis B vaccine

Oliveira

Abrahão

Amorim

2008

Arq. Gastroenterol.

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“…Indeed, serum markers for HCV infection have been detected in 33% to 50% of alcoholic patients with evidence of liver injury, compared to only 2% to 10% in those without any sign of liver disease (4,5,7,10,13,15,21,23,24,25,26,27,30,33,35) . In the present study, anti-HCV antibodies were detected in 17 (15%) of 114 unselected alcoholic patients admitted to our detoxifi cation unit.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis C virus in alcoholic patients: role of parenteral risk factors

Galperim

Cheinquer²,

Stein³

et al. 2006

Arq. Gastroenterol.

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-Background -The prevalence of hepatitis C virus (HCV) infection is elevated in alcoholic patients, but the risk factors are unclear. The role of parenteral risk factors are indeterminated in this population. Aims -To determine the prevalence of hepatitis C virus infection in alcoholic patients admitted to a detoxifi cation unit and to evaluate the presence of underlying parenteral risk factors. Methods -A total of 114 consecutive unselected alcoholic patients admitted to a single chemical dependency unit during 14 month were included. Epidemiological data and history of parenteral risk factors for hepatitis C virus infection were obtained with a standardized questionnaire. Blood was collected for determination of aminotransferases and anti-hepatitis C virus antibodies (ELISA-3). Positive samples were confi rmed by polymerase chain reaction and tested for genotype. Results -Among the 114 alcoholics, 17 (15%) were anti-hepatitis C virus positive. Of these, 12 (71%) had detectable serum HCV-RNA by PCR. Genotype 1 was found in six cases and genotype 3 in fi ve (one patient was undetermined). Forty-nine (43%) patients had elevated serum ALT and/or AST at baseline. The comparison between the 17 positive and the 97 negative patients showed signifi cant differences in mean serum ALT levels (42 ± 41 IU/L vs. 22 ± 20 IU/L), rate of elevated ALT (65% vs. 34%), and presence of parenteral risk factors (94% vs. 10%). Comparison between alcoholic patients with and without elevated aminotransferases showed signifi cant difference only in the rate of positive anti-hepatitis C virus antibodies (24% vs. 7%). Furthermore, among the 17 anti-hepatitis C virus positive patients, the rate of detectable HCV-RNA was signifi cantly higher in the 12 with elevated aminotransferases versus the 5 with normal aminotransferases (92% vs. 20%). Conclusions -There was a high prevalence of anti-hepatitis C virus antibodies in alcoholics and the majority was confi rmed by the presence of detectable HCV-RNA. Intravenous drug use was the main risk factor for hepatitis C virus infection in this population.

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“…60 Therefore, in patients with severe acquired im- 2). HCV infection has been associated with severe liver dis- 14:195-199. ease in many studies; [76][77][78][79] …”

Section: General Population and Blood Donorsmentioning

confidence: 99%

Hepatitis C virus: Epidemiology and transmission

Heintges¹,

Wands²

1997

Hepatology

176

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come apparent because of improved diagnostic techniques Hepatitis C Virus: Epidemiology and physicians' awareness to the possibility of therapeutic intervention. This short review will focus on selected aspects and Transmission of the epidemiology and modes of transmission of HCV. MODES OF TRANSMISSIONTOBIAS HEINTGES AND JACK R. WANDS HCV is generally transmitted by the parenteral route. Well known and common modes of transmission involve transfuHepatitis C virus (HCV) is an RNA virus with a genomic size of 9.6 kb. More than 50% of individuals exposed to HCV sions and/or parenteral contact with blood products. 1 However, up to 50% of individuals deny exposure to any of these develop chronic infection. Of those individuals chronically infected, approximately 20% to 30% will develop liver cirrho-known risk factors, and infection is often designated as ''community acquired.'' 1 Before the initiation of HCV antibody sis and/or hepatocellular carcinoma when followed for twenty to thirty years. Methods to identify HCV include a screening, approximately 10% to 20% of individuals, who had received multiple blood transfusions or plasma products, highly sensitive third generation immunoassay that detects antibodies to structural and nonstructural proteins in serum. seroconverted to anti-HCV positive. Thus, the relative risk was 0.45% per unit transfused. 2,3 However, the introduction Viremia may be detected by reverse transcriptase-polymerase chain reaction (RT-PCR) technology. The role of HCV of routine HCV antibody screening of blood products has led to a sharp decrease in the transmission rate of HCV. For infection in acute and chronic liver disease has recently be FIG. 1. World map illustrating the prevalence of HCV antibodies in blood donors as measured by second or third generation assays. 35,[38][39][40][41][42][43][44][45][46][47][48][49][50]57,74,[85][86][87][88][89][90][91][92][93][94][95] Abbreviations: HCV, hepatitis C virus; HIV, human immunodeficiency virus.

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“Inapparent” hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease

Cited by 45 publications

References 30 publications

Detection of hepatitis B virus DNA in sera from 18 alcoholic carriers of "anti-HBc alone" and response to a single dose of hepatitis B vaccine

Detection of hepatitis B virus DNA in sera from 18 alcoholic carriers of "anti-HBc alone" and response to a single dose of hepatitis B vaccine

Prevalence of hepatitis C virus in alcoholic patients: role of parenteral risk factors

Hepatitis C virus: Epidemiology and transmission

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