Inappropriate Secretion of Thyroid Stimulating Hormone in a Filipino Patient with a Pituitary Macroadenoma

Abstract

Pituitary tumors producing thyrotropin are very rare. We report a case of a 38-year-old, male admitted for seizure, preceded by 1 week history of generalized weakness, fatigue, anorexia, nausea and vomiting, with a 5 year history of recurrent headache followed by blurring of vision, who was found to have persistently elevated serum free thyroid hormones and non-suppressed thyroid stimulating hormone (TSH) levels, with tumor residual after craniotomy with excision of the pituitary macroadenoma. To our knowledge, this is the first reported case of TSH-producing adenoma in the Philippines.

Pituitary Adenoma in the Philippines: A Scoping Review on the Treatment Gaps, Challenges, and Current State of Care

“…With its increasing incidence and prevalence, and its potential to cause significant morbidity, this type of tumor may impose a heavy burden on both patients and their families as well as on health care systems [ 1 ]. Symptoms usually arise from compression of adjacent structures (blurring of vision, visual field defects, diplopia, increased intracranial pressure) as well as signs and symptoms of deficient or excess hormone production [ 2 , 3 , 4 ]. In recent studies, pituitary adenomas have been found to comprise approximately 10–15% of brain tumors, being the third most common intracranial neoplasm after meningiomas and gliomas [ 2 , 5 ].…”