Inappropriate treatment response to DMARDs: A pathway to difficult-to-treat rheumatoid arthritis

Guo, Hongtao; Liu, Bin; Lu, Peipei; Cao, Zhiwen; Ji, Xinyu; Li, Li; Ouyang, Guilin; Nie, Zhiqiang; Lu, Aiping; Lü, Cheng

doi:10.1016/j.intimp.2023.110655

Cited by 7 publications

(3 citation statements)

References 119 publications

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“…15,16 Furthermore, the exorbitant expenses and significant adverse effects pose numerous obstacles for DMARDs employment in the treatment of RA. 17 Selegiline is a chemical moiety having approval from the FDA for treating Parkinson's disease as an adjuvant and major depressive disorder in adults. Its primary mechanism of action involves the inhibition of monoamine oxidase (MAO) impeding the process of reuptake of monoamine neurotransmitters inside the central nervous system, leading to an increase in the quantities of physiologically active monoamines present at the synaptic cleft.…”

Section: Introductionmentioning

confidence: 99%

Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats

Ahmed,

Chetia

2024

Eur J Clin Exp Med

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Introduction and aim. Rheumatoid arthritis (RA) causes pain, inflammation, and deformities in numerous joints. Monoamine oxidase B (MOA-B) inhibitor selegiline exhibits anti-inflammatory characteristics and has the propensity to scavenge free radicals. Therefore, the aim of this research comprises of assessing the effect of selegiline on proinflammatory cytokines in RAW 264.7 macrophages as well as its capacity to improve various arthritic parameters in rats with lipopolysaccharide (LPS) accelerated complete Freund’s adjuvant (CFA) induced RA. Material and methods. In RAW 264.7 cells (lipopolysaccharide accelerated), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and prostaglandin E2 (PGE2 ) were determined after treat ment with selegiline. Different arthritic parameters were analyzed after administration of selegiline in LPS accelerated CFA-induced arthritis in rats. Results. LPS escalates NO, TNF-α, IL-6, iNOS, and PGE2 quantities in the RAW 264.7 cells, which was minimized by selegiline at 100 µg/mL and 150 µg/mL respectively. In rats, CFA induction causes a decrease in body weight, elevation of paw volume, splenic index, and arthritic index, which are further accelerated by LPS. 20 mg/kg of selegiline managed all these arthritic parameters effectively, including TNF-α, IL-6, and a few other biochemical parameters. Conclusion. Selegiline may be beneficial in RA extenuating joint and cartilage damage, and modulating inflammatory responses.

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Section: Introductionmentioning

confidence: 99%

Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats

Ahmed,

Chetia

2024

Eur J Clin Exp Med

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“…This genus is known to possess various biological activities, such as analgesic [20][21][22], anti-inflammatory [22][23][24], gastroprotective [25,26], and antimicrobial effects [27][28][29], among others. Among these species, we have Psidium glaziovianum, commonly known as araçápitanga, which grows in the northeastern and southeastern regions of Brazil; this species is known for its edible fruits, which are similar to guavas, and it is also used in traditional medicine for various purposes [30].…”

Section: Introductionmentioning

confidence: 99%

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Costa,

Alves,

Fonseca

et al. 2024

DDC

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Rheumatoid arthritis (RA) is a chronic and debilitating condition that affects a significant number of individuals worldwide. Unfortunately, the currently available therapeutic approaches often yield unsatisfactory results and may be accompanied by harmful side effects. A medicinal plant called Psidium glaziovianum Kiaersk has potential benefits in the treatment of this condition due to its anti-inflammatory and analgesic properties. In this study, our objective was to investigate the potential therapeutic effects of P. glaziovianum essential oil (PgEO) in alleviating arthritis symptoms in mice induced by Complete Freund’s Adjuvant (CFA). The effect of P. glaziovianum essential oil was evaluated in mice with Complete Freund’s Adjuvant (CFA)-induced arthritis. Edema sizes, macroscopic and radiographic images, cytokine levels, and oxidative stress were evaluated. Administration of PgEO at dosages of 50 and 100 mg/kg effectively prevented CFA-induced osteoarticular changes in arthritic mice, resulting in a significant reduction in joint damage. Additionally, the PgEO treatment exhibited the ability to minimize edema, a common symptom associated with arthritis. Furthermore, PgEO can modulate the levels of pro-inflammatory cytokines and oxidative stress, both of which play crucial roles in the progression of the disease. In conclusion, our study suggests that PgEO holds great potential as a natural therapeutic agent for rheumatoid arthritis.

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“…АИЗ существенно снижают качество жизни пациентов, могут приводить к инвалидизации и летальному исходу. Несмотря на определенные успехи, терапия аутоиммунных заболеваний по-прежнему является вызовом, и интерес к разработке новых методов лечения только растет [1,2].…”

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Prospects for microbiome modulation in autoimmune diseases: a literature review

Peshkova,

Korneev,

Koteneva

et al. 2024

jour

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Autoimmune diseases are characterized by dysregulation of immune responses and damage to healthy body tissues. Their complete cure remains elusive, and existing therapies are often accompanied by side effects. Recent studies have shown a signifi cant role of disturbances in the composition of the microbiome in the development of autoimmune reactions. Moreover, modulation of the microbiome through various therapeutic interventions represents a promising direction in the framework of complex therapy of the underlying disease. Extracellular vesicles, in particular exosomes, transport biologically active substances between cells, and a number of studies have shown their therapeutic effect in autoimmune diseases. However, the role of extracellular vesicles in modulating the microbiome remains poorly understood, and further research is needed to better understand their impact on the pathogenesis of autoimmune diseases and associated microbiome changes, as well as to develop new treatment strategies. The presented literature review, based on a study of English-language sources, examines the importance of the microbiota of different loci of the human body (intestines, skin, oral cavity) in the development of autoimmune diseases such as multiple sclerosis, psoriasis and Sjögren’s disease. The role of extracellular vesicles in modulating the microbiome during autoimmune diseases therapy is discussed.

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Inappropriate treatment response to DMARDs: A pathway to difficult-to-treat rheumatoid arthritis

Cited by 7 publications

References 119 publications

Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats

Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

Prospects for microbiome modulation in autoimmune diseases: a literature review

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