2018
DOI: 10.1007/s40266-018-0541-7
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Inappropriate Use of Antimicrobials for Lower Respiratory Tract Infections in Elderly Patients: Patient- and Community-Related Implications and Possible Interventions

Abstract: The elderly are more susceptible to infections, which is reflected in the incidence and mortality of lower respiratory tract infections (LRTIs) increasing with age. Several aspects of antimicrobial use for LRTIs in elderly patients should be considered to determine appropriateness. We discuss possible differences in microbial etiology between elderly and younger adults, definitions of inappropriate antimicrobial use for LRTIs currently found in the literature, along with their results, and the possible negativ… Show more

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Cited by 7 publications
(9 citation statements)
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“…These alterations induce a basal systemic inflammatory state, or “inflammaging” ( 110 ), and are associated with an augmented susceptibility to viral infection ( 111 ). High morbidity and mortality are observed in elderly patients with infections, especially those of the respiratory tract ( 112–114 ). This situation could be prevented through vaccination; however, vaccine efficacy in this population is greatly reduced in comparison to that in younger adults ( 115–119 ).…”
Section: Aging and Nutrition And Covid-19mentioning
confidence: 99%
“…These alterations induce a basal systemic inflammatory state, or “inflammaging” ( 110 ), and are associated with an augmented susceptibility to viral infection ( 111 ). High morbidity and mortality are observed in elderly patients with infections, especially those of the respiratory tract ( 112–114 ). This situation could be prevented through vaccination; however, vaccine efficacy in this population is greatly reduced in comparison to that in younger adults ( 115–119 ).…”
Section: Aging and Nutrition And Covid-19mentioning
confidence: 99%
“…Antimicrobial resistance (AMR) is accelerated upon misuse and overuse of antimicrobial agents [ 2 ]. Many reports from different parts of the world indicated a high prevalence of inappropriate or incorrect use of antibiotics both in hospitals and in primary healthcare centers [ 3 8 ]. The Global Action Plan (GAP) on AMR, endorsed by the World Health Organization (WHO) in 2015, considered the optimization of antimicrobial use as one of the important strategic objectives that should be included in developing national action plans to combat AMR [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…Although AMR is alarming for the whole population, it is likely to pose more serious threats to groups at greater overall risk of contracting infections or infectious diseases, and indeed appropriateness of antimicrobial prescribing for therapeutic or prophylactic purposes has been thoroughly investigated in more vulnerable populations, such as hospitalized patients [ 3 ], subjects with underlying clinical conditions, namely chronic conditions such as heart disease, cancer, hypertension, diabetes, etc. [ 4 , 5 ], institutionalized elderly [ 6 , 7 ], and children [ 8 ].…”
Section: Introductionmentioning
confidence: 99%