Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity

An integrated bioinformatics analysis reveals IRF8 as a critical biomarker for immune infiltration in atherosclerosis advance

“…Of note, IRF8 is a member of a family of nine transcription factors characterized by a conserved N‐terminal domain 16,36,37 . Although STAT1 is expressed widely, IRF8 expression is observed in lymphoid‐cell lineages as well as in various other tissue types, including the brain and heart 38–40 . IFNγ and TLR4‐A are key factors in starting atherosclerosis and plaque formation by activating STAT and IRF transcription factors that regulate the immune response 41–44 .…”

“…16,36,37 Although STAT1 is expressed widely, IRF8 expression is observed in lymphoidcell lineages as well as in various other tissue types, including the brain and heart. [38][39][40] IFNγ and TLR4-A are key factors in starting atherosclerosis and plaque formation by activating STAT and IRF transcription factors that regulate the immune response. [41][42][43][44] Specifically, STAT1 and IRF8 have emerged as key regulators of inflammation, particularly within immune cell populations.…”