Inbred low anxiety-related behavior (LAB) mice – a mouse model of attention-deficit hyperactivity disorder (ADHD)?

Yen, Yi-Chun; Anderzhanova, Elmira; Kleinknecht, K.; Bunck, Mirjam; Micale, Vincenzo; Landgraf, Rainer; Wotjak, Carsten T.

doi:10.1055/s-0031-1292565

Cited by 2 publications

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“…HAB animals exhibit increased CRF mRNA expression in hypothalamic nuclei following prenatal stress [10] and increased stress susceptibility [11] as well as hyperactivity along the hypothalamic pituitary adrenal (HPA) axis following stress [12]. Moreover, HAB rats also show elevated Fos immunoreactivity in the hypothalamus following anxiety provoking stimuli [13] and increased expression of the neuropeptide cocaine and amphetamine regulated transcript (CART) in the hypothalamus [14] which may contribute to increased sensitivity to amphetamine-induced locomotion [15]. These findings suggest that individual differences in anxiety-like behavior involve activation along the HPA axis that may contribute to psychostimulant drug vulnerability.…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Ravenelle

Byrnes

et al. 2013

Behavioural Brain Research

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Environmental enrichment attenuates the response to psychostimulants and has been shown to reduce both anxiety and stress-related behaviors. Since stress is a major vulnerability factor for addiction, we investigated whether enrichment could reverse stress profiles in high anxious rats as well as reduce their amphetamine sensitivity. Using selectively-bred high and low anxiety males (filial 3) from enriched, social or isolated environments, we tested elevated plus maze exploration, novelty place preference and amphetamine (AMPH; 0.5 mg/kg, IP)-induced hyperactivity. We measured plasma corticosterone (CORT) response after forced novel object exposure, phosphorylation of the tropomyosin-related kinase B receptor (pTrkB) in the hippocampus and striatum, and dopamine (D2) receptor mRNA levels in the striatum and nucleus accumbens. Results indicate that high anxiety animals reared in social or enriched environments spent more time on open arms of the EPM while low anxiety animals raised in enriched environments spent more time on open arms when compared to either isolated or social groups. There were no group differences or interactions found for novelty place preference. Enriched environments decreased the response to AMPH and stress-induced CORT regardless of trait but selectively decreased pTrkB and increased D2 mRNA levels in high anxiety animals. The results suggest that selectively-bred trait anxiety rats show state anxiety that is influenced by rearing environments, and D2 protein levels and BDNF/TrkB signaling may differentially contribute to integrating these effects.

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Section: Introductionmentioning

confidence: 99%

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Ravenelle

Byrnes

et al. 2013

Behavioural Brain Research

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“…In accordance with this possibility, a research group at the Max Planck Institute of Psychiatry (Munich, Germany) developed a mouse model of extreme trait anxiety, based on selective breeding for low, normal, and high open-arm exploration in the elevated plus maze. Pharmacological and behavioral results indicated that genetically selected low anxiety-related behavior might indeed represent an animal of ADHD [102,103].…”

Section: Fos Expression In Clf Animalsmentioning

confidence: 99%

Distinct patterns of brain Fos expression in Carioca High- and Low-conditioned Freezing Rats

et al. 2020

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Background The bidirectional selection of high and low anxiety-like behavior is a valuable tool for understanding the neurocircuits that are responsible for anxiety disorders. Our group developed two breeding lines of rats, known as Carioca High-and Low-conditioned Freezing (CHF and CLF), based on defensive freezing in the contextual fear conditioning paradigm. A random selected line was employed as a control (CTL) comparison group for both CHF and CLF lines of animals. The present study performed Fos immunochemistry to investigate changes in neural activity in different brain structures among CHF and CLF rats when they were exposed to contextual cues that were previously associated with footshock. Results The study indicated that CHF rats expressed high Fos expression in the locus coeruleus, periventricular nucleus of the hypothalamus (PVN), and lateral portion of the septal area and low Fos expression in the medial portion of the septal area, dentate gyrus, and prelimbic cortex (PL) compared to CTL animals. CLF rats exhibited a decrease in Fos expression in the PVN, PL, and basolateral nucleus of the amygdala and increase in the cingulate and perirhinal cortices compared to CTL animals. Conclusions Both CHF and CLF rats displayed Fos expression changes key regions of the anxiety brain circuitry. The two bidirectional lines exhibit different pattern of neural activation and inhibition with opposing influences on the PVN, the main structure involved in regulating the hypothalamic-pituitary-adrenal neuroendocrine responses observed in anxiety disorders.

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Inbred low anxiety-related behavior (LAB) mice – a mouse model of attention-deficit hyperactivity disorder (ADHD)?

Cited by 2 publications

References 0 publications

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Environmental enrichment effects on the neurobehavioral profile of selective outbred trait anxiety rats

Distinct patterns of brain Fos expression in Carioca High- and Low-conditioned Freezing Rats

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