Inbred Mice in Science

Strong, Leonell C.

doi:10.1016/b978-0-12-507850-4.50011-1

Cited by 31 publications

(19 citation statements)

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“…C3H and C57BR mice were MHC donors for the BALB.K and B10.BR MHC congenic lines, respectively. The C3H strains were developed by Strong from a cross of a Bagg albino female with a DBA stock and then selected for a high incidence of mammary tumors (21). C57BR was inbred from the brown subline of the same cross that gave rise to founders for the C57BL strains.…”

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confidence: 99%

Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice

Cao

Lo²,

Ranheim³

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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MHC typing for human hematopoietic cell transplantation (HCT) from unrelated donors is currently performed by using a combination of serologic and molecular techniques. It has been determined that allelic differences in human MHC molecules, revealed by nucleotide sequencing but not by serologic typing, substantially influence graft rejection and graft-versus-host disease, two serious complications of clinical HCT. We studied transplantation of purified hematopoietic stem cells in a series of mouse strains that were matched at the MHC but had different background genes, and we observed striking differences in engraftment resistance and graftversus-host disease severity, both factors depending on the donorrecipient strain combination. The individual mouse lines studied here were established nearly a century ago, and their MHC types were determined exclusively by serologic techniques. We considered the possibility that serologically silent MHC polymorphisms could account for our observations and, therefore, we performed DNA sequencing of the class I and II MHC alleles of our mouse strains. At each locus, exact homology was found between serologically MHC-matched strains. Our results likely extend to all serologically MHC-matched mouse strains used in modern research and highlight the profound and variable influence that non-MHC genetic determinants can have in dictating outcome after HCT.histocompatibility antigens ͉ hematopoietic stem cell transplantation I n clinical allogeneic hematopoietic cell transplantation (HCT), matching of donors and recipients at the MHC is considered essential to minimize graft-versus-host disease (GVHD) and graft rejection. Related donors are usually siblings who have inherited the same parental alleles and thus encode MHC molecules (designated HLA in humans) genotypically identical to the patient. Because related donors are often unavailable, MHC-matched unrelated donors are sought by volunteer bone marrow (BM) donor registries. Historically, human MHC typing has been performed by using panels of alloantibodies derived from individuals exposed to HLAs by pregnancy or transfusion (1). In the last decade, such serologic typing has given way to the more precise DNA-based technology, which has revealed that in Ͼ20% of serologically matched unrelated donors, sequence polymorphisms exist in class I and͞or class II MHC molecules (2-7). Thus, serologically defined HLAs can encode families of alleles whose differences are distinguishable only by DNA-based typing methods. These polymorphisms encode amino acid substitutions that cluster within the MHC peptide binding groove and, although serologically silent (2, 8), can influence T cell activation. It has been shown in human HCT that the consequences of these serologically undetectable differences include increased risks of GVHD and mortality when the disparities are in the MHC class II loci (7, 9) and increased graft failures in the cases of MHC class I disparities (2, 3, 10).Polymorphisms at non-MHC genes encoding for minor histocompatibility ...

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confidence: 99%

Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice

Cao

Lo²,

Ranheim³

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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“…About 10 years later strain C57BL/6 was established by Miss Abbie Lathrop of Granby, Massachusetts (USA) intercrossing the 'black' offspring of her female 57, while strains C3H, CBA and A were created by L. C. Strong, a cancer geneticist established at Cold Spring Harbor Laboratory [48]. At this point it is interesting to note that, among the strains established by L. C. Strong, strains CBA and C3H stemmed from the offspring of an out-cross with a few wild specimens trapped in a pigeon coop in Cold Spring Harbor.…”

Section: Mouse Interspecific Hybridizationmentioning

confidence: 99%

Origins and Phylogenetic Relationships of the Laboratory Mouse

Guénet¹,

Orth²,

Bonhomme³

2012

The Laboratory Mouse

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“…La variance phénotypique devrait alors être réduite. Ces réflexions l'amène à croiser pendant plusieurs géné-rations une série de frères-soeurs, ce qui aboutira à la fabrication de la lignée consanguine C3H (Strong, 1978). Strong effectue ce travail dans des conditions très difficiles.…”

Section: Les Premières Populations Génétiques De Référence : Les Lignunclassified

Comment la souris est devenue, timidement, une espèce modèle pour la recherche en génétique animale et humaine

Panthier¹,

Guénet²

2016

bavf

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Depuis le début du vingtième siècle, le modèle souris est l'un des plus communément utilisés par les généticiens. Cet article retrace les origines des recherches en Génétique de la Souris, et présente ses liens avec les travaux les plus actuels en Biologie expérimentale. Après les premières analyses formelles par Lucien Cuénot, William E. Castle, Clarence C. Little, et John B. S. Haldane, les généticiens se sont lancés dans la production de lignées consanguines. Cette histoire se prolonge jusqu'à nos jours avec la production de nouvelles populations de référence présentant une diversité génétique très élevée : le Collaborative Cross, et le Diversity Outbred. Dans le même temps, Leroy Stevens, Martin Evans, Gail Martin, et Barry Pierce réalisent une série d'expériences cruciales sur une tumeur rare : le tératocar-cinome. Ces tumeurs vont être placées au coeur de recherches passionnantes qui se poursuivent de nos jours encore avec les travaux qui visent à comprendre les mécanismes de la reprogrammation des cellules somatiques adultes en cellules pluripotentes. Mots

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Inbred Mice in Science

Cited by 31 publications

References 0 publications

Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice

Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice

Origins and Phylogenetic Relationships of the Laboratory Mouse

Comment la souris est devenue, timidement, une espèce modèle pour la recherche en génétique animale et humaine

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