Inbreeding and Sex Ratio in two Captive Colonies of Dicrostonyx Torquatus Pall., 1779: A Reply to G. H. Jarrell

Gileva, E. A.

doi:10.1111/j.1601-5223.1998.00185.x

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Moreover, because systems of distortion loci and their responders coevolve rapidly and can generate Dobzhansky–Muller incompatibilities, they may play an important role in the evolution of reproductive isolation ( Frank 1991 ; Hurst and Pomiankowski 1991 ). On the X chromosome, segregation distortion loci can influence sex ratios and even lead to novel sex-determining mechanisms ( Jarrell 1995 ; Gileva 1998 ; Hurst and Werren 2001 ). Thus, understanding the prevalence of TD is important for many aspects of evolutionary genetics.…”

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Evaluating the Evidence for Transmission Distortion in Human Pedigrees

et al. 2012

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Children of a heterozygous parent are expected to carry either allele with equal probability. Exceptions can occur, however, due to meiotic drive, competition among gametes, or viability selection, which we collectively term “transmission distortion” (TD). Although there are several well-characterized examples of these phenomena, their existence in humans remains unknown. We therefore performed a genome-wide scan for TD by applying the transmission disequilibrium test (TDT) genome-wide to three large sets of human pedigrees of European descent: the Framingham Heart Study (FHS), a founder population of European origin (HUTT), and a subset of the Autism Genetic Resource Exchange (AGRE). Genotyping error is an important confounder in this type of analysis. In FHS and HUTT, despite extensive quality control, we did not find sufficient evidence to exclude genotyping error in the strongest signals. In AGRE, however, many signals extended across multiple SNPs, a pattern highly unlikely to arise from genotyping error. We identified several candidate regions in this data set, notably a locus in 10q26.13 displaying a genome-wide significant TDT in combined female and male transmissions and a signature of recent positive selection, as well as a paternal TD signal in 6p21.1, the same region in which a significant TD signal was previously observed in 30 European males. Neither region replicated in FHS, however, and the paternal signal was not visible in sperm competition assays or as allelic imbalance in sperm. In maternal transmissions, we detected no strong signals near centromeres or telomeres, the regions predicted to be most susceptible to female-specific meiotic drive, but we found a significant enrichment of top signals among genes involved in cell junctions. These results illustrate both the potential benefits and the challenges of using the TDT to study transmission distortion and provide candidates for investigation in future studies.

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Evaluating the Evidence for Transmission Distortion in Human Pedigrees

et al. 2012

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Sex ratios in birds and mammals: can the hypotheses be disentangled?

2002

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Conservation Genetics of Nordic Carnivores: Lessons from Zoos

Laikre

2004

Hereditas

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This paper summarizes results from genetic studies of Nordic carnivore populations bred in captivity. The conservation genetic implications of those results for the management of wild populations of the same species are discussed. Inbreeding depression has been documented in the brown bear (Ursus arctos), wolf (Canis lupus), and lynx (Lynx lynx) populations held in Nordic zoos. The characters negatively affected by inbreeding include litter size (brown bear and wolf), longevity (lynx and wolf), female reproduction, and weight (wolf). In addition, hereditary defects caused by single autosomal alleles occur in the wolf and brown bear populations. These deleterious alleles cause blindness (wolf) and albinism (brown bear) in the homozygous state. The amount of inbreeding depression observed in Nordic carnivores are similar to that documented in other species. The captive populations have the same genetic background as the current wild ones and inbreeding depression is therefore a potential threat to wild carnivore populations in Sweden. This threat is presently not being adequately recognized in the management of these species. Frequently occurring misunderstandings regarding the kind of conclusions that can be drawn from the presented genetic observations are also discussed.

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Inbreeding and Sex Ratio in two Captive Colonies of Dicrostonyx Torquatus Pall., 1779: A Reply to G. H. Jarrell

Cited by 3 publications

References 11 publications

Evaluating the Evidence for Transmission Distortion in Human Pedigrees

Evaluating the Evidence for Transmission Distortion in Human Pedigrees

Sex ratios in birds and mammals: can the hypotheses be disentangled?

Conservation Genetics of Nordic Carnivores: Lessons from Zoos

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