Inbreeding depression in the Lizard canary breed estimated by pedigree analysis

Cecchi, Francesca; Giacalone, G.; Paci, Gisella

doi:10.17221/8664-cjas

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…Line-breeding and selection in dogs have successfully led to desirable phenotypic traits. However, they have also had the unintended consequence of increasing inbreeding, which in turn can increase genetic monofactorial and multifactorial diseases (Cecchi et al 2020) and lead to inbreeding depression (Ólafsdóttir and Kristjánsson 2006) on fitness (Brzeski et al 2014;Cecchi et al 2016a), production (Leroy 2014) and morphological traits (Gandini et al 1992;Gómez et al 2009;Wolc and Baliñska 2010;Cecchi et al 2018).…”

Section: Introductionmentioning

confidence: 99%

A genealogical survey on the main bloodline of the Australian Cattle Dog in Italy

Ciccarelli

Macchioni

Cecchi

2021

Rend. Fis. Acc. Lincei

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This paper presents the results of genetic variability analyses using genealogical data on the main genetic bloodline of the Australian Cattle Dog in Italy, a line that has had a significant impact on the development of the breed. All the genealogical data on the progeny and ancestors of one of the first stallions introduced in Italy were considered, i.e. Cattlefarm's Comeback Jack born on 1/2/1997 in Finland. Animals from the bloodline born between 1962 and 2019 were considered. A total number of 1722 animals were found to be from the line which represents the entire population (WP), including the basic population (BP) and the reference population (RP) defined as the animals currently living. A total of 982 animals were in the RP, with the oldest living dogs born in 2004. A total of 854 dogs were inbred. The average inbreeding coefficient (F) in the RP was 5.1%, while the average inbreeding of the inbred animals was 5.8%. The F was < 0.10 in 711 dogs (77.3% of inbred), and > 0.20 in only 36 dogs (3.91% of inbred). Fifteen traced generations were highlighted. A maximum average inbreeding value (6.45%) was observed in the dogs with 11 traced generations. This research highlighted the good genetic variability of this Australian Cattle Dog bloodline thanks to the efficient management of the breeders who in the past introduced some stallions from abroad. Currently, the lines in Italy are not sufficiently high to prevent inbreeding in the new matings, which is becoming frequent. It is, therefore, important to continue to import new stallions for reproduction to expand the genetic variability. However, at the same time, the old lines need to be preserved genetically, aptitudinally and morphologically, as they are an important heritage of the breed in Italy.

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Section: Introductionmentioning

confidence: 99%

A genealogical survey on the main bloodline of the Australian Cattle Dog in Italy

Ciccarelli

Macchioni

Cecchi

2021

Rend. Fis. Acc. Lincei

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“…Inbreeding depression, the reduced fitness of inbred individuals (Charlesworth & Charlesworth, ), can contribute to genetic Allee effects, a positive correlation between population size and fitness (Luque et al., ; Wittmann, Stuis, & Metzler, ), and can hence increase the risk of extinction of small and/or declining populations. Because inbred individuals have an increased probability of expressing recessive deleterious mutations or homozygous genotypes at over‐dominant genes (Charlesworth & Charlesworth, ), they usually have low survival (Cecchi, Giacalone, & Paci, ; Norén, Godoy, Dalén, Meijer, & Angerbjörn, ), reproduction (Norén et al., ) and/or poor body condition (Brommer, Kekkonen, & Wikström, ; Gholizadeh & Ghafouri‐Kesbi, ). Lower values of life‐history traits can in turn affect population growth (Gaillard, Festa‐Bianchet, Yoccoz, Loison, & Toïgo, ).…”

Section: Introductionmentioning

confidence: 99%

“…Inbreeding depression is traditionally studied with the help of exhaustive pedigrees, requiring long‐term monitoring of populations and extensive knowledge of many kinship relations among individuals (Cecchi et al., ; Norén et al., ; Silió, Barragán, Fernández, García‐Casco, & Rodríguez, ). Although this approach directly assesses inbreeding, it is costly and often unrealistic to produce pedigrees for natural populations (but see Charmantier, Garant, & Kruuk, ).…”

Section: Introductionmentioning

confidence: 99%

No evidence of inbreeding depression in fast declining herds of migratory caribou

Gagnon

Yannic

Perrier

et al. 2019

J of Evolutionary Biology

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Identifying inbreeding depression early in small and declining populations is essential for management and conservation decisions. Correlations between heterozygosity and fitness (HFCs) provide a way to identify inbreeding depression without prior knowledge of kinship among individuals. In Northern Quebec and Labrador, the size of two herds of migratory caribou (Rivière‐George, RG and Rivière‐aux‐Feuilles, RAF) has declined by one to two orders of magnitude in the last three decades. This raises the question of a possible increase in inbreeding depression originating from, and possibly contributing to, the demographic decline in those populations. Here, we tested for the association of genomic inbreeding indices (estimated with 22,073 SNPs) with body mass and survival in 400 caribou sampled in RG and RAF herds between 1996 and 2016. We found no association of individual heterozygosity or inbreeding coefficient with body mass or annual survival. Furthermore, those genomic inbreeding indices remained stable over the period monitored. These results suggest that the rapid and intense demographic decline of the herds did not cause inbreeding depression in those populations. Although we found no evidence for HFCs, if demographic decline continues, it is possible that such inbreeding depression would be triggered.

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“…In the selection, the inbreeding is used as a mating method because it allows fixing the characteristics and traits of the best representatives of a breed. However, this method can produce inbreeding depression, which has been described as a potential animal welfare problem (Keller and Waller, 2002;Brzeski et al, 2014;Cecchi et al, 2016) reducing fertility (Langlois and Blouin, 2004;Gonzales-Recio et al, 2007;Sairanen et al, 2009) and can lead to a decrease in selection response for economic traits such as racing performance (Todd et al, 2018). As the creation of Arab horse was not based on crossbreeding, it is more exposed to inbreeding effects than other horse breeds (Budzyński et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Effect of inbreeding on the “Club Foot” disorder in Arabian Pureblood horses reared in Italy

Comparini¹,

Podestà²,

Russo³

et al. 2019

Open Vet J.

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Background: "The Club Foot" (or "Mismatched Foot") is an acquired or congenital flexural deformity of the distal interphalangeal joint, caused by a shortening of the musculotendinous unit of the deep digital flexor tendon. Aim: The aim of this research was to detect the incidence of the disorder in Arabian Pureblood horses, attempting to understand its causes and to analyze a possible role of inbreeding in its expression. In this breed, in fact, the pathology is widespread because in the environment of origin, the rocky desert, a hard and almost goat's hoof is not disabling so the selection against this disorder has never been done. Methods: Pedigrees were taken from 141 (reference population = RP) adult Arabian Pureblood horses (51 males and 90 females) belonging to eight Italian different farms during the period 1982-2017. For each horse, the presence or not of the disorder was observed and inbreeding coefficients (F) was performed. Four grades of deformity were considered. Moreover, the environmental condition of each farm was considered: boxes, paddocks, nutrition, orientation, and hoof care and shoeing. The chi-square test was applied. Analysis of variance (ANOVA) was used to test the differences in the average inbreeding coefficient (F) between affected and healthy animals, between sexes and between shod and unshod animals. Results: Two grades of deformity were observed (I and II) which give less severe manifestations, with 28 females and 25 males (37.59% of the examined horses) showing the disorder. No differences between males and females or between shod (38.29%) and unshod (61.70%) were observed. Environmental conditions do not influence the rate of pathology in the different farms, with a prevalence of the disorder ranging from 7.69% up to 100% on farm. The whole population (WP = RP and its genealogy) included 3,355 records subdivided in seven traced generations. One hundred and eighteen out of 141 horses (RP) were inbred (83.69%). The average inbreeding coefficient (F) in the RP was 0.095. Inbreeding coefficient in RP was <0.05 in only 15 horses (12.71% of inbred), whereas it was >0.25 in 28 horses (23.73% of inbred). Conclusion: High inbreeding coefficients were observed in all farms and in particularly in affected animals suggesting that high inbreeding coefficients increases the probability that the disorder occurs. Future works may include the study of the hereditability of the character, and the attempt to identify loci associated with the disorder.

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Inbreeding depression in the Lizard canary breed estimated by pedigree analysis

Cited by 9 publications

References 26 publications

A genealogical survey on the main bloodline of the Australian Cattle Dog in Italy

A genealogical survey on the main bloodline of the Australian Cattle Dog in Italy

No evidence of inbreeding depression in fast declining herds of migratory caribou

Effect of inbreeding on the “Club Foot” disorder in Arabian Pureblood horses reared in Italy

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