Inbreeding effect on mortality and morbidity in South Brazilian populations*

Marclallo, F. A.; Freire‐Maia, N.; Azevedo, J.B.C.; Simões, I. A.

doi:10.1111/j.1469-1809.1963.tb00787.x

Cited by 25 publications

(8 citation statements)

References 17 publications

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“…Consanguineous marriages are still preferred in many major human populations (Bittles, 1994). Consanguineous marriages represent inbreeding in human populations and, as this leads to increased homozygosity, consanguineous marriages due to homozygosity of recessive lethal, sublethal and detrimental alleles result in increased risk of early mortality and morbidity (Morton, 1958;Marcallo et al, 1964). Some authors have, however, highlighted the difficulty in separating genetic effects from the sociological correlates of consanguineous marriages (Morton, Crow & Muller, 1956;Fraser & Biddle, 1976;Alstrom, 1977;Bittles, 1993).…”

Section: Introductionmentioning

confidence: 99%

Biosocial perspective of consanguineous marriages in rural and urban swat, Pakistan

Wahab¹,

Siddique

1996

J. Biosoc. Sci.

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SummaryConsanguineous marriages in two population samples, one rural and one urban, from Swat (Pakistan) were studied. The frequency of consanguineous marriages was found to be 37·13% and 31·11%, and mean inbreeding coefficients were calculated as 0·0168 and 0·0162, for the rural and urban populations respectively. The most frequent type of marriage was between first cousins, in both samples. Among first cousin marriages, those with father's brother's daughter were predominant. Mean inbreeding coefficient was higher for higher socioeconomic groups in both samples. Differences by ethnic and educational groups were also found. Contrary to previous studies, a significant increase in the incidence of consanguineous marriages over the years has been observed. The incidence of premature mortality was significantly higher only in the offspring of first cousin marriages. Significantly higher incidence of morbidity in the offspring of consanguineous marriages was also observed.

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Section: Introductionmentioning

confidence: 99%

Biosocial perspective of consanguineous marriages in rural and urban swat, Pakistan

Wahab¹,

Siddique

1996

J. Biosoc. Sci.

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“…1958;Sutter and T a ba h , 1952; M o r t o n , 1961; M a rca llo el al., 1964;Sc h u l l and N eel, 1965], Sang h v i [1966] was the first to report on the quantitative data on consanguineous marriages in Tndia at the World Population Conference. Since then Sanghvi [1966] and many other Indian geneticists ; C h a k r a v a r ih i, 1968; C en ter w a ll et a i, 1969;D ronam R aju etaI., 1961;G osw a m i, 1970;M ukherjef.…”

Section: Introductionmentioning

confidence: 99%

Effects of Parental Consanguinity on Fertility, Mortality and Morbidity among the Pattusalis of Tirupati, South India

Reddy¹,

Rao²

1978

Hum Hered

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“…Diverse reasons have been projected as explanation for the lower rates of prenatal mortality which include a) genes responsible for foetal death are smaller in number, b) the developing foetus is well protected against genes that are capable of foetal impairment, c) lethal genes are less operating prentally in man etc. (Marcello et al,1964;Schull, 1959). On comparing the mortality levels of the present tribal groups with those reported in a few other inbreeding communities in the State (Pillai and Mathew, 1995;Sudhakaran and Vijayavalli, 1996) in association with the respective consanguinity rates it is apparent that there is a positive association between the two parameters, farley high rates occuring in communities with high inbreeding rates and vice versa.…”

Section: Resultsmentioning

confidence: 49%

Effects of Inbreeding in the Mudugar and Irular Tribal Populations in Kerala

Joseph

Mathew²

2005

Journal of Human Ecology

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Consanguinity study was carried out in the Mudugar and Irular tribal groups in the Palakkad district of Kerala. The frequency of inbreeding in them were 78.74 % and 72.20% and mean coefficient of inbreeding 0.05592 and 0.04691 respectively. The prenatal, postnatal and total mortality in the consanguineous groups were 15.84%, 26.23%, and 37.92% in the Mudugars, and 10.96%, 13.05% and 22.59% in the Irulars, which showed significant increase from non consanguineous families. In both the groups, the postnatal figures were in excess than the prenatal. The mortality risk was positively associated with the rate of inbreeding. It is suggested that the observed magnitudes of risk effect in both groups are due to high rates of inbreeding, which produced significantly higher proportions of affected recessive homozygotes with low survival level resulting in fairly wide differentials.

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Inbreeding effect on mortality and morbidity in South Brazilian populations*

Cited by 25 publications

References 17 publications

Biosocial perspective of consanguineous marriages in rural and urban swat, Pakistan

Biosocial perspective of consanguineous marriages in rural and urban swat, Pakistan

Effects of Parental Consanguinity on Fertility, Mortality and Morbidity among the Pattusalis of Tirupati, South India

Effects of Inbreeding in the Mudugar and Irular Tribal Populations in Kerala

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