Incapacity to control emotion in major depression may arise from disrupted white matter integrity and <scp>OFC</scp>‐amygdala inhibition

Zheng, Kaizhong; Wang, Huaning; Liu, Jian; Xi, Yi‐Bin; Li, Liang; Xi, Zhang; Li, Jiaming; Yin, Hong; Tan, Qingrong; Lu, Hongbing; Li, Baojuan

doi:10.1111/cns.12800

Cited by 33 publications

(21 citation statements)

References 41 publications

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“…The UF is an association fiber extending from ventromedial prefrontal (vmPFC) regions to the amygdala, permitting bi-directional communication. Integrity of this tract has been associated with Stroop task performance (He et al, 2016; Schulte et al, 2012); more broadly, it is involved in emotion regulation (d’Arbeloff et al, 2018; Zheng et al, 2018). Disruptions in UF integrity have been linked to mood, anxiety, and trauma-related disorders (Lindner et al, 2018; Jenkins et al, 2016; Koch et al, 2017; Liao et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Fani

King

Clendinen

et al. 2019

Journal of Affective Disorders

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Background: Attentional disruptions are common in PTSD, but findings across neuropsychological and neuroimaging studies have been variable. Few PTSD studies have investigated abnormalities in attention networks using a multi-modal imaging approach and attentional tasks that include emotionally-salient images. This study combined a behavioral task that included these images (emotional Stroop) with functional and structural neuroimaging (fMRI and diffusion tensor imaging; DTI) methods to comprehensively investigate attentional control abnormalities in a highly-traumatized civilian sample. Methods: 48 traumatized women with and without PTSD received clinical assessments, fMRI and DTI. During fMRI, the Affective Stroop (AS), an attentional control task that includes emotionally-salient distractor images (trauma-relevant, positive, neutral) and variable task demands, was administered. Results: In response to more difficult AS trials, participants with PTSD demonstrated lower activation in the dorsal and rostral anterior cingulate cortex and greater activation in the insula. This group also showed comparatively poorer performance on positive AS distractor trials, even after adjusting for trauma exposure. Performance on these trials inversely correlated with structural integrity of the cingulum bundle and uncinate fasciculus. Conclusions: Even after adjusting for trauma exposure, participants with PTSD showed worse performance on an attentional control task in the context of emotional stimuli. They also showed relatively lower cognitive control network activation and greater salience network activation. Fronto-parietal and fronto-limbic white matter connectivity corresponded with AS performance. Our findings indicate that attentional control impairments in PTSD are most evident in the context of emotional cues, and are related to decrements in function and structure of cognitive control and salience networks.

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Section: Discussionmentioning

confidence: 99%

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Fani

King

Clendinen

et al. 2019

Journal of Affective Disorders

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“…Disruption in WM maturation leads to abnormal brain function correlated with numerous neuropsychological disorders . Furthermore, WM injury occurs in various CNS conditions/diseases, such as attention deficit‐hyperactive disorder, autism, multiple sclerosis, Alzheimer's disease, TBI, and stroke .…”

Section: Discussionmentioning

confidence: 99%

Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury

Gao

et al. 2019

CNS Neurosci Ther

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Aims This study determines whether assessment with compound action potentials (CAPs) can distinguish two different forms of cerebral white matter injury at the functional levels. Methods A pure demyelination model was induced in C57/BL6 adult mice by dietary supplementation of cuprizone (0.2%) for 6 weeks. Callosal L‐N5‐(1‐Iminoethyl) ornithine (L‐NIO) hydrochloride (27 mg/mL) was injected into the corpus callosum (CC) to induce a focal white matter stroke (WMS), resulting in both demyelination and axonal injury. White matter integrity was assessed by performing CAP recording, electron microscopy, and immunohistological and luxol fast blue (LFB) staining. Results Immunohistological and electron microscopic analyses confirmed the induction of robust demyelination in CC with cuprizone, and mixed demyelination and axonal damage with L‐NIO. Electrophysiologically, cuprizone‐induced demyelination significantly reduced the amplitude of negative peak 1 (N1), but increased the amplitude of negative peak 2 (N2), of the CAPs compared to the sham controls. However, cuprizone did not affect the axonal conduction velocity. In contrast, the amplitude and area of both N1 and N2 along with N1 axonal conduction velocity were dramatically decreased in L‐NIO‐induced WMS. Conclusions Concertedly, parameters of the CAPs offer a novel functional assessment strategy for cerebral white matter injury in rodent models.

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“…For example, patients with major depressive disorder show dysfunction in the orbitofrontal–AMY (OFC-AMY) structure and effective connectivity in the left hemisphere. 12 Another research study has suggested that depressed type 2 diabetes mellitus patients present decreased AMY FC in the cingulate cortex, the frontal lobe, and the precentral gyrus as well as a decrease in FC in the anterior cingulate cortex associated with the clinical depression score. 13 Similar AMY FC abnormality was also observed in individuals with Parkinson’s disease 14 and end-stage renal disease.…”

Section: Introductionmentioning

confidence: 99%

Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy

Zhao

Liu

et al. 2018

NDT

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PurposeDepressive symptoms are frequent nonmotor symptoms that occur in multiple system atrophy (MSA) patients. However, possible changes that can present in the amygdala (AMY) functional connectivity (FC) of the brain in MSA patients with depressive symptoms (DMSA patients) remain largely unknown.Materials and methodsResting-state functional magnetic resonance imaging scans were obtained from 29 DMSA patients, 28 MSA patients without depression symptoms (NDMSA patients), and 34 healthy controls (HCs). FC was analyzed by defining the bilateral AMY as the seed region. Correlation analysis was performed between the FC and clinical scores.ResultsWhen compared with NDMSA patients, DMSA patients showed increased bilateral AMY FC in the left middle frontal gyrus (MFG) and decreased right AMY FC in the left middle occipital gyrus. Moreover, the AMY FC values in the left middle frontal cortex were positively correlated with the Hamilton Depression Rating Scale-17 item scores. Furthermore, relative to the HCs, DMSA patients presented decreased bilateral AMY FC values in the visuospatial cortex, sensorimotor networks, and limbic areas.ConclusionDepressive symptoms are associated with AMY–MFG FC anomalies in MSA patients. We propose that the middle frontal cortex may play an important role in the neuropathophysiology of depression in MSA patients.

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Incapacity to control emotion in major depression may arise from disrupted white matter integrity and OFC‐amygdala inhibition

Cited by 33 publications

References 41 publications

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Attentional control abnormalities in posttraumatic stress disorder: Functional, behavioral, and structural correlates

Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury

Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy

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