2024
DOI: 10.1038/s42255-024-01164-y
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Inceptor binds to and directs insulin towards lysosomal degradation in β cells

Johanna Siehler,
Sara Bilekova,
Prisca Chapouton
et al.

Abstract: Blunted first-phase insulin secretion and insulin deficiency are indicators of β cell dysfunction and diabetes manifestation. Therefore, insights into molecular mechanisms that regulate insulin homeostasis might provide entry sites to replenish insulin content and restore β cell function. Here, we identify the insulin inhibitory receptor (inceptor; encoded by the gene IIR/ELAPOR1) as an insulin-binding receptor that regulates insulin stores by lysosomal degradation. Using human induced pluripotent stem cell (S… Show more

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