Incidence and anti-microbial resistance profile of Group B Streptococcus (GBS) infection in pregnant women in Nsukka, Enugu State, Nigeria

Ezeonu, Ifeoma M.; Agbo, Martina C.

doi:10.5897/ajmr12.2307

Cited by 20 publications

(26 citation statements)

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“…Except for vancomycin sensitivity, resistance of GBS isolates against penicillin G in the present study is in contrary from a study done in Saudi [ 21 ] where all isolates were sensitive to penicillin G. This high rate of GBS resistance in the current study might be due to differences in laboratory procedures and differences in community awareness in avoiding using non-prescribed Penicillin. The drug susceptibility pattern of GBS isolates to different antimicrobial discs in this study was partly consistent with different studies from abroad [ 18 , 19 , 27 , 28 ] and from Ethiopia [ 8 , 23 – 25 ].…”

Section: Main Textsupporting

confidence: 91%

“…This 12.2% prevalence of maternal GBS colonization in this study is comparatively lower than studies from Hawassa (20.9%) [ 8 ], Italy (17.9%) [ 13 ], the Netherlands (21%) [ 14 ], Tanzania (23%) [ 16 ], China (27.7%) [ 20 ] and Uganda (28.8%) [ 22 ]. But it is higher or comparable with studies from Hong-Kong (10.4%) [ 15 ], Nigeria (11.3, 18%) [ 17 , 18 ], Argentina (7.6%) [ 19 ], Saudi (13.4%) [ 21 ], different districts of Ethiopia (Gondar, Mekelle, Adigrat and Addis Ababa) (9, 13.7, 11.3 and 7.2%) [12, 23, 24 and 25]. This result is definitely higher than studies from Mozambique (1.8%) [ 26 ] and India (2.3%) [ 27 ].…”

Section: Main Textsupporting

confidence: 79%

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Prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women attending antenatal care (ANC) in Nekemte Referral Hospital (NRH), Nekemte, Ethiopia

et al. 2017

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ObjectiveThe main objective of this study was to determine the prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women. The specific objectives include; (1) To determine the prevalence of GBS colonization among pregnant women (2) To determine the drug susceptibility pattern of GBS among pregnant women and (3) To identify associated risk factors with GBS colonization among pregnant women.ResultsThe median age of the participants was 24.5 years (range 16–38) and 86% participants were urban residents. The total prevalence of maternal GBS colonization from vaginal swab culture was 12.2% (22/180). The prevalence of GBS colonization rate was significantly higher in those pregnant women above 37 weeks of gestation [AOR, 95% CI 2.1 (1.2, 11.6), P = 0.03] and married ones [AOR, 95% CI 3.2 (1.8, 11.6), P < 0.021]. Twenty (91%) of GBS isolates were sensitive to vancomycin and the highest resistance was observed against penicillin G (77.3%). The prevalence of GBS colonization in this study was significantly high and differed by gestational age and marital status. None of the GBS isolates were resistant to vancomycin but higher resistance was shown against Penicillin G.

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Section: Main Textsupporting

confidence: 91%

Section: Main Textsupporting

confidence: 79%

Prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women attending antenatal care (ANC) in Nekemte Referral Hospital (NRH), Nekemte, Ethiopia

et al. 2017

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“…This study shows the prevalence of GBS colonization in Sagamu to be 27.7%. This prevalence rate is much higher than that the reported prevalence rates in other Nigerian cities such as Uyo (4%), Maiduguri (9.8%), Ile-Ife (11.3%) and Enugu (18%) [1][2][3][4]. A likely factor that may have contributed to the disparity in the prevalence values is the sample collection site [4,16].…”

Section: Discussionmentioning

confidence: 80%

“…The rate of GBS colonization in the vagina and rectum of pregnant women varies with ethnicity and geographical area. In Nigeria, prevalence values ranging from 4% -18% have been reported [1][2][3][4]. Reports from some other countries have revealed prevalence rates such as 20.9% in Ethiopia [5], 19% in Saudi Arabia [6] and14% in Brazil [7].…”

Section: Introductionmentioning

confidence: 99%

Group B Streptococcus Colonization in Pregnancy: Prevalence, Determinants and Antibacterial Susceptibility Pattern in Sagamu, Nigeria

Akadri¹,

Osuolale²,

Shorunmu³

et al. 2019

JAMMR

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Aims:To establish the prevalence, determinants and the antibiotic susceptibility pattern of Group B streptococcus in pregnant women in Sagamu, Ogun State, Nigeria. Study Design: Prospective cross-sectional study Place and Duration of Study: The study was carried out at the antenatal clinic at Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria, between July 2017 and December 2017. Methodology: The study involved 184 pregnant women attending antenatal clinic. Lower vaginal and rectal swabs were collected under aseptic condition and immediately sent to the laboratory for processing. The samples were assayed for the presence of group B streptococcus using Akadri et al.; JAMMR, 29(10): 1-8, 2019; Article no.JAMMR.49367 2 conventional methods. Information on the socio demographic characteristics and details of delivery were recorded on a data capture sheet. Results: The prevalence of Group B streptococcus was 27.7%. The odds of Group B streptococcus colonization was significantly higher among women of low parity (≤ 2) and binary logistic regression analysis showed that parity was predictive of Group B streptococcus colonization (OR 3.7; 95% CI = 1.03-13.46; P=.045). Younger women (age ≤ 30 years) and women carrying term pregnancies had a non significant trend towards higher odds of Group B streptococcus colonization [(OR= 1.22, 95% CI: 0.6-2.3, P = .54) and (OR=1.6, CI: 0.8-3.2; P = .15) respectively]. The resistance of group B streptococcus isolates to penicillin and ampicillin was 39.2% and 37.3% respectively. Conclusion: The group B streptococcus colonization rate in this study is high. Factors such as low parity, young maternal age and term pregnancies are associated with increased odds of colonization. The emergence of resistance to the commonly prescribed antibiotics calls for reevaluation of the current recommendations regarding the antibiotics prophylaxis. Original Research Article

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“…Primary studies conducted in the East African countries showed the colonization rates ranged from 3.0% to 28.8% [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]; Central Africa,20.0% [27,28]; Western Africa, 2.5% to 34.2% [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48]; Southern Africa, 1.77% to 48.23% [49][50][51][52][53][54][55][56][57]…”

Section: Introductionmentioning

confidence: 99%

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

Gizachew

Tiruneh

Moges

et al. 2019

Ann Clin Microbiol Antimicrob

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Background: Maternal rectovaginal colonization with Streptococcus agalactiae (Group B Streptococcus or GBS) is the most common route for the GBS disease in the perinatal period. The knowledge of maternal colonization, antibiotic resistance and serotype profiles is substantially needed to formulate the broad vaccine. However, it has not been estimated in Africa. This meta-analysis was aimed to determine the pooled prevalence of colonization, antibiotic resistance and serotype profiles of GBS reported in Africa. Methods: Potentially relevant studies from 1989 to 31th January, 2019 were retrieved from the Medline/PubMed, EMBASE, HINARI online databases, periodicals and by requesting authors. Unpublished studies retrieved from grey literature through Google and Google Scholar. Pooled estimates were calculated using the random effect model. Subgroup analysis was done to investigate the burden of colonization across sub-regions, sampling site and countries. Summary estimates were presented using words, Forest plots and Tables. Heterogeneity was assessed using the I 2 statistic. Results: Eighty-three articles were assessed, of which 57 studies conducted in five sub-regions with 21 countries (22,206 pregnant women) met pre-specified inclusion criteria. The overall estimate of recto-vaginal colonization was 19.3% (95% CI 16.9, 21.7). The highest estimate was observed in Southern Africa, 23.8% (95% CI 18.7, 28.9), followed by Northern Africa, 22.7% (95% CI 18.2, 27.2) while the lowest was driven from the Eastern Africa, 15.4% (95% CI 12.1, 18.7). Considerable heterogeneity across and within regions, sampling site, screening methods and countries (I 2 > 75%); and the publication bias were observed (p = 0.031). GBS showed the highest resistance to tetracycline. Resistance to penicillin, amoxicillin, chloramphenicol, ampicillin, ceftriaxone, ciprofloxacin, erythromycin, vancomycin and clindamycin also observed. The V, III, Ia, Ib, and II serotypes altogether were accounted 91.8% in the African studies. Conclusions: The pooled estimate of the maternal colonization with GBS was 19.3% which is equivalent with other many primary and review reports worldwide. The most antibiotic resistance estimate was recorded in the tetracycline followed by penicillin. Five serotypes were the most prevalent in Africa and more data on the antibiotic résistance and serotype distribution patterns are needed from developing countries to devise the effective preventive measures. In addition, the antibiotic susceptibility test methods used in the Africa shall be assessed for its quality.

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Incidence and anti-microbial resistance profile of Group B Streptococcus (GBS) infection in pregnant women in Nsukka, Enugu State, Nigeria

Cited by 20 publications

References 14 publications

Prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women attending antenatal care (ANC) in Nekemte Referral Hospital (NRH), Nekemte, Ethiopia

Prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women attending antenatal care (ANC) in Nekemte Referral Hospital (NRH), Nekemte, Ethiopia

Group B Streptococcus Colonization in Pregnancy: Prevalence, Determinants and Antibacterial Susceptibility Pattern in Sagamu, Nigeria

Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis

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