Incidence and characteristics of urinary tract infections caused byCorynebacterium urealyticum (Corynebacterium group D2)

Nebreda-Mayoral, Teresa; Muñoz‐Bellido, Juan Luis; Garcı́a-Rodrı́guez, J.A.

doi:10.1007/bf01971313

Cited by 32 publications

(35 citation statements)

References 12 publications

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“…About 15 million (>25%) of 57 million annual deaths worldwide are estimated to be related directly to infectious diseases (WHO, 2004). One most interesting aspect of the work of great applied significance is the ability of the medicinal smoke to completely eliminate human pathogenic bacteria Corynebacterium urealyticum causing urinary tract infection (Nebreda-Mayoral et al, 1994), Kocuria rosea causing catheterrelated bacteremia (Altuntas et al, 2004), Staphylococcus lentus causing splenic abscess (Karachalios et al, 2006), Staphylococcus xylosus causing acute polynephritis (Angelina et al, 1982), Tsukamurella inchonensis causing acute myelogenous leukemia (Yassin et al, 1995), Enterobacter aerogenes (Klebsiella mobilis) nosocomial infections (Peres-Bota et al, 2003), Sphingobacterium spiritovorum causing extrinsic allergic alveolitis (Sato and Jiang, 1996) and Sphingomonas sanguinis causing nosocomial non-life-threatening infections (Li et al, 2004) (Table 1). Smoking has some important benefits compared to other drug routes of administration.…”

Section: Resultsmentioning

confidence: 99%

Medicinal smoke reduces airborne bacteria

Nautiyal

Chauhan

Nene

2007

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Medicinal smoke reduces airborne bacteria

Nautiyal

Chauhan

Nene

2007

Journal of Ethnopharmacology

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“…, Nebreda‐Mayoral et al . ). In a previous study, most CU isolates were found to be susceptible to enrofloxacin (Bailiff et al .…”

Section: Discussionmentioning

confidence: 97%

“…In our country, the use of vancomycin and teicoplanin is prohibited for treating veterinary patients, and this might explain the absence of clinical recovery in some of these cases. Tetracyclines and fluoroquinolones have also been used with great success in many patients with CU-UTI (Soriano et al 1990, Nebreda-Mayoral et al 1994. In a previous study, most CU isolates were found to be susceptible to enrofloxacin (Bailiff et al 2005) in dogs and cats.…”

Section: Discussionmentioning

confidence: 99%

Clinical description of Corynebacterium urealyticum urinary tract infections in 11 dogs and 10 cats

Maurey

Boulouis

Canonne-Guibert

et al. 2019

J of Small Animal Practice

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Objectives To examine the clinical signs, laboratory findings, possible predisposing factors, antimicrobial sensitivity and outcomes of dogs and cats diagnosed with urinary tract infection caused by Corynebacterium urealyticum. Materials and Methods Retrospective, observational study of dogs and cats that were diagnosed with urinary tract infection caused by C. urealyticum. Results This report concerns a total of 11 dogs and 10 cats. All cats had a history of urethral catheterisation, and six cats had undergone urological surgery before diagnosis of this specific infection. Dogs had history of neurogenic urinary incontinence (n=5), urethral catheterisation (n=4), urological surgery (n=4), lower urinary tract disease (n=2) or prostatic disease (n=1). In seven animals, previous urine culture was negative. Median urine pH was 8.6 (interquartile range 7.5 to 9), and 19 animals had pyuria and struvite crystalluria. Encrusted cystitis was diagnosed by abdominal ultrasound in nine animals. All but one isolate were resistant to at least three antimicrobial classes. Thirteen isolates were sensitive to tetracyclines. There was bacterial and clinical resolution of the infection in nine dogs and seven cats. Two animals died from sepsis and two cats were euthanased because of clinical deterioration. Clinical Significance Urinary tract infection caused by C. urealyticum should be suspected in animals with pre‐existing urinary disorders, especially if urine is alkaline and there is struvite crystalluria, negative routine urine culture and encrusted cystitis.

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“…Symptoms of UTI in the presence of urine with alkaline pH and struvite crystals are strongly suggestive of infection with C. urealyticum (12). The incidence of UTIs due to C. urealyticum is less than 2% worldwide (13). Treatment of C. urealyticum urinary infection may be difficult.…”

Section: Resultsmentioning

confidence: 99%

Encrusted Cystitis in an Immunocompromised Patient: Possible Coinfection by Corynebacterium Urealyticum and E. Coli

Penta

Fioriti

Chinazzi

et al. 2006

Int J Immunopathol Pharmacol

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Encrusted cystitis is a severe chronic inflammatory disease of the bladder characterized by excessively alkaline urine and calcifications within the bladder wall. A case of a 60 year-old man affected by systemic lupus erythematosus (SLE), which developed encrusted cystitis due to Corynebacterium urealyticum with E. coli coinfection, shows that the treatment of encrusted cystitis with a endoscopic debulking of the encrusted stones and an antimicrobial therapy specific for C. urealyticum often is not sufficient for the complete resolution of symptoms.C. urealyticum is a Gram-positive, slow-growing, multiresistant, urease-positive microorganism with diphtheroid morphology. Since 1985 it has been known as a cause of alkaline encrusted cystitis and other urinary tract infections (1), occurring mainly in patients subjected to urological manipulation. Alkaline encrusted cystitis is a condition characterized by the deposition of inorganic salts on a damaged urothelium. The patient presents symptoms of cystitis (2). Moreover C. urealyticum has been involved in endocarditis, pneumonia, peritonitis, osteomyelitis and soft-tissue infections (3). We report a case of encrusted cystitis due to Corynebacterium urealyticum in a patient with SLE. MATERIALS AND METHODSA 60 year-old man, affected by SLE and in treatment with steroid therapy, presents with persistent symptoms of urinary tract infection including dysuria, pollakiuria, and intermittent hematuria with urinary gravel. He had undergone cystoscopy, which showed stone deposits in the bladder wall. Analysis of the urinary stone deposits on the bladder mucosa revealed the presence of ammonium magnesium phosphate (struvite) and calcium hydroxy phosphate (apatite).The urine sample was plated onto modified MacConkey agar (Oxoid) and CLED (cystine-Iactoseelectrolyte-deficient) agar and incubated at 37°C for 48 h. The identification and the antibiotic sensitivity testing for common pathogen germs were performed with the Phoenyx identification system (Becton Dickinson, USA). The urine and pus culture for Corynebacterium spp. on 7% sheep blood agar (Oxoid, England) was performed with incubation at 37°C in air for 24 h. The microbiological criteria for identification of C. urealyticum were the presence of gram-positive bacteria with diphtheroid morphology catalase-positive and strongly urease-positive. For identification the APICoryne identification strip (API Laboratory' Products; bio-Merieux, France) and the Phoenyx identification system (Becton Dickinson, USA) were utilised. The

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Incidence and characteristics of urinary tract infections caused byCorynebacterium urealyticum (Corynebacterium group D2)

Cited by 32 publications

References 12 publications

Medicinal smoke reduces airborne bacteria

Medicinal smoke reduces airborne bacteria

Clinical description of Corynebacterium urealyticum urinary tract infections in 11 dogs and 10 cats

Encrusted Cystitis in an Immunocompromised Patient: Possible Coinfection by Corynebacterium Urealyticum and E. Coli

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