Incidence and characteristics of young-onset colorectal cancer in the United States: An analysis of SEER data collected from 1988 to 2013

Wang, Weibing; Chen, Wenbin; Lin, Jie; Shen, Qinsong; Zhou, Xile; Lin, Caizhao

doi:10.1016/j.clinre.2018.09.003

Cited by 37 publications

(33 citation statements)

References 23 publications

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“…Traditionally a disease of the elderly, colorectal cancer (CRC) incidence in the young is steadily rising across the globe [1,2]. In contrast, the incidence of CRC in older patients is seeing a progressive decrease in the developed world, which is likely to be attributed to population-based CRC screening [3][4][5]. CRC is the third most common cancer worldwide, with approximately 10% of cases affecting patients aged under 55 years [4,6].…”

Section: Introductionmentioning

confidence: 99%

Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics

et al. 2020

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Background: Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the incidence of inherited cancer syndromes. Methods: A retrospective case note review was conducted for patients aged under 55 years who were diagnosed with CRC between 2005 and 2015 in the North East of Scotland. Cases were identified by pathology records and data was obtained from patient notes. Analysis was performed using SPSS version 25 (IBM, New York, USA) to produce Kaplan-Meier survival estimates, descriptive statistics and markers predictive for genetic referral.Results: Data from 345 patients (age range 22-54 years) were identified. The one year, five year and overall survival rates were found to be 89, 63 and 55%, respectively. Most patients (61%) presented with advanced disease. Of 201 patients that met criteria for genetic referral, only 93 (46%) were referred to genetic services. Microsatellite instability (MSI) was identified in 14% of those referred. Conclusion: Survival in yCRC was found to be better than that in later onset disease, despite higher rates of advanced disease. Patients were under-referred to genetic services, where a significant proportion were found to be MSI positive and investigated for Lynch syndrome.

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Section: Introductionmentioning

confidence: 99%

Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics

et al. 2020

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“… 4 Conversely, some studies reported that CRC in young adults was more aggressive and resulted in worse survival, perhaps because they had more mucinous and signet ring cell histology, had a family history of CRC and were less likely to be screened. 6 In addition, we found that while the incidence of CRC in Europe was also increasing in young adults, the rate of increase in the USA was significantly higher than that in Europe ( figure 1A–C ). This may be because the USA has a significantly higher incidence of obesity than Europe.…”

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confidence: 72%

“…We know little about the indications for colonoscopy in young adults, but studies have shown increases in colonoscopy use that parallel the incidence of CRC in young adults, which could explain the increasing rates of local or regional disease 4. Conversely, some studies reported that CRC in young adults was more aggressive and resulted in worse survival, perhaps because they had more mucinous and signet ring cell histology, had a family history of CRC and were less likely to be screened 6. In addition, we found that while the incidence of CRC in Europe was also increasing in young adults, the rate of increase in the USA was significantly higher than that in Europe (figure 1A–C).…”

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confidence: 99%

Comparison of the incidence of colorectal cancer in young adults between the USA and Europe

Wei

Luo

Zhang

et al. 2019

Gut

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“…Traditionally a disease of the elderly, colorectal cancer (CRC) incidence in the young is steadily rising across the globe (1,2). In contrast, the incidence of CRC in older patients is seeing a progressive decrease in the developed world, which is likely to be attributed to population-based CRC screening (3)(4)(5). CRC is the third most common cancer worldwide, with approximately 10% of cases affecting patients aged under 55 years (4,6).…”

Section: Introductionmentioning

confidence: 99%

Young-Onset Colorectal Cancer in the North East of Scotland: Survival, Clinico-Pathological Features and Genetics

Perrott

Laurie

Laws

et al. 2020

Preprint

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Background Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the incidence of inherited cancer syndromes. Methods A retrospective case note review was conducted for patients aged under 55 years who were diagnosed with CRC between 2005-2015 in the North East of Scotland. Cases were identified by pathology records and data was obtained from patient notes then crosschecked with the NHS Grampian genetics electronic case records. Analysis was performed using SPSS version 25 (IBM, New York, USA) to produce Kaplan-Meier survival estimates, descriptive statistics and markers predictive for genetic referral. Results Data from 345 patients (age range 22-54 years) were identified. The one year, five year and overall survival rates were found to be 89%, 63% and 55%, respectively. Most patients (61%) presented with advanced disease. Of 201 patients that met criteria for genetic referral, only 93 (46%) were referred to genetics services. Microsatellites instability (MSI) was identified in 14% of those referred. Conclusions Survival in yCRC was found to be better than that in later onset disease, despite higher rates of advanced disease. Patients were under-referred to genetic services, where a significant proportion were found to be MSI positive and investigated for Lynch syndrome.

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Incidence and characteristics of young-onset colorectal cancer in the United States: An analysis of SEER data collected from 1988 to 2013

Cited by 37 publications

References 23 publications

Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics

Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics

Comparison of the incidence of colorectal cancer in young adults between the USA and Europe

Young-Onset Colorectal Cancer in the North East of Scotland: Survival, Clinico-Pathological Features and Genetics

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