Incidence and Clinical Behavior of Papillary Thyroid Carcinoma in Renal Allograft Recipients: A Single Center Experience

Is Thyroid Cancer Recurrence Risk Increased After Transplantation?

“…The study was retrospective and a selection bias cannot be excluded. This distribution is, however, in accordance with two previous studies showing that thyroid cancer following transplantation had frequent lymph node involvement (17,18) and an altered gender distribution with an overrepresentation of male patients.…”

“…It is also worth noting that only one patient with an incidentally discovered thyroid cancer had persistent disease. Similar findings were reported in a recent study investigating thyroid cancer behavior after transplantation (18). Accordingly, favorable prognosis of incidental carcinomas has been reported in the general thyroid cancer population (39).…”

“…Previously, the outcomes of only 12 patients were investigated retrospectively (18). Thus, to our knowledge, the present work is the first report on the outcome of thyroid cancer in a large cohort of transplant recipients.…”

“…In a recent meta-analysis including 50 861 patients, the standardized incidence ratio for thyroid cancer was 6.9-fold higher in transplanted patients than in the nontransplanted group; thus, thyroid cancer diagnosis could be considered a serious risk after solid organ transplantation (16). However, diagnosis of thyroid cancer is closely related to screening procedures and only a few studies have addressed the question of thyroid carcinoma patient outcomes after transplantation (17,18). Furthermore, such studies have only included data from kidney transplant recipients, whose thyroid cancer was diagnosed after transplantation.…”

Thyroid nodule and thyroid cancer management pre- and post-cardiac transplantation

“…36 This population may also have more aggressive thyroid cancer with lymph node metastasis, especially to the lateral neck compartment and mediastinum. 37 In renal recipients, the median time to diagnosis of thyroid cancer occurs significantly earlier than in other cancers (68 vs 102 months), raising the possibility of differing oncogenic pathways. 27 However, additional studies are needed before suggesting that periodic ultrasound imaging be used for thyroid cancer surveillance in transplant recipients.…”