Incidence and Clinical Characteristics of Ocular Involvement in Mucous Membrane Pemphigoid

Hong, Gloria; Khan, Irfan; Shifera, Amde Selassie; Okeagu, Chinwenwa; Thorne, Jennifer E.

doi:10.1080/09273948.2018.1455879

Cited by 14 publications

(16 citation statements)

References 15 publications

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“… 14 , 15 In 2014, the calculated prevalence of MMP in Germany was 25 cases/million inhabitants, with a female predominance of 30.52/million, versus 18.37/million. 13 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 No geographic or racial predilection has been described.…”

Section: Clinical Presentationmentioning

confidence: 99%

“… 42 An average female proportion of 52% (range 37–81%) has been observed. 14 , 17 , 18 , 22 , 36 , 37 , 38 , 39 , 40 , 41 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 The mean duration of symptoms prior to diagnosis of ocular MMP ranges from 225 days to 6.4 years. 14 , 36 , 39 , 52 Mehra et al .…”

Section: Clinical Presentationmentioning

confidence: 99%

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European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology – Part I

Rashid

Lamberts

Borradori

et al. 2021

Acad Dermatol Venereol

103

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This guideline on mucous membrane pemphigoid (MMP) has been elaborated by the Task Force for Autoimmune Blistering Diseases of the European Academy of Dermatology and Venereology (EADV) with a contribution of physicians from all relevant disciplines and patient organizations. It is a S3 consensus-based guideline encompassing a systematic review of the literature until June 2019 in the MEDLINE and EMBASE databases. This first part covers methodology, the clinical definition of MMP, epidemiology, MMP subtypes, immunopathological characteristics, disease assessment and outcome scores. MMP describes a group of autoimmune skin and mucous membrane blistering diseases, characterized † Both authors contributed equally.

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology – Part I

Rashid

Lamberts

Borradori

et al. 2021

Acad Dermatol Venereol

103

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“…In PV, cutaneous lesions are widespread but mucosal lesions may occur first [72]. MMP may involve ocular mucosa and lead to scarring [73]. Most MMP patients are middle aged women whereas a roughly equal gender distribution is seen in PV [72,74].…”

Section: Vesiculobullous Lesionsmentioning

confidence: 99%

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review

Fitzpatrick

Cohen

Clark

2019

Head and Neck Pathol

141

103

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Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Biopsy may be indicated in many ulcerative lesions of the oral cavity although some are more suitable for clinical diagnosis. Neoplastic ulcerated lesions are notorious in the oral cavity for their ability to mimic benign ulcerative lesions, highlighting the essential nature of biopsy to establish a diagnosis in cases that are not clinically identifiable or do not respond as expected to treatment. Adjunctive tests may be required for final diagnosis of some ulcerated lesions especially autoimmune lesions. Laboratory tests or evaluation to rule out systemic disease may be also required for recurrent or severe ulcerations especially when accompanied by other symptoms. This discussion will describe the clinical and histopathologic characteristics of a variety of ulcerated lesions found in the oral cavity. KeywordsOral ulcer • Herpetic gingivostomatitis • Aphthous stomatitis • Oral erythema multiforme • Oral medication related ulcer • Oral lichen planus • Oral vesiculobullous lesions • Traumatic oral ulcer • Oral squamous cell carcinoma • Oral lymphoma

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“…1,5,6 Large, retrospective case studies on MMP are scarce and have been mainly conducted in patients with oral or ocular involvement. 7,8 The aim of this study was to describe clinical and diagnostic findings as well as treatment responses in patients diagnosed with different subtypes of MMP to support early recognition and improve patient care.…”

Section: Introductionmentioning

confidence: 99%

Insights into clinical and diagnostic findings as well as treatment responses in patients with mucous membrane pemphigoid: A retrospective cohort study

Rashid¹,

Meijer²,

Bolling³

et al. 2022

Journal of the American Academy of Dermatology

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Incidence and Clinical Characteristics of Ocular Involvement in Mucous Membrane Pemphigoid

Abstract: Patients presenting with extraocular MMP are at risk for developing ocular MMP, and all MMP patients are at risk for developing secondary extraocular MMP locations, although the rates were low.

Cited by 14 publications

References 15 publications

European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology – Part I

European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology – Part I

Ulcerated Lesions of the Oral Mucosa: Clinical and Histologic Review

Insights into clinical and diagnostic findings as well as treatment responses in patients with mucous membrane pemphigoid: A retrospective cohort study

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