Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany

Abstract

Purpose The aim of this project was to provide an overview of the epidemiology of primary salivary gland carcinomas (SGC) in terms of incidence, distribution of clinicopathological features and survival in one of the largest cancer registries in Europe. Methods Data were collected from patients with SGC of the major salivary glands registered in the population-based state cancer registry (Landeskrebsregister LKR) in North Rhine-Westphalia (NRW), Germany from 01/01/2009 to 12/31/2018. Age standardization of incidence was performed and relative survival estimates were computed by sex, histological group, age group and T-, N-, and M-stage. Results A total of 1680 patients were included in this analysis. The most frequent tumor localization was the parotid gland (78%). Adenocarcinoma (not otherwise specified) was the most common tumor entity (18.5%). Most tumors were found in stages T1–T3 (29% T1; 29% T2; 28% T3). The age-standardized incidence rate (ASR) for SGC was 0.65/100,000 and remained stable during the observation period. There was an age-dependent incidence increasing especially from the age 70 years and onwards. The overall 5-year relative survival (RS) for all patients with SGC was 69.2%. RS was 80–95.6% for T1–2 stage tumors, 60.3% for T3, 47.3% for T4 stage, 87.4% for N0 and 51.2% for N1–2, 74.4% for M0 and 44.9% for M1. Conclusion Age-standardized incidence for SGC has been stable for the observed 10-year period. Smaller tumors and those without lymph node or distant metastases had a better RS than more advanced tumors.

Major and minor salivary gland cancers: A multicenter retrospective study

“…Two‐hundred and fifty (56.4%) of 443 patients were male. Although the ratio of women to men is higher in favor of women in some studies, there are also studies with similar results to ours 4–7 …”

“…8,9 In another study the most frequently diagnosed histological type is adenocarcinoma not otherwise specified (18.5%). 5 In our study, the most common histologic types in the major salivary glands were AdCC 95 (37.8%), followed by MEC 46 (18.3%).…”

“…In the study of Benchetrit et al and in another German population‐based state cancer registry the most common histological type is MEC (29.8% and 20.8%, respectively) 8,9 . In another study the most frequently diagnosed histological type is adenocarcinoma not otherwise specified (18.5%) 5 . In our study, the most common histologic types in the major salivary glands were AdCC 95 (37.8%), followed by MEC 46 (18.3%).…”

“…Although the ratio of women to men is higher in favor of women in some studies, there are also studies with similar results to ours. [4][5][6][7] Malignant tumors in the major salivary glands are extremely rare. In different studies, there were different results for most histologic types seen in major SGCs.…”

An Unusual Case of Metachronous Tumors of Prostate and Parotid Gland: A Diagnostic Dilemma

“…SDC usually presents as an aggressive neoplasm, forming a bulky mass with frequent extraglandular extension and regional spread [6]. Most SDCs originate from the major salivary glands, the parotid gland being the most common site (84.7%); some tumors in the minor salivary glands, sinonasal tract, and lacrimal gland have also been reported [7,8].…”