Incidence and Clinical Significance of False-Negative Sextant Prostate Biopsies

Rabbani, Farhang; Stroumbakis, Nicholas; Kava, Bruce R.; Cookson, Michael S.; Fair, William R.

doi:10.1097/00005392-199804000-00047

Cited by 68 publications

(87 citation statements)

References 11 publications

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“…The above point is more striking when compared with men for whom TTMB was used after two or more earlier negative biopsies (Figure 2c). In these men, the cancer detection rate remained high (38%), but the only areas in which cancer was frequently identified were the anterior-most aspects of the gland (regions 1,8,7,9,17,18,19,24). Presumably, with a large enough number of transrectal cores taken (mean of 37.9 prior cores in men with 3 prior biopsies), cancer closer to the rectum is fairly readily discovered.…”

Section: Discussionmentioning

confidence: 97%

“…For each biopsy core, the template coordinate and the offset from base were recorded. Biopsy regions included posterior prostate (3,4,12,13,21,22), posterior lateral (2,5,11,14,20,23), anterior lateral (1,6,9,10,15,16), anterior apex (19,24), and TZ (7,8,17,18) After completion of all sampling, patients underwent cystoscopic evaluation.…”

Section: Methodsmentioning

confidence: 99%

“…Nonetheless, a significant minority of men with an initial negative biopsy are found to have prostate cancer on subsequent biopsies. 1,2 In addition, initial biopsy pathology frequently underestimates the Gleason score that would be assigned based on full gland evaluation. 3 In an effort to reduce false-negative rates and improve accuracy of staging, investigators have explored alternative biopsy approaches, including increasing the number of cores sampled and changing access with a transperineal approach.…”

Section: Introductionmentioning

confidence: 99%

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Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Taira

Merrick

Galbreath

et al. 2009

Prostate Cancer Prostatic Dis

262

171

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Transrectal ultrasound (TRUS) biopsy can miss 20-30% of clinically significant cancers. We evaluate an alternative approach-transperineal template-guided mapping biopsy (TTMB) in the initial and repeat biopsy setting. From January 2005 through September 2008, 373 consecutive men underwent TTMB (294 men with X1 prior negative biopsy and 79 men as the initial biopsy). The location of each positive biopsy core, number of positive cores, and percent involvement of each core was recorded. Cancer detection rate for the initial biopsy was 75.9%. For men with 1, 2, and X3 prior negative biopsies detection rates were 55.5%, 41.7%, and 34.4%, respectively. In all, 55.5% of the cancers identified were Gleason X7. The majority of the cancers were multifocal. There was no significant change in the number of positive cores or Gleason score as the number of prior biopsies increased. The anterior and apical aspects of the prostate were among the most common cancer locations. TTMB provides a high rate of cancer detection as initial and repeat biopsy. TTMB was particularly effective at diagnosing anterior and apical cancer. TTMB may have particular application for men considering active surveillance, with prior negative TRUS biopsies, and those considering subtotal gland or other minimally invasive treatments.

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Taira

Merrick

Galbreath

et al. 2009

Prostate Cancer Prostatic Dis

262

171

View full text Add to dashboard Cite

show abstract

“…[9][10][11] Recently, the average number of biopsies has been gradually increasing, however, the detection rate remains unchanged and the need of repeat biopsy is increasing. Despite the high rate of false negative biopsy findings (20-30%), as reported by Rabbani et al 12 and Fleshner and al. 13 , sextant biopsies are still in wide use.…”

Section: Introductionmentioning

confidence: 83%

The Incidence of Hyperechoic Prostate Cancer in Transrectal Ultrasound–Guided Biopsy Specimens

Spajić¹,

Eupic

Tomas

et al. 2007

Urology

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“…Studies have shown that in more than 20% of cancers, at least two biopsy sessions were required to diagnose the tumor, and it is not yet clear how many samples (per session) are necessary to reach a diagnosis. Although increasing the number of random TRUS biopsy samples yields a marginal improvement in detection rate [16,9,18], only a very small fraction of the gland is sampled with even a dozen needle placements. Thus, it is unlikely that simply increasing the number of samples taken will solve the problem.…”

Section: Introductionmentioning

confidence: 99%

Landmark-Guided Surface Matching and Volumetric Warping for Improved Prostate Biopsy Targeting and Guidance

Haker

Warfield

Tempany

2004

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2004

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Abstract. We present a composite method for landmark-guided surface matching and volumetric non-rigid registration, with an application to prostate biopsy. The two-step method, based primarily on finite element and thin-plate spline techniques, consists of a boundary matching process, followed by a volumetric warping step. In practice, the boundary matching method allows for registration of anatomical surfaces, such as prostate gland capsules, in a way that is bijective, i.e. one-to-one and onto. The novelty of this approach is that it allows for the exact matching of pre-specified corresponding landmark points on the two surfaces to be matched. The second step, volumetric warping, is presented as an extension of our previous work in prostate registration, having been improved to address the problem of non-bijectivity (the "flipping" of tetrahedra) which can result from the linear-elastic modelling of the deformation. We discuss the use of our method for the registration of pre-operative magnetic resonance (MR) imaging for improved targeting and visualization during MR-guided prostate biopsy. Although presented within the context of prostate MR image registration, our composite surface matching and volumetric registration method has general applicability to other organs and imaging modalities such as CT and ultrasound.

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Incidence and Clinical Significance of False-Negative Sextant Prostate Biopsies

Abstract: Our findings suggest that this 23% incidence of false-negative biopsies represents significant cancer. This relatively high incidence is important to consider in treatment modalities in which prostate biopsy may be performed to determine response to therapy.

Cited by 68 publications

References 11 publications

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting

The Incidence of Hyperechoic Prostate Cancer in Transrectal Ultrasound–Guided Biopsy Specimens

Landmark-Guided Surface Matching and Volumetric Warping for Improved Prostate Biopsy Targeting and Guidance

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