Incidence and clinicopathological features of meningioma

Abstract

The incidence of intracranial meningioma in Manitoba, Canada, was reviewed from 1980 through 1987. During that time, 193 tumors were diagnosed, with a male:female ratio of 1:2. This occurrence corresponded to crude incidence rates of 2.3/100,000 for all meningiomas and 0.17/100,000 for malignant meningiomas. Among malignant meningiomas, the male:female ratio was 1:1. The age-specific annual incidence rate increased with age up to the eighth decade where it peaked at 8.4/100,000. The distribution of histopathological subtypes was: 74 meningotheliomatous (38%), 64 transitional (33%), 14 malignant (7%), 14 fibroblastic (7%), seven psammomatous (4%), four angioblastic (2%), and 16 unknown (8%). The diagnosis of malignant meningioma was based on the World Health Organization criteria, with only Grade III and IV tumors included in this subtype. Clinical features did not allow for differentiation of benign from malignant neoplasms. Individuals with malignant tumors were, however, more likely to suffer paresis (50%) and less likely to be without deficit (14%) than their benign counterparts. The radiographic appearance of "mushrooming" was observed only in patients with malignant meningioma. All malignant tumors showed evidence of peritumoral edema; however, none exhibited calcification. During the 8-year study interval, the tumor recurred in 10 (71%) of the 14 patients with malignant meningioma. Tumor recurrence was accompanied by dedifferentiation from a more benign histology in four patients (2% of the total material).

Descriptive Epidemiology of World Health Organization Grades II and III Intracranial Meningiomas in the United States

“…One older study from 1989 reported a crude incidence rate of malignant meningiomas of 0.17 per 100 000 in Manitoba, Canada, which was lower than that found in our study. 9 Our study demonstrates that the incidence of WHO II meningiomas is increasing, while the incidence of WHO III meningiomas is decreasing. No prior studies have evaluated temporal trends in WHO II and III meningiomas for comparison.…”

“…6,8,9 When stratified by age, females had the highest incidence rate ratios for meningiomas of all WHO grades during middle ages (35 -64 y), Kshettry et al: Epidemiology of high-grade meningiomas whereas males had a higher incidence in older ages (≥75 y). An increase in risk excess in middle-aged women has been demonstrated with WHO I meningiomas in prior studies as well.…”

“…Prior studies have demonstrated an increased risk of higher grade meningiomas in the convexity location. 5,8,9,36,37 Fifth, the current study is limited to the population of the United States, which limits the ability to generalize the results to other countries that may have significantly different genetic and environmental factors. Sixth, we must acknowledge limitations in the collection of race and ethnicity data.…”

Meningiomas supratentoriais: diagnóstico, resultados cirúrgicos e complicações

“…Todavia, faltam evidências definitivas que esclareçam o verdadeiro papel de todos estes fatores na gênese dos meningiomas. Sua incidência é de 2:100000 23 . Em grandes séries compreendem aproximadamente 20% de tumores intracranianos operados 10 .…”

Musical Hallucination in a Patient With Frontal Lobe Meningioma

“…The clinical symptoms usually depend on the involved anatomic site, but many of them are found incidentally. The three most common symptoms are headaches, mental status changes, and paresis (8). Aggression and hallucination are seen in association with a basal frontal lesion and may mimic psychotic syndromes like hypomania and schizophrenia, particularly if the tumor encroaches on the third ventricle and adjacent structures (1,2).…”