Incidence and Cognitive Decline of Alzheimer’s Disease and Other Dementia by Apolipoprotein ε4 Allele Presence: A Community-Based Cohort Study in Korean Elderly

Abstract

The association between ε4 allele and AD prevalence is also reported in Korea. 6 This relation was also observed with AD patients older than 100 years. 7 Besides developing AD, the correlation of APOE ε4 with the rate of cognitive impairment, deterioration of function, and premature death have been reported in many studies. [8][9][10] Education and sex among the factors impacting on faster cognitive decline are considered to be associated with carriage of the APOE ε4 allele although the results are mixed still. 11-13 Ethoregional differences were observed also in the relationship between education and cognitive decline. [14][15][16] We aimed to investigate the effect of the APOE ε4 allele as longitudinal and lifetime risk of AD or other dementia and to investigate the relationship between education, sex and cognitive decline according to the APOE ε4 allele in risk across the Korean-community population.