Incidence and consequences of varicella in children treated for cancer in Guatemala

Brown, Amy; Asturias, Edwin J.; Melgar, Mario; Antillón‐Klussmann, Federico; Mettler, Pamela; Levin, Myron J.

doi:10.1007/s12519-016-0025-y

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…VZV mortality on the other hand, was due to disseminated infection and multi-organ failure. Comparable to our VZV mortality of 5%, a study published by Brown et al in 2016 reported 13.6% of pediatric cancer patients with VZV infections required critical care and 3.4% died due to disseminated infection [27]. Although studies have linked lymphopenia to increased mortality in VZV [28], none of the lymphopenic participants in our cohort with VZV infection developed any complications.…”

Section: Herpesviruses Infectionssupporting

confidence: 57%

Epidemiology and clinical characteristics of viral infections in hospitalized children and adolescents with cancer in Lebanon

et al. 2020

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Background Viral infections in children and adolescents with malignancy are commonly encountered and have a significant impact on morbidity and mortality. Studies and epidemiological data regarding viral infections in children with cancer in developing countries are lacking. This retrospective cohort study aims to assess the burden of viral infections in children and adolescents with cancer, by assessing prevalence, risk factors, as well as morbidity and mortality of common viruses over a period of 8 years. Methods and findings Medical records of cancer patients treated at the Children Cancer Center of Lebanon were reviewed and 155 participants under the age of 21 were identified with at least one documented viral infection during the period from July 2009 to November 2017. This subset included 136 participants with active malignancy and 19 participants with a history of cancer who underwent hematopoietic stem cell transplantation [HSCT] and were in remission; the latter group was analyzed separately. Information regarding participant characteristics, hospital course, and complications were obtained. Associations between viral infections and certain factors were assessed. In the cohort, 64% were male, 81% were Lebanese. In participants with active malignancy, 90% received chemotherapy in the 6 months preceding the viral infection episode, 11% received radiotherapy. 51% of participants were neutropenic at the time of viral detection, and 77% were lymphopenic. 17% experienced a bacterial coinfection, and 3 experienced a viral co-infection. Among 162 viral infection episodes,

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Section: Herpesviruses Infectionssupporting

confidence: 57%

Epidemiology and clinical characteristics of viral infections in hospitalized children and adolescents with cancer in Lebanon

et al. 2020

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“…18 Common diseases of childhood, like chicken pox, incur a serious morbidity and mortality risk for children undergoing cancer therapy. 19 CNS manifestations of viral infections, such as varicella zoster, herpes simplex and measles, can be protean and overlapping, making clinical diagnoses difficult. [20][21][22] Measles infections are particularly concerning because of its diverse CNS manifestations in immunocompromised hosts, such as acute measles encephalitis, subacute measles inclusion-body encephalitis, epilepsia partialis continua, and subacute sclerotic panencephalitis.…”

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confidence: 99%