Incidence and diagnosis of unilateral arterial cerebral infarction in newborn infants

Schulzke, Sven; Weber, Peter; Luetschg, Juerg; Fahnenstich, Hubert

doi:10.1515/jpm.2005.032

Cited by 87 publications

(46 citation statements)

References 12 publications

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“…The reported incidence of NAIS differs widely between studies, possibly because of differences in inclusion criteria, reporting strategies, study duration, frequency of diagnostic procedures in at-risk children, study populations (eg, including or excluding preterm neonates), and health care policies (see Table 1). Epidemiologic data have been provided by 4 hospital-based studies 13,[16][17][18] Hospital-based studies report a higher incidence of NAIS than do population-based studies. 13,[16][17][18] Three of the population-based studies included NAIS (presentation during the neonatal period) and PPIS (diagnosed retrospectively).…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiologic data have been provided by 4 hospital-based studies 13,[16][17][18] Hospital-based studies report a higher incidence of NAIS than do population-based studies. 13,[16][17][18] Three of the population-based studies included NAIS (presentation during the neonatal period) and PPIS (diagnosed retrospectively). 2,12,14 Two population-based studies included only NAIS.…”

Section: Discussionmentioning

confidence: 99%

“…Hospital-and population-based studies in North America and Europe have provided epidemiologic data suggesting that the incidence of ischemic perinatal stroke is between 5 and 43 per 100 000 live births. 2,[10][11][12][13][14][15][16][17][18] Studies have shown that about half of patients become symptomatic during the neonatal period. 14 A summary of epidemiologic studies on NAIS and PPIS is presented in Table 1.…”

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Incidence and Outcomes of Symptomatic Neonatal Arterial Ischemic Stroke

et al. 2015

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BACKGROUND AND OBJECTIVES: Neonatal arterial ischemic stroke (NAIS) is associated with considerable lifetime burdens such as cerebral palsy, epilepsy, and cognitive impairment. Prospective epidemiologic studies that include outcome assessments are scarce. This study aimed to provide information on the epidemiology, clinical manifestations, infarct characteristics, associated clinical variables, treatment strategies, and outcomes of NAIS in a prospective, population-based cohort of Swiss children. RESULTS: One hundred neonates (67 boys) had a diagnosis of NAIS. The NAIS incidence in Switzerland during this time was 13 (95% confidence interval [CI], 11-17) per 100 000 live births. Seizures were the most common symptom (95%). Eighty-one percent had unilateral (80% left-sided) and 19% had bilateral lesions. Risk factors included maternal risk conditions (32%), birth complications (68%), and neonatal comorbidities (54%). Antithrombotic and antiplatelet therapy use was low (17%). No serious side effects were reported. Two years after birth, 39% were diagnosed with cerebral palsy and 31% had delayed mental performance.CONCLUSIONS: NAIS in Switzerland shows a similar incidence as other population-based studies. About one-third of patients developed cerebral palsy or showed delayed mental performance 2 years after birth, and children with normal mental performance may still develop deficits later in life. WHAT'S KNOWN ON THIS SUBJECT:Neonatal arterial ischemic stroke is associated with later cerebral palsy and cognitive impairment. Many studies on neonatal ischemic stroke are limited by modest sample sizes, and prospective studies that include outcomes assessments are scarce. WHAT THIS STUDY ADDS:Results from this prospective, nationwide, population-based study provide information on the epidemiology, associated clinical variables, clinical manifestation, vascular distribution, and treatment of neonatal arterial ischemic stroke. The study also provides outcomes regarding motor function and cognition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Incidence and Outcomes of Symptomatic Neonatal Arterial Ischemic Stroke

et al. 2015

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“…3 The incidence of perinatal stroke has been estimated at 1 every 1600-4000 live newborn infants; 80% are of ischemic nature and, even though it is difficult to know the actual incidence of ischemic cases, it is probably higher than 1 every 1500 live newborn infants, making the perinatal period one of the moments in life with the highest risk for stroke. 1,[4][5][6] Such high incidence of perinatal stroke is because both the mother and the fetus have transient risk factors, which are typical of late stages of pregnancy, childbirth and the first postnatal weeks, when the newborn infant is prone to a prothrombotic state ( Table 1). Due to this transient predisposition, the risk of recurrence is very low, between 2% and 3%.…”

Section: Clinical Manifestations and Diagnosis Of Perinatal Strokementioning

confidence: 99%

Presumed perinatal ischemic stroke. A review

2015

Arch Argent Pediat

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The risk of stroke is actually highest during the perinatal period. However, some newborn infants may have no signs indicative of the need of brain imaging, or brain images taken may not be sensitive enough to diagnose ischemic injuries; so, the diagnosis of stroke may be delayed several months or years. The neurological picture in patients with perinatal stroke detected through neuroimaging months or years after the neonatal period is called presumed perinatal ischemic stroke. Although a presumed perinatal ischemic stroke is just a confirmation of the existence of an important level of underdiagnosis in relation to perinatal stroke, establishing the extent of this condition has allowed to improve knowledge on perinatal ischemic vascular disease.

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“…[1][2][3] La principal manifestación clínica de esta entidad son las convulsiones; sin embargo, muchos recién nacidos que sufrieron un ACV prenatal o neonatal no manifestarán signos sugerentes y, en consecuencia, el ACV se diagnosticará tiempo después, debido a sus secuelas y no a la sintomatología aguda. Para esta situación en la cual el diagnóstico de ACV perinatal se difiere meses o años y se realiza fuera del período neonatal, se ha adoptado la expresión accidente cerebrovascular isquémico presuntamente perinatal (Presumed Perinatal Ischemic Stroke; PPIS, por sus siglas en inglés).…”

Section: Introductionunclassified

Preferencia manual precoz: signo de alarma de accidente cerebrovascular perinatal. Serie de casos

Gacio

2016

Arch Argent Pediat

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Arch Argent Pediatr 2016;114(5):e374-e377 / e374Presentación de casos clínicos RESUMEN Accidente cerebrovascular presuntamente perinatal es la expresión utilizada para los casos en los que se diagnostica un accidente cerebrovascular antiguo por sus secuelas y no por la sintomatología aguda. Muchos accidentes cerebrovasculares presuntamente perinatales tienen como primera manifestación una hemiparesia congénita, la cual se hace notoria entre el cuarto y el octavo mes de vida como preferencia manual precoz. Es por esto por lo que la preferencia manual clara y persistente desarrollada antes del año de vida debe asumirse como un signo de alarma de una probable secuela motora. En este trabajo, revisamos la historia clínica de 15 casos de accidente cerebrovascular presuntamente perinatal para evaluar la edad en la que la consulta derivó en el diagnóstico, el motivo de consulta y la edad de desarrollo de la preferencia manual. Palabras clave: accidente cerebrovascular presuntamente perinatal, hemiparesia congénita, lateralidad funcional. ABSTRACTPresumed perinatal ischemic stroke is the term used for cases in which an old stroke is diagnosed by the consequences of it and not by the acute symptoms. Many presumed perinatal ischemic strokes have congenital hemiparesis as the first manifestation, which is usually noticed between the fourth and eighth month of life as early hand preference. That is why the clear and persistent handedness developed before one year of age must be assumed as a warning sign of probable motor sequelae. In this paper we review the medical records of 15 cases of presumed perinatal ischemic stroke to assess the age at which the consultation led to the diagnosis, reason for consultation and age at development of handedness.

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Incidence and diagnosis of unilateral arterial cerebral infarction in newborn infants

Cited by 87 publications

References 12 publications

Incidence and Outcomes of Symptomatic Neonatal Arterial Ischemic Stroke

Incidence and Outcomes of Symptomatic Neonatal Arterial Ischemic Stroke

Presumed perinatal ischemic stroke. A review

Preferencia manual precoz: signo de alarma de accidente cerebrovascular perinatal. Serie de casos

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