Incidence and disease burden of herpes zoster in the population aged ≥50 years in China: Data from an integrated health care network

Sun, Xiaohui; Zheng, Wei; Lin, Hongbo; Jit, Mark; Li, Zhenwei; Fu, Chuanxi

doi:10.1016/j.jinf.2020.12.013

Cited by 53 publications

(59 citation statements)

References 53 publications

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“…This may be due to a lack of confidence in antivirals and delayed treatment. The population of outpatients receiving oral antivirals in the US was also near 64%, (22) which is similar to the percentage of Chinese patients receiving antivirals (10). Oral antiviral medications were found to be effective in reducing the duration of acute neuritis symptoms and the risk of complications.…”

Section: Discussionmentioning

confidence: 89%

“…Data on trends in the incidence rate of herpes zoster in China are limited. A recent study reported that the overall incidence of herpes zoster in the population aged over 50 years in China was 6.64 per 1000 person-years (10). Another possible reason for the increased prescription of antivirals could be the increasing demand for better management of herpes zoster in China.…”

Section: Discussionmentioning

confidence: 99%

“…Herpes zoster and its complications have been reported to cause approximately 67,000 quality-adjusted life years (QALYs) and incur costs of $2.4 billion in direct medical costs and productivity losses annually in the US (6). Economic studies in other countries and in China have also revealed that herpes zoster was associated with impaired quality of life and substantial health care resource use (7)(8)(9)(10). Thus, attention should be paid to the management of herps zoster.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral treatment in outpatients with herps zoster in six major areas of China, 2010–2019

Zhao

Jin

et al. 2022

Front. Public Health

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ObjectiveThe objective of this study was to assess the status and trends of antiviral treatment in outpatients with herpes zoster in China.MethodsPrescription data on antiviral drugs were extracted from the database of the Hospital Prescription Analysis Program of China according to the inclusion criteria. Yearly prescriptions and costs were calculated, and trends were analyzed. The trends were further stratified by age, sex, and specific drug use. The distribution of defined daily costs (DDCs) of valaciclovir and famciclovir were analyzed, and trends in the median DDCs were identified.ResultsA total of 132,911 prescriptions from 49 hospitals located in six major areas of China were included in the analysis. The yearly prescriptions containing antivirals increased from 8,819 in 2010 to 16,361 in 2019. The percentage of prescriptions for patients aged 65 years and above also increased (27.7% in 2010 to 31.0% in 2019), and the number of prescriptions for females was higher than those for males (P < 0.001). The average cost of antivirals per prescription decreased; thus, the yearly cost showed no increasing trend. The main prescribed antivirals were valaciclovir and famciclovir, which progressively increased in prescriptions. The use of acyclovir decreased during the study period. Prescriptions containing topical formulations, acyclovir and penciclovir, both increased. The DDCs of valaciclovir and famciclovir decreased dramatically.ConclusionThe use of antivirals has increased over the decade, while the cost has not. Antiviral treatments adhere well to recent recommendations, except for the use of topical antivirals. The findings of this study may benefit the healthcare source allocation and management of herpes zoster in China.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antiviral treatment in outpatients with herps zoster in six major areas of China, 2010–2019

Zhao

Jin

et al. 2022

Front. Public Health

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“…One recent systematic review indicated that the incidence rate of HZ has ranged from 5.23 to 10.9 per 1000 person years [ 3 ]. The incidence rates of HZ reported in other studies conducted in the United States (ranging from 4 to 7.2) [ 4 , 5 ], Canada (3 to 5) [ 6 , 7 ], United Kingdom (8.80) [ 8 ], Spain (8.29) [ 9 ], Germany (6.7) [ 10 ], China (6.64) [ 11 ], South Korea (1.87 to 5.1) [ 12 , 13 ], Japan (4.15 to 4.79) [ 14 , 15 ], and Taiwan (5.65) [ 16 ] revealed a trend of increasing incidence of HZ with increasing age, making the condition a major health burden on the elderly [ 17 , 18 ]. Thus, HZ has been a common clinical problem, with the elderly (defined in this context as those over 50 years of age) and immunocompromised patients again being especially susceptible [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Comparing Prodrugs with Acyclovir for Treating Postherpetic Neuralgia among Herpes Zoster Patients: A Systematic Review and Meta-Analysis

Yeh

Chang²,

Huang

et al. 2022

Healthcare

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Postherpetic neuralgia (PHN) is a common, painful, and long-term complication of herpes zoster (HZ). PHN increases the demand for healthcare services and, previous studies showed that patients who received antiviral agents were less likely to develop PHN. The objective of this study was to compare the efficacy of prodrugs and acyclovir in treating PHN among patients with HZ. The search included the PubMed, Medline, Embase, and Cochrane Center of Register of Controlled Trails databases through February 2022. Clinical trials and randomized controlled trials (RCTs) involving antiviral agent intervention for HZ patients diagnosed with PHN were eligible for inclusion. A meta-analysis was conducted to calculate pooled risk ratios (RRs) with 95% confidence intervals (CIs) with a fix-effect model. Five RCTs with 1147 HZ patients met our eligibility criteria. Our meta-analysis found that there was a significantly lower risk of PHN for members of the prodrugs group (famciclovir and valaciclovir) compared with those who received acyclovir (RR = 0.86, 95%, CI: 0.75 to 0.98, p = 0.03). The review of studies indicated that the efficacy of prodrugs was better than acyclovir for reliving PHN.

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“…Patients with immunode ciency, such as AIDS patients, were more susceptible to varicella-zoster virus infection and more likely to relapse than ordinary immune function people. varicella-zoster virus infection had a high incidence rate in China, approximately 7/1000 2 . It usually occured after the appearance of a skin rash.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Altered Spontaneous Brain Activity Patterns In Herpes Zoster Keratitis Using The Percent Amplitude of Fluctuation Method: A Resting-State Functional Magnetic Resonance Imaging Study

Liao

et al. 2021

Preprint

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Purpose: The purpose of this study was to use the percent amplitude of fluctuation (PerAF) to study the changes in brain activity and nerve function of herpes zoster keratitis (HZK) patients.Methods: We recruited 20 HZK patients and 20 healthy controls (HCs). Each of these groups included ten males and ten females and were matched in weight and age. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI). The percent amplitude of fluctuation (PerAF) method was used for analysis and detected differences between the two groups in the neurological function of brain areas. We also applied the receiver operating characteristic (ROC) curve to analyze the two groups and did a correlation analysis between the PerAF value, anxiety, and depression score, and visual acuity.Results: The PerAF signal at the right putamen and right precentral gyrus were significantly higher in patients than in HCs. However, the PerAF value of the left inferior temporal was lower in patients than in HCs. In addition, the HZK patients' anxiety and depression score (HADS) and visual acuity (VA) negatively correlated with the PerAF value at the left inferior temporal gyrus. Conclusion: HZK patients had some changes in brain regions, and the changes were also related to their mood and visual acuity. These findings might contribute to other studies in the potential pathological mechanism, disease development, prognosis, and brain function in HZK patients.

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Incidence and disease burden of herpes zoster in the population aged ≥50 years in China: Data from an integrated health care network

Cited by 53 publications

References 53 publications

Antiviral treatment in outpatients with herps zoster in six major areas of China, 2010–2019

Antiviral treatment in outpatients with herps zoster in six major areas of China, 2010–2019

Comparing Prodrugs with Acyclovir for Treating Postherpetic Neuralgia among Herpes Zoster Patients: A Systematic Review and Meta-Analysis

Investigation of Altered Spontaneous Brain Activity Patterns In Herpes Zoster Keratitis Using The Percent Amplitude of Fluctuation Method: A Resting-State Functional Magnetic Resonance Imaging Study

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