Incidence and disease burden of prostate cancer from 1990 to 2017: Results from the Global Burden of Disease Study 2017

Abstract

BACKGROUND: The patterns of the incidence and mortality of prostate cancer (PC) have been changing over the years. In addition, the unclear etiology of PC necessitates further studies into the geographic distribution and age composition of patients with PC. This study was aimed at examining the patterns of the epidemiology of PC to help policymakers to allocate the limited resources of the health care system accordingly. METHODS: Annual case data and age-standardized rates (ASRs) were obtained for the incidence, mortality, and disability-adjusted life-years (DALYs) of PC according to age from 1990 to 2017 and for 21 regions, including 195 countries and territories. The estimated annual percentage changes (EAPCs) of ASRs were calculated to evaluate the incidence and mortality trends of PC. RESULTS: Worldwide, the age-standardized incidence rate (ASIR) of PC increased from 30.5 cases per 100,000 population in 1990 to 37.9 cases per 100,000 population in 2017 with an EAPC of 0.59 (95% confidence interval [CI], 0.49-0.7), whereas the mortality decreased with an EAPC of −0.73 (95% CI, −0.80 to −0.67). The ASIR was positively associated with the sociodemographic index (SDI) in most regions, and the increase in the ASIR was steeper with a higher SDI. The proportion of patients younger than 65 years increased from 23.6% in 1990 to 27.3% in 2017. CONCLUSIONS: The incidence of PC has been increasing globally, whereas its mortality and DALYs have been decreasing. These trends are particularly significant in developed regions and vary across geographic regions. Adjustments to the medical strategy by governments and medical institutions are required.

Preoperative Nutritional Evaluation of Elderly Patients with Prostate Cancer Undergoing Laparoscopic Radical Prostatectomy

“…The incidence and mortality of PCa increased with age. In 2017, more than 70% of PCa patients were over 64 years old in the world, and 80% of PCa deaths were more than 65 years old [21], which was in line with the applicable age range of GNRI .…”

Epidemiological trends of women’s cancers from 1990 to 2019 at the global, regional, and national levels: a population-based study

“…In the calculating formula y = βx + α, x refers to calendar year, and y refers to log10 (age-standardized rate). EAPC was calculating as following: EAPC = 100* (10^β -1) [ 15 , 17 – 19 ]. When EAPC value and its 95 % confidence interval (CI) are greater than zero, the age-standardized rate is upward.…”

Epidemiological trends of tracheal, bronchus, and lung cancer at the global, regional, and national levels: a population-based study

“…Annual data on TBL cancer were derived from the Global Health Data Exchange (GHDx) query tool (http://ghdx.healthdata.org/gbd-results-tool), including cases, deaths, and DALYs. The basic instructions of the GBD study and the methods for estimating the cancer burden have already been introduced in our previous studies [8][9][10][11]. More GBD 2017 study data information was listed in Additional file 1.…”