Incidence and distribution of ocular disorders in the first year of life

Mansukhani, Sasha A.; Bothun, Cole E.; Xu, Timothy T.; Hendricks, Tina M.; Hodge, David O.; Bothun, Erick D.; Mohney, Brian G.

doi:10.1016/j.jaapos.2023.02.002

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…This nding is consistent with previous studies that have reported a similar sex distribution among screened infants. 12 The mean age of the participants was 3.35 ± 2.95 months, with the majority falling into the 1-3 month age group (52.5%). This result suggests that the screening program was successful in reaching infants at an early stage, allowing for early detection and intervention.…”

Section: Discussionmentioning

confidence: 92%

“…This nding is consistent with previous studies that have reported similar rates of normal ndings in screened infants. 9,12,13 However, a signi cant number of infants (41.4%) were diagnosed with various eye diseases. The leading causes of eye diseases among the screened infants were bacterial conjunctivitis (24.6%), congenital nasolacrimal duct obstruction (5.7%), epiblepharon (3.3%), and neonatal conjunctivitis (1.2%).…”

Section: Discussionmentioning

confidence: 99%

“…Similar prevalence rates of these eye diseases have been reported in other studies. 12,14 Interestingly, a family history of childhood ocular illness in rst-degree relatives was reported in nine infants, with congenital cataract, childhood squint, and high myopia being the most common conditions. This emphasizes the role of genetic factors in the development of certain eye diseases and highlights the importance of assessing family history during screenings.…”

Section: Discussionmentioning

confidence: 99%

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Eye disease screening in infants attending vaccination clinic in Butajira town, Ethiopia

Gebrekidan,

Teshome

2023

Preprint

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Background: Timely and periodic screening of eye diseases in infants is critical for the detection of visual impairment and its etiology as well as to plan early intervention.The aim of this study was to identify infants with eye disorders who visited the vaccination clinic. Methods: A cross-sectional study was conducted in infants visiting the vaccination clinic in Butajira town, Ethiopia, from August 1 to 31, 2022. Screening activities included parental reports of ophthalmic complaints, family history of childhood ocular illnesses, and risk factors for retinopathy of prematurity (ROP). The screening procedure involved assessing vision, adnexia, ocular motility, Hirschberg's test, pupils, red reflex, and anterior/posterior segments. Data collected were analyzed to determine the prevalence and types of eye disorders. The relationship between predictor variables and the presence or absence of diseases was assessed. Results: Out of 244 screened infants, 51.2% were female and 48.8% were male. The mean age was 3.35 ± 2.95 months, with the majority falling into the 1-3 month age group (52.5%). Diagnoses were made in 41.4% of infants. The causes of eye diseases were bacterial conjunctivitis (24.6%), congenital nasolacrimal duct obstruction (5.7%), and epiblepharon (3.3%). A family history of childhood ocular illness in first-degree relatives was reported in 3.7% of infants. Risk factors for retinopathy of prematurity were identified in 2.4% of neonates. The findings showed that no predictor variable was statistically significant in predicting the presence of diseases. Conclusions: Vaccination clinics could serve as important sites of eye screening in infants to identify common eye diseases and risk factors for ocular illness, such as risk factors for retinopathy of prematurity or family history of childhood eye diseases.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Eye disease screening in infants attending vaccination clinic in Butajira town, Ethiopia

Gebrekidan,

Teshome

2023

Preprint

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Infant and early childhood physical health assessments in the HEALthy Brain and Child Development (HBCD) Study

Cioffredi,

Garner,

Maxwell

et al. 2024

Developmental Cognitive Neuroscience

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From Preformulative Design to In Vivo Tests: A Complex Path of Requisites and Studies for Nanoparticle Ocular Application. Part 1: Design, Characterization, and Preliminary In Vitro Studies

Cimino,

Zingale,

Bonaccorso

et al. 2024

Mol. Pharmaceutics

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Ocular pathologies are widely diffused worldwide, and their effective treatment, combined with a high patient compliance, is sometimes challenging to achieve due to the barriers of the eye; in this context, the use of nanoparticles for topical ophthalmic application could represent a successful strategy. Aiming to develop nanoplatforms with potential clinical applications, great attention has to be paid to their features, in relation to the route of administration and to the pharmacopoeial requirements. This review (part 1) thus embraces the preliminary steps of nanoparticle development and characterization. At the beginning, the main barriers of the eye and the different administration routes are resumed, followed by a general description of the advantages of the employment of nanoparticles for ocular topical administration. Subsequently, the preformulative steps are discussed, deepening the choice of raw materials and determining the quantitative composition. Then, a detailed report of the physicochemical and technological characterization of nanoparticles is presented, analyzing the most relevant tests that should be performed on nanoparticles to verify their properties and the requisites (both mandatory and suggested) demanded by regulatory agencies. In conclusion, some preliminary noncellular in vitro evaluation methods are described. Studies from in vitro cellular assays to in vivo tests will be discussed in a separate (part 2) review paper. Hence, this overview aims to offer a comprehensive tool to guide researchers in the choice of the most relevant studies to develop a nanoplatform for ophthalmic drug administration.

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Incidence and distribution of ocular disorders in the first year of life

Cited by 4 publications

References 23 publications

Eye disease screening in infants attending vaccination clinic in Butajira town, Ethiopia

Eye disease screening in infants attending vaccination clinic in Butajira town, Ethiopia

Infant and early childhood physical health assessments in the HEALthy Brain and Child Development (HBCD) Study

From Preformulative Design to In Vivo Tests: A Complex Path of Requisites and Studies for Nanoparticle Ocular Application. Part 1: Design, Characterization, and Preliminary In Vitro Studies

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