Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Bullous Diseases French Study Group

Bernard, Philippe; Vaillant, L.; Labeille, B.; Bédane, Christophe; Arbeille, B.; Denoeux, J. P.; Lorette, G; Bonnetblanc, Jean-Marie; Prost, Cathérine

doi:10.1001/archderm.131.1.48

Cited by 236 publications

(228 citation statements)

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“…The annual incidence of BP calculated from our database was 3.4 per 100 000 population, which is consistent with the previously reported incidence rate, ranging from 0.7 to 4.3 per 100 000 per year. 1,[21][22][23] According to the literature, patients diagnosed with BP are more likely to have a history of cerebral stroke, ranging from 7.7% to 19.1%. 12,24 -26 To avoid any confusion caused by pre-existing cerebrovascular disease, patients with a history of any type of stroke before the onset of BP were excluded from this study.…”

Section: Discussionmentioning

confidence: 99%

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Increased Risk of Stroke in Patients With Bullous Pemphigoid

Yang

Chen

Xirasagar

et al. 2011

Stroke

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Background and Purpose-Although previous research reveals that cardiovascular events and thromboembolic diseases are important causes of death in patients with bullous pemphigoid (BP), the risk of stroke after the diagnosis of BP relative to the general population remains unknown. Using a randomly selected nationwide population-based sample, this study investigates the risk of stroke in patients with BP compared with unaffected individuals of a similar age. Methods-This study analyzes data from Taiwan's National Health Insurance Research Database. This sample included 390 patients with BP and 1950 matched subjects as a comparison group. Stratified Cox proportional hazard regressions were used to calculate the 3-year stroke risk for these 2 groups after adjusting for patient's age, sex, and comorbid medical disorders at baseline. Results-Of the 2340 patients in the sample, 312 patients (13.3%) had strokes during the 3-year follow-up period, 89(22.8% of the patients with BP) in the study group and 223 (11.4% of patients without BP) in the comparison group (PϽ0.001). The hazard ratio for stroke for patients with BP was 2.37 (95% CI, 1.78 to 3.15; PϽ0.001) times as high that for patients without BP within the 3-year follow-up period after adjusting for hypertension, diabetes, hyperlipidemia, heart failure, atrial fibrillation, and coronary heart disease. Conclusions-Patients

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Section: Discussionmentioning

confidence: 99%

“…1,2 Immunologic indicators of BP include the presence of IgG autoantibodies. These antibodies target proteins in the keratinocyte hemidesmosome, a basal cell basement membrane adhesion structure, resulting in subepidermal blister formations.…”

mentioning

confidence: 99%

Increased Risk of Stroke in Patients With Bullous Pemphigoid

Yang

Chen

Xirasagar

et al. 2011

Stroke

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“…On the other hand, bullous pemphigoid (BP) is uncommon, with an annual frequency of about 1 new case per 100,000 people, and is seen predominantly in middle aged and older individuals (3,4). It has been reported that the true coincidence rate of these two entities is higher than it would be predicted on the basis of their random distribution in the general population (5), suggesting some kind of link between them.…”

Section: Introductionmentioning

confidence: 99%

Coexistence of psoriasis and pemphigoid - only a coincidence?

Łazarczyk

Woźniak²,

Ishii³

et al. 2006

Int J Mol Med

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Abstract. It has previously been reported that pemphigoid coexists with psoriasis more frequently than it could be predicted on the basis of random distribution in the general population. In this study we present three psoriatic patients who developed tense blisters, which most likely were not provoked by anti-psoriatic treatment. Diagnosis of bullous pemphigoid in these cases was established by an overlay antigen mapping technique by laser confocal microscopy, immunoblotting and ELISA. In the context of these cases and the literature, we also discuss possible reasons for the coexistence of psoriasis and pemphigoid as well as selected aspects of diagnosis and therapy of patients simultaneously suffering from these two diseases.

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“…EBA is one of the rarest autoimmune blistering diseases with an incidence of 0.2-0.5/million inhabitants/year [19][20][21][22][23]. In a recent analysis of data from the largest German insurance company from 2014, the prevalence of EBA was calculated to be 2.84/million inhabitants, i.e.…”

Section: Epidemiologymentioning

confidence: 99%

Clinical features and diagnosis of epidermolysis bullosa acquisita

Vorobyev

Ludwig

Schmidt

2016

Expert Review of Clinical Immunology

100

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Introduction: Epidermolysis bullosa acquisita (EBA) is a rare autoimmune blistering disease of skin and mucous membranes. EBA is caused by autoantibodies against type VII collagen, which is a major component of anchoring fibrils, attaching epidermis to dermis. Binding of autoantibodies to type VII collagen leads to skin fragility and, finally, blister formation. The clinical picture of EBA is polymorphic, with several distinct phenotypes being described. Despite recent progress in understanding the pathophysiology of EBA, its diagnosis is still challenging. Areas covered: This review provides an update on the clinical manifestations and diagnostic methods of EBA. We searched PubMed using the terms 'epidermolysis bullosa acquisita' covering articles in English between 1 January 2005 and 31 May 2016. Relevant older publications were retrieved form cited literature. Expert commentary: While the clinical picture is highly variable, diagnosis relies on direct immunofluorescence (IF) microscopy of a perilesional skin biopsy. Linear deposits of IgG, IgA and/or C3 along the dermal-epidermal junction with an u-serrated pattern are diagnostic for EBA alike the detection of serum autoantibodies against type VII collagen. Several test systems for the serological diagnosis of EBA have recently become widely available. In some patients, sophisticated diagnostic approaches only available in specialized centers are required. ARTICLE HISTORY

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Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Bullous Diseases French Study Group

Cited by 236 publications

References 0 publications

Increased Risk of Stroke in Patients With Bullous Pemphigoid

Increased Risk of Stroke in Patients With Bullous Pemphigoid

Coexistence of psoriasis and pemphigoid - only a coincidence?

Clinical features and diagnosis of epidermolysis bullosa acquisita

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