Incidence and Early Course of Retlnonathy of Prematurity

Hardy, Robert J.; Phillips, Cynthia L.; Tung, Betty; Elsas, Frederick J.; Botsford, Jan M.; Braune, Karen W.; Cassady, George; Jones, John A.; Kimble, James A.; Kline, Lanning B.; Witherspoon, Douglas C.; Young, Matthew; Roth, Alan M.; Demorest, Byron H.; Erickson, Roberta; Gilbert, W. S.; Chrousos, Georgia Antonakou; Friendly, David S.; Jaafar, Mohammad; Keys, Marshall P.; Kolsky, Martin P.; Mercer, Patricia Ann; O'Neill, Donna; O’Neill, John; Parelhoff, Edward S.; Perraut, Ed; Pilkerton, A. Raymond; Plotsky, David; Flynn, John T.; Clarkson, John G.; Lopez, Gabrielle; Miller, Marilyn T.; Bhat, Rama; Cohen, Steven B.; Cronin, Cathleen M; Daily, Mark J.; Gagliano, Donald A.; Gieser, Richard G.; Haldi, Betty Anne; McCulloch, Kristine M.; Mittelman, David; Raju, Tonse N.K.; Sheftel, David; Skuran, Kathleen; Sobel, Daniel B.; Squires, Peggy; Vygantas, Charles M.; Ellis, Forrest D.; Archer, Stephen D.; Helveston, Eugene M.; Julian, Ken; Reed, Gayle; Schreiner, Richard L.; Barr, Charles C.; Adamkin, David N.; Douglas, Craig; Whittington, Gregory K.; Wilkerson, Shirley A.; Gordon, Robert A.; Bushaw, Carolyn; DeVoe, W. M.; Diamond, James G.; Gill, William L.; May, Donald R.; Reynolds, Jane; Storch, Thomas G.; Bustros, Serge de; Alford, Alethia; Graeber, Janet E; Repka, Michael X.; Trese, Michael T.; Baker, John D.; Hatem, Ghaleb F.; Manatrey, Patricia; Medalis, Doreen; Ramsay, Robert C.; Summers, C. Gail; Cameron, J. Douglas; Chisholm, Kim I.; Heikenen, Rebecca; Irlbeck, Donna K.; Janda, Alvina M.; Kopietz, Leslie A.; Kriedeman, Robin; Lavoie, Jane D.; Maxwell, Molly; Pier, Ted R.; Rodman, William P.; Witt, Patty; Woody, Amy; Phelps, Dale L.; Torrisi, Paul F.; Zak, Thaddeus A; Cohen, Kathy; Dave, Rajesh J.; Guillet, Ernest G.; Hakanson, David O.; Hampton, Robert; Merriam, Walter W.; Metz, Henry S.; Pronobis, Ellen; Simon, Richard; Vanderlinde, Robert E.; Wood, Nancy; Zehl, Donald N.; Buckley, Edward; Anderson, Malcolm M.; Valentine, G. H.; Wong, Susie; Burke, Miles J.; Johnson, Judith; Rogers, Gary L.; Bremer, Don L.; Cordero, Leandro; Fellows, Rae R.; Hansen, Nancy B.; McClead, Richard E.; Palmer, Earl A.; Aaby, Arthur A.; Banagale, Raul C.; Benda, Gerda I.; Binder, Nancy D.; Brown, William J.; Gilhooly, Joseph; Goodman, Shawn S.; Huston, Robert K.; LaFrance, Susan B.; Lewallen, Patrick K.; McDonald, John V.; Murphy, David L.; Reynolds, John W.; Robertson, Joseph E.; Tongue, Andrea Cibis; Schaffer, David B.; Bowen, Frank W.; Delivoria‐Papadopoulos, Maria; Desai, Hemant; Diamond, Gary R.; Giannetta, Joan M.; Naidoff, Michael A.; Peckham, George J.; Pleasure, Jeanette R.; Porat, Rachael; Quinn, Graham E.; Biglan, Albert W.; Brown, David R.; Doft, Bernard H.; Eller, Andrew W.; Lobes, Louis A.; Saunders, Richard; Christmann, Linda M.; Austin, Tom L.; Berkeley, Lesley; Ferguson, James; McWilliams, Wilson G.; Miller, Karen W.; Pai, Sharada; Pakalnis, Vytautas A.; Purohit, Dilip M.; Feman, Stephen S.; Cotton, Robert B.; Elliott, James H.; Law, Amy B; Steele, Steven; Spencer, Rand; Berry, Priscilla M.; Fish, Gary E.; Fuller, Dwain G.; Hutton, William L.; Lefer, Joel; Manning, Jean R.; Sanborn, George E.; Snyder, William B.; Stager, David R.; Heuven, W. A. J. Van; Escobedo, Marilyn; Montez, Maria G.; Speights, James W.; Kivlin, Jane D.; Bracken, Susan; Carver, John A.; Dolcourt, Jack L.; Hoffman, Robert O.; Teske, Michael P.; Williams, A. Thomas

doi:10.1016/s0161-6420(91)32074-8

Cited by 567 publications

(135 citation statements)

References 19 publications

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“…33 The ETROP study generally corroborated RM-ROP2 risk estimates, demonstrating improved structural and functional outcomes in the early treatment group. However, the study authors estimated that early treatment based on the RM-ROP2 risk estimates alone would have resulted in the unnecessary treatment of 37% of high-risk prethreshold eyes that would have regressed without reaching threshold.…”

Section: Discussionsupporting

confidence: 55%

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

et al. 2007

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Objective: To test cumulative neonatal illness severity (IS) and IS fluctuation as predictors of progression from moderate to severe retinopathy of prematurity (ROP).Study Design: Data from research databases and medical record review were collected for infants from four neonatal intensive care unit (NICUs) admitted between 1995 and 2001 and diagnosed with prethreshold ROP. Cumulative neonatal IS measured using daily Scores for Neonatal Acute Physiology (SNAP) for the first 28 days of life, and IS fluctuation as assessed by summing changes between daily SNAP scores, were tested as predictors of progression to threshold ROP using logistic regression.Result: Infants progressing to threshold (n ¼ 79), compared to those not progressing to threshold (n ¼ 130), had significantly (P<0.05) lower gestational ages (25.2±1.1 versus 25.8±1.4 weeks), higher cumulative neonatal SNAP (255±77 versus 224±63 weeks) and had more severe hospitalizations as indicated by diagnoses and medical management. In regression analysis, gestational age, chronological age and presence of plus disease at first diagnosis of prethreshold were associated with development of threshold. After adjusting for these factors, cumulative neonatal SNAP was significantly associated with progression to threshold. However, addition of cumulative SNAP to the model only increased receiver-operating characteristic curve area from 0.77 to 0.78 (NS). Other factors, including SNAP fluctuation, were not associated with progression to threshold after adjustment using this model. Conclusion:Cumulative neonatal IS, as measured by cumulative SNAP, is an independent risk factor for progression from moderate to severe ROP. However, cumulative IS does not enhance assessment of risk for ROP progression after adjusting for simpler clinical factors.

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Section: Discussionsupporting

confidence: 55%

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

et al. 2007

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“…Also suggested by the authors was a single screening examination at 37 weeks PMA for those infants with a birth weight from 1200 to 1800 g, to include possible outliers. Our study data and data from the Cryo-ROP study 7 also support a 'spot exam' at 37 weeks PMA. This examination could also occur just prior to discharge, as close to 37 weeks of PMA as possible, to prevent loss to follow-up.…”

supporting

confidence: 72%

“…This concept is also supported by data from the Cryo-ROP study. 7,9 Do we have evidence to support weekly examinations, in the presence of any ROP?…”

Section: When Should the First Examination Occur?mentioning

confidence: 99%

Severe retinopathy of prematurity: longitudinal observation of disease and screening implications

Ells

Hicks

Fielden

et al. 2004

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Purpose To test the effectiveness of our Canadian retinopathy of prematurity (ROP) screening guidelines as applied to high-risk premature infants. Study Design Retrospective longitudinal cohort study. Subjects A total of 969 infants were examined longitudinally between 1991 and 2000 and 46 of these infants screened were treated for severe ROP. Methods Data from weekly ROP screening examination results were collected from a geographical area and analysed. Results The average incidence of severe ROP requiring treatment in the population of premature infants eligible for screening was 48.3 per 1000. In all, 46 infants were treated in this cohort. The mean gestational age (GA) was 25.5 weeks of age and the mean birth weight was 750 g. The mean chronological age (CA) and postmenstrual age (PMA) at the time of first screening was 36 days and 30.7 weeks, respectively. The first identification of any ROP in this group was at a mean CA 60 days and PMA of 34.1 weeks. The mean CA and PMA of the first observation of stage 3 were 74 days and 36.3 weeks. The mean CA and PMA at the time of treatment were 86 days and 37.7 week. Conclusions Our observations and analysis indicate the following ROP screening recommendations: infants of 28 weeks of GA or less, infants with a GA between 28 weeks and 30 weeks should have a single 'spot examination' at approximately 37 weeks of PMA (or prior to discharge from hospital) to include possible outliers; infants born with a birth weight of 1250 g or less; initial screening examination should be at 31 weeks of PMA or 4 weeks of CA, whichever is later; in the presence of any active ROP, the infant should be followed every 1-2 weeks; and stage 3 should be followed at least every 7 days.

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“…[1][2][3][4] Candida spp. are the third most common cause of late-onset sepsis in neonatal intensive care units (NICUs), 1 and ROP occurs in 40-80% of preterm neonates.…”

Section: Introductionmentioning

confidence: 99%

Fungal and bacterial sepsis and threshold ROP in preterm very low birth weight neonates

et al. 2005

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Objective: To determine whether an association exists between either fungal or bacterial sepsis and retinopathy of prematurity (ROP).Study Design: Retrospective cohort study on all neonates with birth weight <1500 g admitted to a large Italian third Level Neonatal Intensive Care Unit in the years 1997-2001 and screened for ROP. Univariate analysis and multiple logistic regression were used to detect significant associations with ROP (all grades and threshold) in neonates with birth weight <1000 g (extremely low birth weight (ELBW)) and 1000-1500 g. Results:Among 301 enrolled neonates, ROP (all grades), threshold ROP, fungal and bacterial sepsis occurred in 31.9, 12.9, 11.6 and 40.5% of the infants, respectively. At multivariate analysis, only gestational age (P ¼ 0.03), colonization by Candida non-albicans spp (P ¼ 0.03) and fungal sepsis (P ¼ 0.03) were independent predictors of threshold ROP, and only in ELBW neonates.Conclusions: Fungal (but not bacterial) sepsis is significantly and independently associated with ROP, but only in ELBW neonates and only with threshold ROP.

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Incidence and Early Course of Retlnonathy of Prematurity

Cited by 567 publications

References 19 publications

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

Cumulative illness severity and progression from moderate to severe retinopathy of prematurity

Severe retinopathy of prematurity: longitudinal observation of disease and screening implications

Fungal and bacterial sepsis and threshold ROP in preterm very low birth weight neonates

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