Incidence and factors influencing on Helicobacter pylori infection recurrence

Abstract

Objectives: a) to determine the rate of H. pylori reinfection after successful eradication in a 4-year follow-up study; and b) to evaluate the contribution of different factors in the infection relapse.Patients and methods: a total of 208 patients (age range 18-81 years; average 50 years; 87 women) who had been successfully treated for H. pylori infection were included. Annually, urea breath test was assessed to determine H. pylori status after eradication. Age, sex, rural/urban environment, smoking habit, treatment regimens against H. pylori and urea breath test values were evaluated.Results: reinfection occurred in 9,6% of patients observed, 6,7% (14/208) in the first year, 1,9% (4/208) in the second year, 1% (2/208) in the third and 0% in the forth. Risk factors for infection recurrence were younger age and higher values of urea breath test in the multivariante analysis.Conclusions: annual reinfection rate was 2,4 pacients-year. Younger patients and higher values of urea breath test were factors associated with a higher rate of reinfection relapse. Annually, urea breath test should be performed to detect reinfection in order to avoid ulcer complications.

Recurrence of Helicobacter pylori infection after several eradication therapies: long‐term follow‐up of 1000 patients

“…which found that risk of reinfection amongst children under 5 years old was 26 times higher than that amongst older individuals. Likewise, some studies have observed that the average age of reinfected patients is lower than that of patients who remain H. pylori negative, 23–26 although other studies performed in children could not confirm that the risk of reinfection depends on age 27 . The reason for this relationship between lower age and H. pylori recurrence is unknown, nor is it known whether it is due to differences in the distribution of other risk factors among age groups.…”

Long-term follow up Helicobacter Pylori reinfection rate after second-line treatment: bismuth-containing quadruple therapy versus moxifloxacin-based triple therapy

“…Limited information exists regarding risk factors for reinfection of H. pylori . Candidate risk factors include younger age [ 26 , 27 ], infection of close contacts [ 14 , 28 ], dental plaque [ 29 , 30 ], and contaminated endoscopic equipment [ 14 , 16 , 31 ]. Other studies did not identify any factors predictive of H. pylori reinfection [ 32 - 34 ].…”

Long‐term Follow‐up Helicobacter Pylori Reinfection Rate and Its Associated Factors in Korea

“…Currently, limited information exists regarding risk factors for reinfection of H. pylori . Some factors have been proposed as risk factor for reinfection, such as younger age , infection of close contacts , dental plaque , and contaminated endoscopic equipment . One report suggested that past history of peptic ulcer disease or identification of ulcer at the time of esophagogastroduodenoscopy was risk factor associated with reinfection .…”