Incidence and features of eosinophilic esophagitis in dysphagia: a prospective observational study

Murray, Iain A.; Joyce, Stephne; Palmer, Joanne; Lau, Michael; Schultz, Michael

doi:10.3109/00365521.2015.1093166

Cited by 14 publications

(3 citation statements)

References 23 publications

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“…We found a total of 152 cases of EoE in the Wellington region with an average annual incidence rate of 6.95 (95% CI 5.91, 8.12) cases per 100,000 persons over the last 5 years. A recent prospective observational study was conducted in Dunedin, New Zealand,23 but it only looked at the incidence and features of EoE in patients who presented with dysphagia. That study demonstrated that EoE was a common cause of dysphagia with an incidence of 14.1% in those having an esophageal biopsy.…”

Section: Discussionmentioning

confidence: 99%

<p>Eosinophilic esophagitis incidence in New Zealand: high but not increasing</p>

Weerasekera¹,

Sim²,

Coughlan³

et al. 2019

CEG

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Background and aim Eosinophilic esophagitis (EoE) is an immune-mediated inflammatory condition of the esophagus. Recent literature has shown an increasing incidence of the disease. However, no epidemiological data exist regarding New Zealand rates of EoE. The disease is associated with atopy, and New Zealand’s high rate of atopic disease means the disease may be important in our population. We carried out a retrospective study to describe the incidence of EoE in the Wellington region of New Zealand, as well as key histological and clinical factors associated with the disease. Method A search was made of laboratory and endoscopic databases in the Wellington region to identify all diagnosed cases in the five years between January 1, 2011, and December 31, 2015. Case notes were examined to determine the key demographic and clinical parameters in the cases. Incidence rates were calculated for each year, and the effects of age group and sex on the incidence rates were analyzed. Result We found 152 cases of EoE in the Wellington region with an annual incidence of 6.95 per 100,000 person/years. We found no evidence of a significant difference in incidence rates by year in our study population. There was a significantly lower incidence rate in those aged <16 compared to those aged ≥16 (RR=0.26). Males had a higher incidence rate than females with an estimated rate ratio of 2.45 ( p <0.05). Conclusion Our results are in contrast to previous reports of increasing incidence rates and may reflect a leveling off of incidence. Further research is needed to determine whether the low incidence in our pediatric age group is due to ascertainment bias or due to a real difference in the epidemiology of EoE in NZ compared to other countries.

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Section: Discussionmentioning

confidence: 99%

<p>Eosinophilic esophagitis incidence in New Zealand: high but not increasing</p>

Weerasekera¹,

Sim²,

Coughlan³

et al. 2019

CEG

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“…46, 47, 50 In studies assessing patients undergoing endoscopy for an indication of dysphagia, rates are higher, ranging from 12% to 23%. 62–66 The highest proportions of EoE, frequently above 50%, occur in patients presenting with an esophageal food bolus impaction—EoE is now the most common cause of esophageal food bolus impactions in patients presenting to emergency departments. 67–79 EoE has also be detected in 1%–8% of patients undergoing endoscopy for symptoms of refractory reflux or heartburn, 43, 54, 60, 65, 80–83 6% of patients undergoing endoscopy for non-cardiac chest pain, 84 4% of patients undergoing endoscopy for abdominal pain, 85 4% of patients with refractory aerodigestive symptoms, 86 and 5% of patients with IgE-mediated food allergies.…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology and Natural History of Eosinophilic Esophagitis

2018

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Eosinophilic esophagitis (EoE) has emerged over the past 2 decades as a major cause of upper gastrointestinal morbidity. Over this time, the epidemiology of EoE has also rapidly evolved. EoE has transformed from a rare case-reportable condition to disease that is commonly encountered in the gastroenterology clinic, hospital emergency room, and endoscopy suite. The incidence and prevalence are increasing at rates that outpace increased disease recognition. Current incidence estimates range from 5 to 10 cases per 100,000, and current prevalence estimates range from 0.5 to 1 case per 1000. We review the data and potential reasons behind this increase, examine risk factors, and identify important areas for research into disease etiology. The article also discusses the progression of EoE from an inflammatory to fibrostenotic phenotype. An accurate view of the natural history of EoE is central to discussions with patients regarding disease prognosis and decisions about long-term use of medical, endoscopic, and diet therapies. Progressive remodelling appears to be gradual, but not universal, and the duration of untreated disease is the best predictor of stricture risk. Ultimately, prospective, long-term outcome studies focusing on multiple aspects of disease activity are needed to fully understand the natural history of EoE.

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“…35 A New Zealand study found comparable reported frequencies with other European countries, but it also highlighted the low sensitivity (30%) of endoscopy for the diagnosis of EOE. 41 Endoscopic evaluation is recommended for patients with symptoms suggestive of EoE; however, as stated above, using the EREFS should be used more for descriptors than severity of disease, and a negative EREFS score should not prevent biopsies from being taken. Age at onset, symptoms at presentation, and endoscopic characteristics varied significantly amongst racial/ethnic groups as well as amongst genders.…”

Section: Discussionmentioning

confidence: 99%

Understanding the Sex, Racial, and Ethnic Disparities in Eosinophilic Esophagitis

Halabi

Malik

2023

Foregut: The Journal of the American Foregut Society

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The incidence of eosinophilic esophagitis (EoE) has been rapidly increasing. EoE affects both children and adults and can present with a variety of symptoms depending on age. Multiple studies have found that EoE is more common in Caucasian men compared with other genders or racial or ethnic groups; however, the basis for that predominance is still unknown. The varied clinical illness presentation and persistence in various ethnic groups begs the question of whether genetic or environmental factors might be contributors behind EoE. This paper will review the literature regarding epidemiology, risk factors, and genetic and ethnic differences in EoE.

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Incidence and features of eosinophilic esophagitis in dysphagia: a prospective observational study

Cited by 14 publications

References 23 publications

<p>Eosinophilic esophagitis incidence in New Zealand: high but not increasing</p>

<p>Eosinophilic esophagitis incidence in New Zealand: high but not increasing</p>

Epidemiology and Natural History of Eosinophilic Esophagitis

Understanding the Sex, Racial, and Ethnic Disparities in Eosinophilic Esophagitis

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