Incidence and Growth of Mammary Tumors Induced by 7, 12-Dimethylbenz[a]anthracene as Related to the Dietary Content of Fat and Antioxidant2

King, M. Margaret; Bailey, David M.; Gibson, Donald D.; Piťha, Jan; McCay, Paul B.

doi:10.1093/jnci/63.3.657

Cited by 77 publications

(13 citation statements)

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“…This observation was confirmed by others (18) and led to the conclusion that a highfat diet has an effect on ovarian function.…”

Section: Effect Of a High-fat Diet On Serum Estrogenssupporting

confidence: 67%

“…Rogers and Wetsel (17) reported that a diet containing 30% beef tallow + 2% vegetable oil retarded mammary carcinogenesis by N-2-fluorenylacetamide (AAF) or DMBA, compared to a diet containing 15% vegetable oil. King et al (18) demonstrated that mammary tumor incidence was lower in rats fed a diet containing 18% stripped hydrogenated coconut oil + 2% linoleic acid compared to rats on a 20% stripped corn oil diet. In the latter three experiments, there were sufficient amounts of essential fatty acids in the diets, yet rats on these diets exhibited reduced mammary tumor yield.…”

Section: Tumor Promotion In Mammary Carcinogenesis By Dietary Fatmentioning

confidence: 99%

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Hormones and Dietary Fat as Promoters in Mammary Carcinogenesis

Dao¹,

Chan²

1983

Environmental Health Perspectives

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Hormones, particularly ovarian steroids and pituitary prolactin, promote mammary carcinogenesis in rats treated with a carcinogen. Hormones also play a critical role during the initiation process as demonstrated by mammary carcinogenesis in ovariectomized rats. A diet high in fat content, especially polyunsaturated fat, promotes mammary tumorigenesis when it is fed to carcinogen-treated rats for a prolonged period of time. Although a high fat diet is not essential for neoplastic transformation of the mammary cells, its effect on initiation is demonstrated when it is fed to rats for a long duration. Thus, both hormones and high dietary fat play a dual function in mammary carcinogenesis. There are indications that dietary fat may modulate endocrine activities, but a relationship between dietary fat and endocrine function remains to be conclusively demonstrated.

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“…This observation was confirmed by others (18) and led to the conclusion that a highfat diet has an effect on ovarian function.…”

Section: Effect Of a High-fat Diet On Serum Estrogenssupporting

confidence: 67%

Section: Tumor Promotion In Mammary Carcinogenesis By Dietary Fatmentioning

confidence: 99%

Hormones and Dietary Fat as Promoters in Mammary Carcinogenesis

Dao¹,

Chan²

1983

Environmental Health Perspectives

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“…2 -9 Studies by Hopkins and West 25 also showed that feeding a diet high in polyunsaturated fat provided more favorable conditions for development of tumors in mice injected with cells from a transplantable mammary tumor. Furthermore, the experiments of Hillyard and Abraham 21 have shown that polyunsaturated fat promotes the development of transplantable tumors in mice and rats, and King et al 28 observed that the growth rate of mammary tumors induced in rats by DMBA was enhanced by feeding a diet high in polyunsaturated fat. Other studies have shown that polyunsaturated fatty acids stimulate normal alveolar growth of the mouse mammary gland 30 and enhance the growth and survival of normal and neoplastic rat mammary cells in culture.…”

Section: Mechanism Of Action Of Dietary Fat In Mammary Carcinogenesismentioning

confidence: 99%

Diet and carcinogenesis

Carroll

1981

Nutrition and Cancer

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Analysis of epidemiological data and experiments with animals have provided evidence that dietary fat has an important influence on mammary cancer. Further epidemiological studies should be carried out to examine this relationship more fully, and additional experimental work is required to determine the mechanisms by which dietary fat influences mammary cancer in animals. Dietary carbohydrate and minor dietary components, such as retinoids and certain trace elements, have also been shown to influence mammary cancer in animals. Decreasing the fat content of the diet may offer a practical means of reducing mortality from breast cancer, which continues to be a major cause of death in many parts of the world.

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“…This correlation has also been confirmed in both spontaneous and carcinogen-induced mammary tumors in mice (3) and rats (8)(9)(10). In addition, it has been established that polyunsaturated fat is more effective than is saturated fat in the enhancement of carcinogen-induced tumor development in the rat (11)(12)(13). Paired feeding experiments demonstrated that the tumorigenic effect of fat is independent of caloric intake (14).…”

Section: Introductionmentioning

confidence: 99%

The interaction of dietary fat and antiestrogen treatment on DMBA‐induced mammary tumors in the rat

King

Pento

Magarian

et al. 1985

Nutrition and Cancer

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This study was designed to determine whether an estrogenic mechanism is involved in dietary fat-modulated tumor development and growth. Female Sprague-Dawley rats were placed on a semipurified low-fat (2% fat), high-saturated fat (20% fat), or high-polyunsaturated fat (20% fat) diet at 21 days of age. A single dose of 7,12-dimethylbenz[a]anthracene (DMBA, 10 mg) was administered intragastrically at 50 days of age. Two studies were performed. One tested the effectiveness of antiestrogen treatment (either tamoxifen or analog II) on tumor development when it was given one week prior to and one week after DMBA treatment in animals consuming a high-polyunsaturated fat diet. The second six-week study tested the antiestrogen effectiveness in arresting tumor growth and in producing regressions of established DMBA-induced tumors in rats consuming various levels and types of fat. The results of these studies indicate that both antiestrogens employed reduced the rate of growth and increased the number of regressions of established DMBA-induced tumors. In general, this was true in animals fed diets with a high content of either saturated or polyunsaturated fats and to a lesser extent in animals fed a low-fat diet. Tamoxifen produced a somewhat greater reduction in the growth of established tumor than did analog II. However, analog II, which is a more biologically "pure" antiestrogen, reduced the incidence of animals with mammary tumors and total tumor burden when administered one week before and one week after DMBA dosing. Tamoxifen, which is a partial estrogen-agonist, did not alter tumor incidence, but it did reduce the total tumor burden under these same experimental conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

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Incidence and Growth of Mammary Tumors Induced by 7, 12-Dimethylbenz[a]anthracene as Related to the Dietary Content of Fat and Antioxidant2

Cited by 77 publications

References 0 publications

Hormones and Dietary Fat as Promoters in Mammary Carcinogenesis

Hormones and Dietary Fat as Promoters in Mammary Carcinogenesis

Diet and carcinogenesis

The interaction of dietary fat and antiestrogen treatment on DMBA‐induced mammary tumors in the rat

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