Incidence and lifetime risk of dementia and Alzheimer’s disease in a Southern European population

Lobò, Antonio; López-Antón, Raúl; Santabárbara, Javier; De‐la‐Cámara, Concepción; Ventura, Tirso; Quintanilla, Miguel; Roy, Juan F.; Campayo, Antonio; Lobo, Elena; Palomo, Tomás; Rodríguez‐Jiménez, Roberto; Saz, Pedro; Marcos, Guillermo

doi:10.1111/j.1600-0447.2011.01754.x

Cited by 68 publications

(83 citation statements)

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“…This reflects a known difference in survival between men and women, women dying at an older age than men and therefore having more time to develop dementia. This finding, however, is even more emphasized by the fact that even after taking into account age differences, women are known to have a higher prevalence of AD than men [4,12,13]. Gender differences are also described in the diagnostic workup to assess AD and in the disease evolution [14,15], both items that can also be studied using longitudinal BNA data.…”

Section: Discussionmentioning

confidence: 99%

“…It allows researchers to consider this variable, as the literature describes a relationship between education and the prevalence of dementia, in particular AD [12,13,16]. …”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the BNA does not cover all patients and all parts of France yet. In the literature, geographical differences (between countries but also regional differences within a country) have been described in reported dementia prevalences [13,22]. Second, there might be differential reporting as the participation rate depends on the type of center and caregiver.…”

Section: Discussionmentioning

confidence: 99%

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The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

Anthony¹,

Pradier²,

Chevrier³

et al. 2014

Dement Geriatr Cogn Disord

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Background: Alzheimer's disease (AD) is a major public health issue. The French National Alzheimer database (BNA) registers all medical acts performed by memory units and independent specialists throughout France. This article describes the national coverage, the registered patient characteristics and illustrates research possibilities. Methods: All data transmitted up to December 2012 were analyzed. The following patient characteristics were studied: age, sex, educational level, place of living, diagnosis, Mini-Mental State Examination score and existence of pharmacological or psychosocial interventions. Results: At the end of 2012, the BNA included 84% (n = 357) of all French memory units, contained 341,498 patients and more than 800,000 medical acts. AD accounted for 26.4% of all registered diagnoses, related disorders for 21.7% and mild cognitive impairment for 8.7%. Conclusion: The BNA offers a multitude of research possibilities. In the coming years, the BNA will play a major role in monitoring trends and related risk factors in AD.

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Section: Discussionmentioning

confidence: 99%

“…It allows researchers to consider this variable, as the literature describes a relationship between education and the prevalence of dementia, in particular AD [12,13,16]. …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

Anthony¹,

Pradier²,

Chevrier³

et al. 2014

Dement Geriatr Cogn Disord

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“…It has been proven that the incidence rate of AD increases greatly with age. 4,5 Especially, with an increased life expectancy and aging population, the number of Alzheimer's patients will rapidly increase as the world population grows and people live longer. So, the number is expected to increase to about 115 million in 2050 in the absence of an effective treatment.…”

Section: Introductionmentioning

confidence: 99%

Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations

Liu

Bai

et al. 2012

The Journal of Chemical Physics

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Aggregation of amyloid-β (Aβ) peptides correlates with the pathology of Alzheimer's disease. However, the inter-molecular interactions between Aβ protofibril remain elusive. Herein, molecular mechanics Poisson-Boltzmann surface area analysis based on all-atom molecular dynamics simulations was performed to study the inter-molecular interactions in Aβ(17-42) protofibril. It is found that the nonpolar interactions are the important forces to stabilize the Aβ(17-42) protofibril, while electrostatic interactions play a minor role. Through free energy decomposition, 18 residues of the Aβ(17-42) are identified to provide interaction energy lower than -2.5 kcal/mol. The nonpolar interactions are mainly provided by the main chain of the peptide and the side chains of nine hydrophobic residues (Leu17, Phe19, Phe20, Leu32, Leu34, Met35, Val36, Val40, and Ile41). However, the electrostatic interactions are mainly supplied by the main chains of six hydrophobic residues (Phe19, Phe20, Val24, Met35, Val36, and Val40) and the side chains of the charged residues (Glu22, Asp23, and Lys28). In the electrostatic interactions, the overwhelming majority of hydrogen bonds involve the main chains of Aβ as well as the guanidinium group of the charged side chain of Lys28. The work has thus elucidated the molecular mechanism of the inter-molecular interactions between Aβ monomers in Aβ(17-42) protofibril, and the findings are considered critical for exploring effective agents for the inhibition of Aβ aggregation.

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“…Según la Organización Mundial de la Salud, esta enfermedad, atendiendo a sus efectos devastadores sobre las personas que la padecen, sus familias, sus comunidades y los sistemas nacionales de salud, podemos decir que se manifiesta como una crisis de salud pública "con (VVAA, 2013). El estudio llevado a cabo por Lobo (2011) en España con un seguimiento de una co horte de 4057 individuos cognitivamente intactos mayores de 55 años de edad que viven en Zaragoza, muestra que la tasa de incidencia de la demencia fue de 8,6 por 1000 y la de EA de 5,4 por 1000. También De Pedro-Cuesta et al (2009) llevaron a cabo un estudio, centrándose en el centro y noreste de España, en el que se pretendía conocer en qué grado afecta a la población las demencias más frecuentes en España.…”

Section: Introductionunclassified

Música y palabra contra el alzheimer

Vernia

Martí

2017

Arte Individ. Soc.

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Resumen. Este artículo muestra los resultados obtenidos en un proyecto llevado a cabo entre una residencia para personas mayores y la Universidad Jaume I de Castellón nacido a raíz de un premio convocado por ambas instituciones. Se llevó a cabo la implementación de diferentes actividades con el objetivo de incidir positivamente en la memoria y la calidad de vida de las personas residentes. Estas actividades estuvieron fundamentadas, por una parte, por la metodología Dalcroze "la Euritmia" y por otra parte, por las "Historias de Vida". La aplicación corrió a cargo del profesorado de la Universidad mencionada y bajo la supervisión de una psicóloga externa, quien seleccionó los cuestionarios para pasar a la muestra y, a través del programa SPSS gestionó los resultados. El proyecto se llevó a lo largo de 28 sesiones, que aunque supone una escasa temporalidad, atendiendo a los resultados obtenidos nos llevan a plantear la continuidad del proyecto. Cabe destacar la mejora en la calidad de vida de los participantes y su disposición a seguir colaborando. Palabras clave: Euritmia; historias de vida; Alzheimer; calidad de vida personas mayores.[en] Music and word against Alzheimer Abstract. The aim of this article is to show the results obtained in a project between a nursing home and the Jaume I University in Castellón. It was born from a proposed prize of both establishments. Some activities were implemented in order to contribute positively to the memory and the quality of life of the residents. On the one hand, these activities were based on Dalcroze Method: the Eurhythmics. On the other hand they are based on life histories. The appliance was implemented by teachers of the mentioned University and supervised by an external psychologist. She chose the questionnaires to be taken and, through the SPSS programme, managed the results. Despite the limited time, the project lasted 28 sessions and thanks to the success of its results we propose the continuity of the project. It is worth stressing the improvements in the participants' standards of living and their disposal to continue working together. Keywords: Eurhythmics; life histories; Alzheimer; quality of life for the elderly. Sumario

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Incidence and lifetime risk of dementia and Alzheimer’s disease in a Southern European population

Abstract: The incidence rate of dementia in this Southern European city was slightly lower than in previous studies in North-West Europe. LTR of dementia and AD seems to be slightly increased with age. The association of illiteracy with higher LTR of AD is intriguing.

Cited by 68 publications

References 50 publications

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

The French National Alzheimer Database: A Fast Growing Database for Researchers and Clinicians

Exploring the inter-molecular interactions in amyloid-β protofibril with molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area free energy calculations

Música y palabra contra el alzheimer

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