Incidence and mortality of adult respiratory distress syndrome: A prospective analysis from a large metropolitan hospital

Baumann, William T.; Jung, Ralph C.; Koss, Michael N.; Boylen, C. Thomas; Navarro, Leticia; Sharma, Om P.

doi:10.1097/00003246-198601000-00001

Cited by 92 publications

(25 citation statements)

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“…Survival in ARDS is influenced by a number of characteristics of the study population including demographics (particularly age) [19], aetiology [2,6,14], severity of the disease [19][20][21] and differences in patient management [22][23][24][25]. Table 4 shows that our survival data are comparable to those previously reported.…”

Section: Survivalsupporting

confidence: 69%

“…Although our understanding of the pathophysiology of the acute respiratory distress syndrome (ARDS) has improved in the 28 years since its first description by Ashbaugh et al [1], its mortality remains high, with the usually quoted range being between 50 and 80 %, depending upon the underlying aetiology [2][3][4][5][6]. ARDS due to sepsis and pneumonia has been associated with a particularly high mortality [6,7], whereas ARDS secondary to trauma is usually associated with a better prognosis [8].…”

Section: Introductionmentioning

confidence: 99%

“…ARDS due to sepsis and pneumonia has been associated with a particularly high mortality [6,7], whereas ARDS secondary to trauma is usually associated with a better prognosis [8].…”

Section: Introductionmentioning

confidence: 99%

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Acute respiratory distress syndrome in a community hospital ICU

Nolan

Burgess

Hopper

et al. 1997

Intensive Care Medicine

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Section: Survivalsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

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Acute respiratory distress syndrome in a community hospital ICU

Nolan

Burgess

Hopper

et al. 1997

Intensive Care Medicine

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“…Intratracheal administration of LPS serves as a model for gram-negative sepsis and gram-negative pneumonia, two of the most common causes of ALI in humans (25). Influenza A (specifically the H1N1 strain) has recently garnered significant attention as an important cause of acute respiratory distress syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Community-acquired pneumonia represents the most common cause of ALI in humans (25). Most recently, influenza A (specifically the H1N1 strain) has received significant attention as a causative agent.…”

Section: Fas Drives Contraction Of the Recruited Macrophage Pool Durimentioning

confidence: 99%

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

Janssen

Barthel

Muldrow

et al. 2011

Am J Respir Crit Care Med

294

296

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Rationale: During acute lung injury (ALI) the macrophage pool expands markedly as inflammatory monocytes migrate from the circulation to the airspaces. As inflammation resolves, macrophage numbers return to preinjury levels and normal tissue structure and function are restored. Objectives: To determine the fate of resident and recruited macrophages during the resolution of ALI in mice and to elucidate the mechanisms responsible for macrophage removal. Methods: ALI was induced in mice using influenza A (H1N1; PR8) infection and LPS instillation. Dye labeling techniques, bone marrow transplantation, and surface immunophenotyping were used to distinguish resident and recruited macrophages during inflammation and to study the role of Fas in determining macrophage fate during resolving ALI. Measurements and Main Results: During acute and resolving lung injury from influenza A and LPS, a high proportion of the original resident alveolar macrophages persisted. In contrast, recruited macrophages exhibited robust accumulation in early inflammation, followed by a progressive decline in their number. This decline was mediated by apoptosis with local phagocytic clearance. Recruited macrophages expressed high levels of the death receptor Fas and were rapidly depleted from the airspaces by Fas-activating antibodies. In contrast, macrophage depletion was inhibited in mice treated with Fas-blocking antibodies and in chimeras with Fasdeficient bone marrow. Caspase-8 inhibition prevented macrophage apoptosis and delayed the resolution of ALI. Conclusions: These findings indicate that Fas-induced apoptosis of recruited macrophages is essential for complete resolution of ALI.

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