Introduction: Stroke is a major cause of death in sub-Saharan Africa, and approximately 80% of all deaths by stroke occur in the region. Evidence indicates that a greater number of years of potential life lost is due to Stroke, also the huge social and economic problem of stroke is large and demands efficient strategies for prevention.Aim: This descriptive systematic literature review explores the primary prevention strategy of stroke in Sub-Saharan Africa. This report draws on a comprehensive review of the literature.Methodology. The primary preventive strategies for stroke were systematically searched in Pub Med and Cinahl, Google, Google Scholar, Science Direct, Scopus, etc.Results: This review summarizes all aspects of the primary preventive strategies under the headings; the awareness of stroke, screening, identifiable risk factors, primary preventive strategies of stroke, and lastly the challenges of primary preventive strategies of stroke in sub-Saharan Africa.Conclusion; Primary preventive strategies in Sub-Saharan Africa (PPSS) include high-risk strategy and mass strategies. This included identifying risk factors for cerebrovascular diseases and controlling them. It also involved mass awareness of primary prevention strategies of stroke (PPSS) with the mass population campaign and digitalized strategies of prevention.